Muscle Fiber Composition and Capillary Density in Women and Men With NIDDM

Mårin, Per; Andersson, Björn; Krotkiewski, M; Björntorp, Per

doi:10.2337/diacare.17.5.382

Cited by 300 publications

(275 citation statements)

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“…Using QRT-PCR and Western blot techniques, we were able to detect a decrease in type 1 MHC mRNA and protein expression levels in PLN muscles of swine on DMetS diet. Previous studies in humans showed that obese individuals with or without NIDDM had a significantly lower percentage of type 1 and higher percentage of type 2b/x muscle fibers than lean individuals (10,17,24,25,29,35). Overall, the trends we noted in changes of fiber type composition in muscles of Ossabaw swine on MetS and DMetS diets are highly consistent with findings in obese and NIDDM humans.…”

Section: E853supporting

confidence: 89%

“…Lillioja et al (22) showed that in vivo insulin action determined by the euglycemic clamp was positively correlated with the percentage of type 1 fibers and negatively correlated with the percentage of type 2b/x fibers in vastus lateralis muscles of humans. Several studies showed that obese individuals with or without type 2 diabetes had a significantly lower percentage of type 1 and a higher percentage of type 2b/x muscle fibers than lean individuals (2,10,17,24,25,29,35).…”

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confidence: 99%

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Effect of diet-induced obesity and metabolic syndrome on skeletal muscles of Ossabaw miniature swine

Clark

Alloosh

Wenzel

et al. 2011

American Journal of Physiology-Endocrinology and Metabolism

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TY. Effect of diet-induced obesity and metabolic syndrome on skeletal muscles of Ossabaw miniature swine. Am J Physiol Endocrinol Metab 300: E848 -E857, 2011. First published February 8, 2011 doi:10.1152/ajpendo.00534.2010.-Ossabaw swine fed excess kilocalorie diet develop metabolic syndrome (MS) characterized by obesity, hypertension, insulin resistance, and glucose intolerance with/ without dyslipidemia. The purpose of this study was to test the hypothesis that MS would have a detrimental effect on skeletal muscle structure and cause changes in the expression of myosin heavy chains (MHCs). Adult male Ossabaw swine were fed for 24 wk highfructose or high-fat/cholesterol/fructose diets to induce normolipidemic MS (MetS) or dyslipidemic MS (DMetS), respectively, and were compared with the lean swine on control diet. MetS swine showed mild MS, lacking increases in total and low density lipoprotein (LDL) cholesterol, both of which were highly upregulated in DMetS swine. There was an ϳ1.2-fold increase in the cross-sectional areas of muscle fibers in MetS and DMetS groups compared with control for biceps femoris and plantaris muscles. In plantaris muscles, DMetS diet caused an ϳ2-fold decrease in slow MHC mRNA and protein expression and an ϳ1.2-to 1.8-fold increase in the number of intramyocellular lipid (IMCL) droplets without large changes in the size of the droplets. There was a trend to the decrease in slow MHC expression in muscles of swine on MetS diet. The number of IMCL droplets in muscle fibers of the MetS group was comparable to controls. These data correlate well with the data on total plasma cholesterol (control ϭ 60, MetS ϭ 70, and DMetS ϭ 298 mg/dl) and LDL (control ϭ 29, MetS ϭ 30, and DMetS ϭ 232 mg/dl). We conclude that structural changes observed in skeletal muscle of obese Ossabaw swine correlate with those previously reported for obese humans. obesity; fiber type composition; intramyocellular lipids; myosin heavy chains SKELETAL MUSCLE CONSTITUTES more than 40% of the total body weight and is one of the most important organs for glucose homeostasis. The mass and composition of skeletal muscle are critical for its functions. Obesity is a major risk factor for the development of both insulin resistance and noninsulin-dependent diabetes mellitus (NIDDM). Obesityrelated abnormalities lead to excessive accumulation of triglycerides and fatty acids in skeletal muscle fibers in the form of intramyocellular lipids (IMCL). IMCL accumulation is strongly associated with the impairment of glucose metabolism, oxidative stress, deficiency in energy production, insulin resistance, and eventually the development of type 2 diabetes (reviewed in Refs. 3 and 26).The fiber type composition of skeletal muscle has strong effects on metabolism and utilization of glucose and lipids. Lillioja et al. (22) showed that in vivo insulin action determined by the euglycemic clamp was positively correlated with the percentage of type 1 fibers and negatively correlated with the percentage of type 2b/x fibers in vastus lateralis ...

