Muscle LPL Activity, Plasma and Muscle Triglycerides in Trained Thyroidectomized Rats

Kaciuba-Uściłko, H.; Ga, Dudley; Terjung, RL

doi:10.1055/s-2007-1019377

“…Data are mean ± SD ES Effect size (difference between means divided by the SD of the untrained group); MUFA monounsaturated fatty acids; PUFA polyunsaturated fatty acids; ND not detected; U/S unsaturated/ saturated; UI unsaturation index *Significantly different from untrained (P<0.05) a Indices of enzyme activity were calculated from the sum of the concentration of each fatty acid in PL and TG Concerning muscle, its total TG content was greatly reduced with training. Most of the relevant studies have found decreases (Froberg et al 1972;Kaciuba-Uscilko et al 1981;Oscai et al 1982), although no differences between trained and untrained rats have also been reported (Lee et al 2002). The reduction found in the present study (by 75%) was larger than the ones found in the soleus (32%) and EDL (34%) of the same animals , suggesting a greater responsiveness of gastrocnemius muscle TG to training.…”

Section: Discussioncontrasting

confidence: 75%

Effect of exercise training on the fatty acid composition of lipid classes in rat liver, skeletal muscle, and adipose tissue

Petridou

¹

,

Nikolaidis

²

,

Matsakas

³

et al. 2005

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The aim of the present study was to examine the effects of 8 weeks of exercise training on the fatty acid composition of phospholipids (PL) and triacylglycerols (TG) in rat liver, skeletal muscle (gastrocnemius medialis), and adipose tissue (epididymal and subcutaneous fat). For this purpose, the relevant tissues of 11 trained rats were compared to those of 14 untrained ones. Training caused several significant differences of large effect size in the concentrations and percentages of individual fatty acids in the aforementioned lipid classes. The fatty acid composition of liver PL, in terms of both concentrations and percentages, changed with training. The TG content of muscle and subcutaneous adipose tissue decreased significantly with training. In contrast to the liver, where no significant differences in the fatty acid profile of TG were found, muscle underwent more significant differences in TG than PL, and adipose tissue only in TG. Most differences were in the same direction in muscle and adipose tissue TG, suggesting a common underlying mechanism. Estimated fatty acid elongase activity was significantly higher, whereas Delta(9)-desaturase activity was significantly lower in muscle and adipose tissue of the trained rats. In conclusion, exercise training modified the fatty acid composition of liver PL, muscle PL and TG, as well as adipose tissue TG. These findings may aid in delineating the effects of exercise on biological functions such as membrane properties, cell signaling, and gene expression.

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“…In contrast, Hurley and co-workers (132) failed to observe a significant change in the triacylglycerol content of the vastus lateralis muscle in male subjects after a strenuous training program for 12 weeks, confirming earlier findings (85). Moreover, in rats the content of triacylglycerols was found to be decreased in fasttwitch red, slow-twitch red, and fast-twitch white fibers after endurance training (143,200). At present, no satisfactory explanation for the deviating findings can be offered (98).…”

Section: Utilization Of Intramuscular Triacylg/ycerols In Endurance-tmentioning

confidence: 38%

“…In the same muscle, hyperthyroidism causes a decrease in LPL activity. The observation that sequestration of radiolabeled fatty acids, derived from circulating triacylglycerols, in red muscle cells is increased in the hyperthyroid animals led the authors to conclude that an inverse relationship exists between LPL activity and circulating triacylglycerol utilization in cases of high levels of plasma thyroid hormones (143).…”

