Muscle-derived decellularised extracellular matrix improves functional recovery in a rat latissimus dorsi muscle defect model

Chen, Xiaoyu K.; Walters, James

doi:10.1016/j.bjps.2013.07.037

Cited by 60 publications

(54 citation statements)

References 26 publications

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“…In support, numerous studies have reported improvements in muscle strength after the transplantation of a decellularized ECM to the VML defect area, which promoted deposition of collagen within the VML defect [Chen and Walters, 2013;Corona et al, 2013bGarg et al, 2014c]. In effect, a presumptive functional bridge was created in which forces generated by the remaining musculature were more efficiently transmitted to its tendon.…”

Section: Exacerbated Prolonged Strength Deficits Are Multifactorialmentioning

confidence: 81%

Pathophysiology of Volumetric Muscle Loss Injury

Corona

Wenke

Ward

2016

Cells Tissues Organs

134

108

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Volumetric muscle loss (VML) injuries are prevalent in civilian and military trauma patients and are known to impart chronic functional deficits. The frank loss of muscle tissue that defines VML injuries is beyond the robust reparative and regenerative capacities of mammalian skeletal muscle. Given the nature of VML injuries, there is a clear need to develop therapies that promote de novo regeneration of skeletal muscle fibers, which can integrate with the remaining musculature and restore muscle strength. However, the pathophysiology of VML injuries is not completely defined, and, therefore, there may be other opportunities to improve functional outcomes other than de novo regeneration. Herein, clinical and preclinical studies of VML were reviewed to ascertain salient manifestations of VML injury that can impair limb function and muscle strength. The limited clinical data available highlighted proliferative fibrosis secondary to VML injury as a viable target to improve limb range of motion. Selected preclinical studies that used standardized neuromuscular functional assessments broadly identified that the muscle mass remaining after VML injury is performing suboptimally, and, therefore, percent VML strength deficits are significantly worse than can be explained by the initial frank loss of contractile machinery. Potential mechanisms of suboptimal strength of the remaining muscle mass suggested within the literature include intramuscular nerve damage, muscle architectural perturbations, and diminished transmission of force. Collectively, both clinical and preclinical data indicate a complex pathophysiology after VML that presents multiple therapeutic targets. This is a work of the US Government and is not subject to copyright protection in the USA. Foreign copyrights may apply. Published by S. Karger AG, Basel

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Section: Exacerbated Prolonged Strength Deficits Are Multifactorialmentioning

confidence: 81%

Pathophysiology of Volumetric Muscle Loss Injury

Corona

Wenke

Ward

2016

Cells Tissues Organs

134

108

View full text Add to dashboard Cite

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“…This defect model is produced by making two 8 × 12 mm holes in the lateral part of the distal LD muscle and was found to create a functional deficit of about 30% force reduction during in situ muscle testing ( fig. 2 a) [Chen and Walters, 2013].…”

Section: Abdominal Wallmentioning

confidence: 99%

“…The distal tendon is then connected to a force transducer or servomotor, stimulated using electrodes (either connected to the nerve or across the muscle), and force, typically peak isometric tetanic force, is recorded. This type of in situ muscle testing has been used on the abdominal wall [Valentin et al, 2010], gastrocnemius [Merritt et al, 2010a, b], LD [Chen and Walters, 2013], and TA VML models [Wu et al, 2012;VanDusen et al, 2014a].…”

Section: Functional Measures Of Muscle Strengthmentioning

confidence: 99%

“…The rodent LD models were developed due to similarities with the muscle structures of the craniofacial region [Machingal et al, 2011;Corona et al, 2012;Chen and Walters, 2013]. The murine model involves resection of 20-30 mg muscle tissue from the medial half of the LD constituting about 50% of the total LD mass [Machingal et al, 2011;Corona et al, 2012].…”

Section: Abdominal Wallmentioning

confidence: 99%

“…Presumably, the VML injury involves mostly an irreversible fiber injury. Because of the frank tissue loss, recovery in the VML model is very likely dependent on the restoration of ECM structures Chen and Walters, 2013;Corona et al, 2014].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Guidelines for Models of Skeletal Muscle Injury and Therapeutic Assessment

Willett

Krishnan²,

et al. 2016

Cells Tissues Organs

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Volumetric muscle loss (VML) injuries present a large clinical challenge with a significant need for new interventions. While there have been numerous reviews on muscle injury models, few have critically evaluated VML models. The objective of this review is to discuss current preclinical models of VML in terms of models, analytical outcomes, and therapeutic interventions, and to provide guidelines for the future use of preclinical VML models. This is a work of the US Government and is not subject to copyright protection in the USA. Foreign copyrights may apply. Published by S. Karger AG, Basel

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Vascularized and Innervated Skeletal Muscle Tissue Engineering

Gilbert-Honick

Grayson

2019

Adv Healthcare Materials

133

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Volumetric muscle loss (VML) is a devastating loss of muscle tissue that overwhelms the native regenerative properties of skeletal muscle and results in lifelong functional deficits. There are currently no treatments for VML that fully recover the lost muscle tissue and function. Tissue engineering presents a promising solution for VML treatment and significant research has been performed using tissue engineered muscle constructs in preclinical models of VML with a broad range of defect locations and sizes, tissue engineered construct characteristics, and outcome measures. Due to the complex vascular and neural anatomy within skeletal muscle, regeneration of functional vasculature and nerves is vital for muscle recovery following VML injuries. This review aims to summarize the current state of the field of skeletal muscle tissue engineering using 3D constructs for VML treatment with a focus on studies that have promoted vascular and neural regeneration within the muscle tissue post-VML.

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Muscle-derived decellularised extracellular matrix improves functional recovery in a rat latissimus dorsi muscle defect model

Cited by 60 publications

References 26 publications

Pathophysiology of Volumetric Muscle Loss Injury

Pathophysiology of Volumetric Muscle Loss Injury

Guidelines for Models of Skeletal Muscle Injury and Therapeutic Assessment

Vascularized and Innervated Skeletal Muscle Tissue Engineering

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