Muscle composition measured by CT scan is a measurable predictor of overall survival in advanced ovarian cancer

Low Skeletal Muscle Density Is Associated with Early Death in Patients with Perihilar Cholangiocarcinoma Regardless of Subsequent Treatment

“…Previous studies as well as the current study show that sarcopenia is heavily correlated with cancer stage and treatment; yet across all strata of treatment and cancer stage, patients with sarcopenia perform worse [41, 42]. This indicates that, regardless of cancer stage and treatment, sarcopenia is an independent predictor of outcome.…”

Activity Behaviors and Physiological Characteristics of Women With Advanced-Stage Ovarian Cancer: A Preliminary Cross-sectional Investigation

“…This finding implies that any PA is better than none but highlights the additional advantages of higher-intensity, prolonged PA bouts. The moderate correlation between MVPA and muscle morphology requires further investigation but is notable in light of research suggesting an association between low muscle mass 42 and density 40,43 at diagnosis and mortality in OC survivors. All sedentary outcome measures were negatively correlated with volumetric bone mineral density, confirming the importance of minimizing sedentary behavior to maintain good bone health in OC survivors.…”

A Physiological Profile of Ovarian Cancer Survivors to Inform Tailored Exercise Interventions and the Development of Exercise Oncology Guidelines

“…However, current data do not confirm an association between low muscle mass at diagnosis and OC survival. 46,59,61 An important finding by Rutten et al 59 is the association of skeletal muscle loss during neoadjuvant chemotherapy with decreased survival, although this finding requires further confirmation.…”

“…Low muscle mass, indicated by a skeletal muscle index of less than 39.0 cm 2 /m 2 , was observed in 45% of a large cohort of women with newly diagnosed advanced-stage OC. 61 The skeletal muscle index was calculated by dividing skeletal muscle area (in centimeters squared), measured preoperatively with computed tomography at the level of the third lumbar vertebra, by the height squared (in meters squared). However, current data do not confirm an association between low muscle mass at diagnosis and OC survival.…”

“…62 Low skeletal muscle attenuation at diagnosis was associated with decreased overall survival in 2 separate OC studies. 46,61 The findings of these retrospective studies require validation in future randomized controlled trials.…”