Section: Fatty Acids In Circulating Lipoproteinsmentioning

confidence: 98%

See 1 more Smart Citation

Lipid Metabolism in Muscle

Vusse

¹

,

Reneman

²

1996

Comprehensive Physiology

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The sections in this article are: Supply and Cellular Uptake of Upids in Skeletal Muscles Albumin‐Bound Fatty Acids Fatty Acids in Circulating Lipoproteins Skeletal Muscle Fatty Acid Uptake Fatty Acid Metabolism in the Skeletal Muscle Cell Activation and Oxidation of Fatty Acids Intramuscular Triacylglycerols Supply and Utilization of Upids During Exercise Albumin‐Bound Fatty Acids in Plasma during Exercise Circulating Lipoprotein‐Triacylglycerols as a Potential Source of Fatty Acids during Exercise Contribution of Intramuscular Triacylglycerols to Fatty Acid Oxidation during Exercise Relative Contribution of Various Sources of Lipids to Overall Fatty Acid Utilization during Exercise Gender Differences in Lipid Utilization during Exercise Effect of Training on Skeletal Muscle Lipid Utilization Advantages of Enhanced Lipid Utilization by Trained Muscles during Exercise Possible Causes of Increased Lipid Consumption by Trained Muscles during Exercise Utilization of Plasma‐Borne Fatty Acids by Trained Muscles Circulating Lipoproteins as an Additional Source of Lipids for Trained Muscles Utilization of Intramuscular Triacylglycerols in Endurance‐Trained Muscles Regulation of Fatty Acid Release from Intramuscular Triacylglycerols in Trained Muscles Effect of Diet on Muscle Lipid Metabolism High‐Carbohydrate vs. High‐Fat Diets in Relation to Physical Performance Shift from Carbohydrate to Lipid Utilization by High‐Fat Diet Source of Lipid for Muscles during High‐Fat Diet Feeding Possible Mechanisms Underlying Increased Muscular Lipid Utilization during High‐Fat Feeding Interrelationship Between Muscular Carbohydrate and Lipid Metabolism The Glucose–Fatty Acid, or Randle, Cycle The Existence of the Randle Cycle in Skeletal Muscle Possible Mechanisms Underlying the Glucose‐Fatty Acid Cycle in Skeletal Muscle A Role for Malonyl CoA in Fuel Selection in Skeletal Muscle Cells Defects in the Skeletal Muscle Fatty Acid Oxidative Pathway Concluding Remarks

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“…In the rat, training has been shown to reduce the content of TG in each muscle type (FroÈ berg 1969;Kaciuba-UsÂ ciøko et al 1981;Oscai et al 1982). In the present study, training reduced the TG content in the soleus muscle and the diaphragm and did not aect their content in either sections of the gastrocnemius muscles.…”

Section: Discussionmentioning

confidence: 99%

Effect of endurance training on the phospholipid content of skeletal muscles in the rat

Górski

¹

,

Żendzian-Piotrowska

²

,

Yf

³

et al. 1999

European Journal of Applied Physiology

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Only few data are available on the effect of training on phospholipid metabolism in skeletal muscles. The aim of the present study was to examine the effect of 6 weeks of endurance training on the content of particular phospholipid fractions and on the incorporation of blood-borne [14C]-palmitic acid into the phospholipids in different skeletal muscles (white and red sections of the gastrocnemius, the soleus and the diaphragm) of the rat. Lipids were extracted from the muscles and separated using thin-layer chromatography into the following fractions: sphingomyelin, phosphatidylcholine, phosphatidylserine, phosphatidylinositol, phosphatidylethanolamine, cardiolipin and neutral lipids (this fraction being composed mostly of triacylglycerols). It was found that training did not affect the content of any phospholipid fraction in soleus muscle. It increased the content of sphingomyelin in white gastrocnemius muscle, cardiolipin and phosphatidylethanolamine in red gastrocnemius muscle and phosphatidylinositol in white gastrocnemius muscle and diaphragm. The total phospholipid content in red gastrocnemius muscle of the trained group was higher than in the control group. Training reduced the specific activity of sphingomyelin and cardiolipin in all muscles, phosphatidylcholine in soleus, red, and white gastrocnemius muscles, phosphatidylserine in all muscles, phosphatidylinositol in all except the soleus muscle, and phosphatidylethanolamine in hindleg muscles, but not in the diaphragm compared to the corresponding values in the sedentary group. It was concluded that endurance training affects skeletal muscle phospholipid content and the rate of incorporation of the blood-borne [14C]palmitic acid into the phospholipid moieties.

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Muscle LPL Activity, Plasma and Muscle Triglycerides in Trained Thyroidectomized Rats

Cited by 9 publications

References 0 publications

Effect of exercise training on the fatty acid composition of lipid classes in rat liver, skeletal muscle, and adipose tissue

Effect of exercise training on the fatty acid composition of lipid classes in rat liver, skeletal muscle, and adipose tissue

Lipid Metabolism in Muscle

Effect of endurance training on the phospholipid content of skeletal muscles in the rat

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