Muscle lineage switching by migratory behaviour-driven epigenetic modifications of human mesenchymal stem cells on a dendrimer-immobilized surface

Ayuningtyas, Fitria Dwi; Kim, Mee‐Hae; Kino‐oka, Masahiro

doi:10.1016/j.actbio.2020.02.026

Cited by 9 publications

(12 citation statements)

References 41 publications

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“…Cells perceive and transmit mechanical signals from the extracellular matrix to the cytoskeleton and nuclear lamina, which is considered a key mechanical sensor that can directly affect chromatin structure, gene expression, and epigenetic modification. Experiments have shown that through extracellular carriers, such as photosensitive hydrogels [ 112 ] and dendrimer-immobilized surface [ 113 ], mechanical signals can be transmitted to BMSCs. The enhanced hardness of the extracellular matrix leads to bone formation of BMSCs.…”

Section: Epigenetic Therapy For Bmsc Dysfunction In Age-related Bone ...mentioning

confidence: 99%

Epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseases

Zhao

Qiu

et al. 2022

Stem Cell Res Ther

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As global aging accelerates, the prevention and treatment of age-related bone diseases are becoming a critical issue. In the process of senescence, bone marrow mesenchymal stem cells (BMSCs) gradually lose the capability of self-renewal and functional differentiation, resulting in impairment of bone tissue regeneration and disorder of bone tissue homeostasis. Alteration in epigenetic modification is an essential factor of BMSC dysfunction during aging. Its transferability and reversibility provide the possibility to combat BMSC aging by reversing age-related modifications. Emerging evidence demonstrates that epigenetic therapy based on aberrant epigenetic modifications could alleviate the senescence and dysfunction of stem cells. This review summarizes potential therapeutic targets for BMSC aging, introduces some potential approaches to alleviating BMSC aging, and analyzes its prospect in the clinical application of age-related bone diseases.

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Section: Epigenetic Therapy For Bmsc Dysfunction In Age-related Bone ...mentioning

confidence: 99%

Epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseases

Zhao

Qiu

et al. 2022

Stem Cell Res Ther

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“…To date, a number of studies have investigated the effect of polyamidoamine (PAMAM) dendrimer generation number on cell fate within the mesenchymal lineage. 57,58 Ayuningtyas et al 59 explored the mechanism governing muscle lineage switching of hMSCs through migration and cellular and nuclear deformation on dendrimer surfaces. Cells cultured on G3 and G5 surfaces exhibited more dynamic temporal stretching and contraction, which is representative of active migration, compared with cells grown on a G1 surface.…”

Section: Biomaterials Sciencementioning

confidence: 99%

“…Importantly, this material-induced spectrum of histone modification resulted in diverse differentiation patterns; differentiation for G1, G3, and G5 cells tended towards smooth muscle, skeletal muscle and cardiac muscle lineages, respectively. 59…”

Section: Bionanomaterials and Epigenetics In Stem Cellsmentioning

confidence: 99%

Current progress in bionanomaterials to modulate the epigenome

2022

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“…Besides, bioprinting offers the opportunity for tailored periodontal defect coverage in case of trauma or surgery. By considering all of these properties, such materials are sometimes designated to be "cell-instructive", meaning that they harbor all necessary biochemical and biophysical information to properly integrate cells into the site of defect [298,299].…”

Section: May the Force Be With You: Mt And Its Implications For Periodontal Regenerationmentioning

confidence: 99%

From the Matrix to the Nucleus and Back: Mechanobiology in the Light of Health, Pathologies, and Regeneration of Oral Periodontal Tissues

et al. 2021

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Among oral tissues, the periodontium is permanently subjected to mechanical forces resulting from chewing, mastication, or orthodontic appliances. Molecularly, these movements induce a series of subsequent signaling processes, which are embedded in the biological concept of cellular mechanotransduction (MT). Cell and tissue structures, ranging from the extracellular matrix (ECM) to the plasma membrane, the cytosol and the nucleus, are involved in MT. Dysregulation of the diverse, fine-tuned interaction of molecular players responsible for transmitting biophysical environmental information into the cell’s inner milieu can lead to and promote serious diseases, such as periodontitis or oral squamous cell carcinoma (OSCC). Therefore, periodontal integrity and regeneration is highly dependent on the proper integration and regulation of mechanobiological signals in the context of cell behavior. Recent experimental findings have increased the understanding of classical cellular mechanosensing mechanisms by both integrating exogenic factors such as bacterial gingipain proteases and newly discovered cell-inherent functions of mechanoresponsive co-transcriptional regulators such as the Yes-associated protein 1 (YAP1) or the nuclear cytoskeleton. Regarding periodontal MT research, this review offers insights into the current trends and open aspects. Concerning oral regenerative medicine or weakening of periodontal tissue diseases, perspectives on future applications of mechanobiological principles are discussed.

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Muscle lineage switching by migratory behaviour-driven epigenetic modifications of human mesenchymal stem cells on a dendrimer-immobilized surface

Cited by 9 publications

References 41 publications

Epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseases

Epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseases

Current progress in bionanomaterials to modulate the epigenome

From the Matrix to the Nucleus and Back: Mechanobiology in the Light of Health, Pathologies, and Regeneration of Oral Periodontal Tissues

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