Muscle and skin sympathetic activities in Ross syndrome

Donadio, Vincenzo; Cortelli, Pietro; Giannoccaro, Maria Pia; Nolano, Maria; Stasi, Vitantonio Di; Baruzzi, Agostino; Liguori, Rocco

doi:10.1016/j.clinph.2011.11.263

Cited by 14 publications

(9 citation statements)

References 20 publications

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“…Microneurography displayed absent SSNA, SSR, and SVR, whereas MSNA was recorded showing normal characteristics in all patients. This study confirmed the selective involvement of skin sympathetic activity in RS and that microneurography is a useful functional tool in RS diagnosis (Donadio et al, 2012b).…”

Section: Ross Syndromesupporting

confidence: 79%

“…The underlying lesion affects postganglionic skin sympathetic nerve fibers, whereas the postganglionic muscle sympathetic branch is thought to be spared. A recent microneurographic study was conducted in eight patients with a typical clinical picture of RS confirmed by skin biopsy disclosing the pathological hallmark of this disorder (Donadio et al, 2012b). Microneurography displayed absent SSNA, SSR, and SVR, whereas MSNA was recorded showing normal characteristics in all patients.…”

Section: Ross Syndromementioning

confidence: 99%

See 1 more Smart Citation

Microneurographic recording from unmyelinated nerve fibers in neurological disorders: An update

Donadio

Liguori

2015

Clinical Neurophysiology

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Section: Ross Syndromesupporting

confidence: 79%

Section: Ross Syndromementioning

confidence: 99%

Microneurographic recording from unmyelinated nerve fibers in neurological disorders: An update

Donadio

Liguori

2015

Clinical Neurophysiology

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“…Other such aspects are related to the firing characteristics of the efferent nerve fibres (which can be studied by microneurography 5,6 ) but the link between the neurochemical codes of efferent C fiber populations and their firing patterns is unknown making the interpretation of frequently used autonomic tests difficult 7,8 . A better knowledge of these factors and relationships may also lead to a better understanding of the selective damage of autonomic fibers in human diseases, such as Parkinson´s disease 9–11 or Ross syndrome 12,13 .…”

Section: Introductionmentioning

confidence: 99%

The autonomic innervation of hairy skin in humans: an in vivo confocal study

Donadio

Incensi

Vacchiano

et al. 2019

Sci Rep

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The autonomic innervation of the skin includes different subsets of adrenergic and cholinergic fibers both in humans and animals. The corresponding chemical code is complex and often difficult to ascertain. Accordingly, a detailed histochemical description of skin autonomic fiber subtypes is lacking in humans. To characterize skin autonomic nerve subtypes may help to better understand the selective damage of specific skin autonomic fibers affecting human diseases such as the adrenergic fibers directed to skin vessels in Parkinson’s disease or the cholinergic sudomotor fibers in Ross Syndrome. The present study aimed at characterizing subtypes of autonomic fibers in relation to their target organs by means of an immunofluorescent technique and confocal microscopy. We studied 8 healthy subjects (5 males and 3 females) aged 45 ± 2 (mean ± SE) years without predisposing causes for peripheral neuropathy or autonomic disorders. They underwent skin biopsy from proximal (thigh) and distal (leg) hairy skin. A combination of adrenergic (i.e. tyrosine-hydroxylase- TH and dopamine beta-hydroxylase- DbH) and cholinergic (vesicular acetylcholine transporter- VACHT) autonomic markers and neuropeptidergic (i.e. neuropeptide Y- NPY, calcitonin gene-related peptide- CGRP, substance P- SP, and vasoactive intestinal peptide- VIP) markers were used to characterize skin autonomic fibers. The analysed skin autonomic structures included: 58 sweat glands, 91 skin arterioles and 47 arrector pili muscles. Our results showed that all skin structures presented a sympathetic adrenergic but also cholinergic innervation although in different proportions. Sympathetic adrenergic fibers were particularly abundant around arterioles and arrector pili muscles whereas sympathetic cholinergic fibers were mainly found around sweat glands. Neuropeptides were differently expressed in sympathetic fibers: NPY were found in sympathetic adrenergic fibers around skin arterioles and very seldom sweat glands but not in adrenergic fibers of arrector pili muscles. By contrast CGRP, SP and VIP were expressed in sympathetic cholinergic fibers. Cholinergic fibers expressing CGRP, SP or VIP without TH or DbH staining were found in arterioles and arrector pili muscles and they likely represent parasympathetic fibers. In addition, all skin structures contained a small subset of neuropeptidergic fibers devoid of adrenergic and cholinergic markers with a likely sensory function. No major differences were found between males and females and proximal and distal sites. In summary hairy skin contains sympathetic adrenergic and cholinergic fibers differently distributed around skin structures with a specific distribution of neuropeptides. The autonomic skin innervation also contains a small amount of fibers, likely to be parasympathetic and sensory.

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“…Mean age of presentation for women was 31 years (22-42) and for men was 27 years . The mean duration of time delay from the onset of symptoms to diagnosis of the disease was 6 years (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). In all patients, this clinical entity was suspected and diagnosed in a tertiary care center.…”

Section: Resultsmentioning

confidence: 99%

“…This is evident because only around 60 cases of Ross syndrome have been reported to date (including a previous case series of 12 and 7 subjects) despite being described by Ross as early as 1958. 1,7 With the existing knowledge of this disease, symptom control has been the only form of treatment that can be offered to patients with Ross syndrome. Modification of the work environment is the first step in management.…”

Section: Discussionmentioning

confidence: 99%