Muscle cell communication in development and repair

Demonbreun, Alexis R.; McNally, Elizabeth M.

doi:10.1016/j.coph.2017.03.008

Cited by 52 publications

(44 citation statements)

References 83 publications

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“…All this may reflect the deregulation of physiological functions exerted by EV-mediated intercellular communication during organogenesis and tissue regeneration/repair [166][167][168]. In fact, EV-mediated interactions between inflammatory cells, endothelial cells, mesenchymal cells and tissue-specific stem cells are involved in the regeneration of injured tissues and organs, including skeletal muscle, cardiac muscle, gastrointestinal, neural, renal, and respiratory tissues [169][170][171][172][173].…”

Section: Evs In Tumorigenesismentioning

confidence: 99%

Extracellular Vesicles as Signaling Mediators and Disease Biomarkers across Biological Barriers

Simeone

Bologna

Lanuti

et al. 2020

IJMS

147

117

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Extracellular vesicles act as shuttle vectors or signal transducers that can deliver specific biological information and have progressively emerged as key regulators of organized communities of cells within multicellular organisms in health and disease. Here, we survey the evolutionary origin, general characteristics, and biological significance of extracellular vesicles as mediators of intercellular signaling, discuss the various subtypes of extracellular vesicles thus far described and the principal methodological approaches to their study, and review the role of extracellular vesicles in tumorigenesis, immunity, non-synaptic neural communication, vascular-neural communication through the blood-brain barrier, renal pathophysiology, and embryo-fetal/maternal communication through the placenta.

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Section: Evs In Tumorigenesismentioning

confidence: 99%

Extracellular Vesicles as Signaling Mediators and Disease Biomarkers across Biological Barriers

Simeone

Bologna

Lanuti

et al. 2020

IJMS

147

117

View full text Add to dashboard Cite

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“…These high GH concentrations lead to anti-insulin effects in both liver and adipose tissues, which increase insulin resistance ( 72 ). IGF-1 plays an important role in exercise training and increasing IGF-1 levels mediate a lowering of the GH concentration in terms of skeletal muscle growth and repair ( 73 ). It mediates protein kinase B activation and concomitantly promotes protein synthesis and inhibits protein degradation ( 74 ).…”

Section: Mechanisms By Which Exercise Improves Nafld; a Narrative Revmentioning

confidence: 99%

Therapeutic Approaches to Nonalcoholic Fatty Liver Disease: Exercise Intervention and Related Mechanisms

et al. 2018

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Exercise training ameliorates nonalcoholic fatty liver disease (NAFLD) as well as obesity and metabolic syndrome. Although it is difficult to eliminate the effects of body weight reduction and increased energy expenditure—some pleiotropic effects of exercise training—a number of studies involving either aerobic exercise training or resistance training programs showed ameliorations in NAFLD that are independent of the improvements in obesity and insulin resistance. In vivo studies have identified effects of exercise training on the liver, which may help to explain the “direct” or “independent” effect of exercise training on NAFLD. Exercise training increases peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) expression, improves mitochondrial function and leads to reduced hepatic steatosis, inflammation, fibrosis, and tumor genesis. Crosstalk between the liver and adipose tissue, skeletal muscle and the microbiome is also a possible mechanism for the effect of exercise training on NAFLD. Although numerous studies have reported benefits of exercise training on NAFLD, the optimal duration and intensity of exercise for the prevention or treatment of NAFLD have not been established. Maintaining adherence of patients with NAFLD to exercise training regimes is another issue to be resolved. The use of comprehensive analytical approaches to identify biomarkers such as hepatokines that specifically reflect the effect of exercise training on liver functions might help to monitor the effect of exercise on NAFLD, and thereby improve adherence of these patients to exercise training. Exercise training is a robust approach for alleviating the pathogenesis of NAFLD, although further clinical and experimental studies are required.

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“…Autocrine and paracrine muscle-growth inhibition has previously been attributed to myostatin, which is a TGFβ family member that is most dominantly expressed in skeletal muscle [ 102 ]. TGFβ1 and myostatin are released by muscle cells to provide signaling cues for muscle regeneration [ 103 ]. In an animal model of chronic muscle disease, myostatin inhibition increased muscle growth and reduced fibrosis, indicating direct promotion of fibroblast proliferation resulting in muscle fibrosis in vivo [ 104 ].…”

Section: Commonalities and Differences In Healing Cascades Of Diffmentioning

confidence: 99%

Immunology Guides Skeletal Muscle Regeneration

Sass

Fuchs

Pumberger

et al. 2018

IJMS

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Soft tissue trauma of skeletal muscle is one of the most common side effects in surgery. Muscle injuries are not only caused by accident-related injuries but can also be of an iatrogenic nature as they occur during surgical interventions when the anatomical region of interest is exposed. If the extent of trauma surpasses the intrinsic regenerative capacities, signs of fatty degeneration and formation of fibrotic scar tissue can occur, and, consequentially, muscle function deteriorates or is diminished. Despite research efforts to investigate the physiological healing cascade following trauma, our understanding of the early onset of healing and how it potentially determines success or failure is still only fragmentary. This review focuses on the initial physiological pathways following skeletal muscle trauma in comparison to bone and tendon trauma and what conclusions can be drawn from new scientific insights for the development of novel therapeutic strategies. Strategies to support regeneration of muscle tissue after injury are scarce, even though muscle trauma has a high incidence. Based on tissue specific differences, possible clinical treatment options such as local immune-modulatory and cell therapeutic approaches are suggested that aim to support the endogenous regenerative potential of injured muscle tissues.

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Muscle cell communication in development and repair

Cited by 52 publications

References 83 publications

Extracellular Vesicles as Signaling Mediators and Disease Biomarkers across Biological Barriers

Extracellular Vesicles as Signaling Mediators and Disease Biomarkers across Biological Barriers

Therapeutic Approaches to Nonalcoholic Fatty Liver Disease: Exercise Intervention and Related Mechanisms

Immunology Guides Skeletal Muscle Regeneration

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