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Section: E853supporting

confidence: 89%

mentioning

confidence: 99%

Effect of diet-induced obesity and metabolic syndrome on skeletal muscles of Ossabaw miniature swine

Clark

Alloosh

Wenzel

et al. 2011

American Journal of Physiology-Endocrinology and Metabolism

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“…Thus, it is tempting to speculate that the KE muscles of our patients could have been 5 characterized by a higher proportion of type II fibers with respect to the arm muscles 6 in reason of a greater diabetes-induced impairment as suggested by some (Gaster et 7 al., 2001;Hickey et al, 1995;Mårin et al, 1994;Mogensen et al, 2007;Oberbach et 8 al., 2006;Segerström et al, 2011;Stuart et al, 2013) but not all (Andreassen et al, 9 2014;Cederholm et al, 2000;He et al, 2001;Leenders et al, 2013;Zierath et al, 10 1996) studies. This would be reflected by lower TTF due to the greater fatigability of 11 glycolytic fibers, by the higher MFCV slopes during the fatiguing contractions, as 12 well as by the greater training effect on the torque-velocity relationship.…”

Section: Muscle Fatigue 10mentioning

confidence: 99%

Effect of exercise training on neuromuscular function of elbow flexors and knee extensors of type 2 diabetic patients

Bazzucchi

Vito

Felici

et al. 2015

Journal of Electromyography and Kinesiology

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Massimo (2015) Effect of exercise training on neuromuscular function of elbow flexors and knee extensors of type 2 diabetic patients. Journal of Electromyography and Kinesiology, 25 (5). pp. 815-823.Downloaded from: http://insight.cumbria.ac.uk/2048/ Usage of any items from the University of Cumbria's institutional repository 'Insight' must conform to the following fair usage guidelines.Any item and its associated metadata held in the University of Cumbria's institutional repository Insight (unless stated otherwise on the metadata record) may be copied, displayed or performed, and stored in line with the JISC fair dealing guidelines (available here) for educational and not-for-profit activities provided that• the authors, title and full bibliographic details of the item are cited clearly when any part of the work is referred to verbally or in the written form• a hyperlink/URL to the original Insight record of that item is included in any citations of the work • the content is not changed in any way• all files required for usage of the item are kept together with the main item file. You may not• sell any part of an item• refer to any part of an item without citation • amend any item or contextualise it in a way that will impugn the creator's reputation• remove or alter the copyright statement on an item.The full policy can be found here. Alternatively contact the University of Cumbria Repository Editor by emailing insight@cumbria.ac.uk. Accepted Manuscript

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“…Type 2 diabetes is also associated with an increased proportion of fast, glycolytic type 2 fibers (Marin, et al, 1994, Oberbach, et al, 2006. The transition from fast to slow fiber is more difficult to achieve in humans than the other way round.…”

Section: Strategies To Improve the Human Myotube Modelmentioning

confidence: 99%

Are cultured human myotubes far from home?

et al. 2013

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IntroductionSatellite cells can be isolated from skeletal muscle biopsies, activated to proliferating myoblast and differentiated into multinuclear myotubes in culture. These cell cultures represent an essential model system to intact human skeletal muscle, which can be modulated ex vivo. Advantages of this system include; having the most relevant genetic background to study human disease (as opposed to rodent cell cultures), the extracellular environment can be precisely controlled and the cells are not immortalized, thereby offering the possibility of studying innate characteristics of the donor. This review will focus on how human myotubes can be used as a tool to study metabolism in skeletal muscles, with a special attention to changes in muscle energy metabolism in obesity and type 2 diabetes.Limitations of this cell system and possible approaches to improve the current model will also be discussed.

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Muscle Fiber Composition and Capillary Density in Women and Men With NIDDM

Cited by 300 publications

References 0 publications

Effect of diet-induced obesity and metabolic syndrome on skeletal muscles of Ossabaw miniature swine

Effect of diet-induced obesity and metabolic syndrome on skeletal muscles of Ossabaw miniature swine

Effect of exercise training on neuromuscular function of elbow flexors and knee extensors of type 2 diabetic patients

Are cultured human myotubes far from home?

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