Muscle-brain communication in pain: The key role of myokines

Wang, Yuanyuan; Wu, Zifeng; Wang, Di; Huang, Ching-Hui; Xu, Jiali; Liu, Cunming; Yang, Chun

doi:10.1016/j.brainresbull.2021.11.017

Cited by 8 publications

(4 citation statements)

References 204 publications

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“…Furthermore, treadmill running in NPP model rats restored the expression of 5HT receptors in spinal cord dorsal horns [ 37 ]. In addition, the role of myokines secreted by skeletal muscle, including brain-derived neurotrophic factor (BNDF), irisin, cathepsin B, and insulin-like growth factor-I (IFG-I), in inducing EIH effects was extensively reviewed by Wang et al [ 38 ]. Thus, well-characterized analgesic mechanisms of EIH effects have been explained by the endogenous opioid system, serotonergic system, and myokine system.…”

Section: Brain Mechanisms Of Exercise-induced Hypoalgesia (Eih)mentioning

confidence: 99%

Brain Mechanisms of Exercise-Induced Hypoalgesia: To Find a Way Out from “Fear-Avoidance Belief”

Kami

Tajima

Senba

2022

IJMS

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It is well known that exercise produces analgesic effects (exercise-induced hypoalgesia (EIH)) in animal models and chronic pain patients, but the brain mechanisms underlying these EIH effects, especially concerning the emotional aspects of pain, are not yet fully understood. In this review, we describe drastic changes in the mesocorticolimbic system of the brain which permit the induction of EIH effects. The amygdala (Amyg) is a critical node for the regulation of emotions, such as fear and anxiety, which are closely associated with chronic pain. In our recent studies using neuropathic pain (NPP) model mice, we extensively examined the association between the Amyg and EIH effects. We found that voluntary exercise (VE) activated glutamate (Glu) neurons in the medial basal Amyg projecting to the nucleus accumbens (NAc) lateral shell, while it almost completely suppressed NPP-induced activation of GABA neurons in the central nucleus of the Amyg (CeA). Furthermore, VE significantly inhibited activation of pyramidal neurons in the ventral hippocampus-CA1 region, which play important roles in contextual fear conditioning and the retrieval of fear memory. This review describes novel information concerning the brain mechanisms underlying EIH effects as a result of overcoming the fear-avoidance belief of chronic pain.

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Section: Brain Mechanisms Of Exercise-induced Hypoalgesia (Eih)mentioning

confidence: 99%

Brain Mechanisms of Exercise-Induced Hypoalgesia: To Find a Way Out from “Fear-Avoidance Belief”

Kami

Tajima

Senba

2022

IJMS

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“…Epigenetic mechanisms are also driven in the spinal dorsal horn ( Kami et al, 2016b ). Moreover, it has been argued that myokines secreted from contracted muscles may play a role in EIH ( Wang et al, 2022 ) and enhanced wound healing of injured skin by treadmill running may contribute to EIH ( Kawanishi et al, 2022 ). In this review we focus on brain mechanisms, especially on the limbic system.…”

Section: Exercise Is a Universal Prescription For Chronic Pain Statesmentioning

confidence: 99%

Exercise therapy for chronic pain: How does exercise change the limbic brain function?

Senba,

Kami

2023

Neurobiology of Pain

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“…Myokines are molecules able to cross the BBB and directly stimulate the synthesis of BDNF at the hippocampal level ( 132 ). Accordingly, the group of Dr. Y Wang has recently evidenced that the muscle acts as a secretory organ, by producing myokines, having the critical role to communicate with other organs, such as the brain, and evocating the increase in the brain levels of BDNF ( 133 ). For example, the irisin is another myokine produced following physical exercise, which can increase the production of BDNF at the hippocampal level through the mediation of PGC-1α ( 134 ).…”

Section: Strategies For Improving the Pathophysiology Of Msmentioning

confidence: 99%

A Brief Overview on BDNF-Trk Pathway in the Nervous System: A Potential Biomarker or Possible Target in Treatment of Multiple Sclerosis?

et al. 2022

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The growing incidence of neurodegenerative disorders in our populations is leading the research to identify potential biomarkers and targets for facilitating their early management and treatments. Biomarkers represent the crucial indicators of both physiological and pathological processes. Specific changes in molecular and cellular mechanisms of physiological processes result in biochemical alterations at systemic level, which can give us comprehensive information regarding the nature of any disease. In addition, any disease biomarker should be specific and reliable, able to consent of distinguishing the physiological condition of a tissue, organ, or system from disease, and be diverse among the various diseases, or subgroups or phenotypes of them. Accordingly, biomarkers can predict chances for diseases, facilitate their early diagnosis, and set guidelines for the development of new therapies for treating diseases and disease-making process. Here, we focus our attention on brain neurotrophic factor (BDNF)–tropomyosin receptor kinase (Trk) pathway, describing its multiple roles in the maintenance of central nervous system (CNS) health, as well as its implication in the pathogenesis of multiple sclerosis (MS). In addition, we also evidence the features of such pathway, which make of it a potential MS biomarker and therapeutic target.

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Muscle-brain communication in pain: The key role of myokines

Cited by 8 publications

References 204 publications

Brain Mechanisms of Exercise-Induced Hypoalgesia: To Find a Way Out from “Fear-Avoidance Belief”

Brain Mechanisms of Exercise-Induced Hypoalgesia: To Find a Way Out from “Fear-Avoidance Belief”

Exercise therapy for chronic pain: How does exercise change the limbic brain function?

A Brief Overview on BDNF-Trk Pathway in the Nervous System: A Potential Biomarker or Possible Target in Treatment of Multiple Sclerosis?

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