Muscle Mass Is More Strongly Related to Hip Bone Mineral Density Than Is Quadriceps Strength or Lower Activity Level in Adults Over Age 50Year

Segal, Neil A.; Torner, James C.; Yang, Mei; Curtis, Jeffrey R.; Felson, David T.; Nevitt, Michael C.

doi:10.1016/j.jocd.2008.03.001

Cited by 48 publications

(68 citation statements)

References 32 publications

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“…Among physical performance, chair stand up time had correlated significantly with bone mineral density at all the measured sites, but the correlation was not as strong as for CC at hip. The finding is similar to prior studies showing that muscle mass is a better predictor of BMD compared to physical ability [34].…”

Section: Discussionsupporting

confidence: 90%

Relationship of calf circumference with bone mineral density and hip geometry: a hospital-based cross-sectional study

Singh

Gupta

2015

Arch Osteoporos

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Section: Discussionsupporting

confidence: 90%

Relationship of calf circumference with bone mineral density and hip geometry: a hospital-based cross-sectional study

Singh

Gupta

2015

Arch Osteoporos

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“…This finding was expected, as numerous other researchers have reported similar findings (3, 20, 29, 34, 35). Strong evidence supports the contribution of these factors to BMD.…”

Section: Discussionsupporting

confidence: 88%

“…However, the beneficial effects of exercise on BMD may be mitigated by the fact that the greater body mass of heavier individuals has a protective effect against bone loss because of the concomitant increases in longitudinal loading of the skeleton from the larger body mass as well as the greater muscle forces required to move a larger person (2, 3, 14, 29). Previous data confirm that elite highly-competitive elderly athletes have less body mass than do healthy age-matched controls (18).…”

Section: Introductionmentioning

confidence: 99%

Competitive Athletic Participation, Thigh Muscle Strength, and Bone Density in Elite Senior Athletes and Controls

McCrory

Salacinski

Sellhorst

et al. 2013

Journal of Strength and Conditioning Research

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The relationship between participation in highly competitive exercise, thigh muscle strength, and regional and total body bone mineral density (BMD) in elite senior athletes and healthy elderly controls was investigated. One hundred and four elite senior athletes (72.6±6.4yrs, 168.7±8.6cm, 72.6±13.5kg, 57M:47F) and 79 healthy controls (75.4±5.6yrs, 170.8±25.5cm, 79.5± 11.7kg, 46M:33F) participated in this cross-sectional study. Vitamin D and calcium intake were assessed via a recall survey. Isometric knee extension and flexion peak torque was measured via a custom strength measurement device. Total body and regional BMD of the hip, radius, and spine were assessed with DXA. For each BMD site assessed, multivariate linear regression analysis was performed in four steps (α=0.10) to examine the contribution of (1) age, sex, bodyweight, and calcium and vitamin D intake (2) group (elite senior athlete, control), (3) knee extension peak torque and (4) knee flexion peak torque on BMD. Sex, age, bodyweight, and calcium and vitamin D intake explained a significant amount of variance in BMD in each site. Group was not significant. Knee extension peak torque explained an additional 3.8% of the variance in hip BMD (p=0.06). Knee flexion peak torque was not correlated to BMD at any of the sites assessed. In conclusion, participation in highly competitive athletics was not related to total body or regional BMD. Age, sex, bodyweight, and vitamin D and calcium intake were significantly related to BMD at all of the sites assessed. Quadriceps strength contributed slightly to hip BMD. Our results imply that participation in highly competitive senior athletics does not have a protective effect on BMD, perhaps because of a lower bodyweight or other confounding factors.

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“…This is particularly the case among elderly men [23], because men have more muscle mass than women [24]. In line with this, studies have shown that lean mass was an independent contributor to hip bone mineral density [25, 26], especially in men [26, 27]. Furthermore, decreased lean mass may reduce testosterone level [28, 29], which has been shown to be positively associated with muscle strength and bone mineral density [28].…”

Section: Discussionmentioning

confidence: 95%

Association between change in body weight after midlife and risk of hip fracture—the Singapore Chinese Health Study

Ang¹,

Yuan

Koh

2015

Osteoporos Int

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Summary The relationship between change in body weight and risk of fractures is inconsistent in epidemiologic studies. In this cohort of middle-aged to elderly Chinese in Singapore, compared to stable weight, weight loss ≥10%over an average of 6 years is associated with nearly 40%increase in risk of hip fracture. Introduction Findings on the relationship between change in body weight and risk of hip fracture are inconsistent. In this study, we examined this association among middle-aged and elderly Chinese in Singapore. Methods We used prospective data from the Singapore Chinese Health Study, a population-based cohort of 63,257 Chinese men and women aged 45–74 years at recruitment in 1993–1998. Body weight and height were self-reported at recruitment and reassessed during follow-up interview in 1999–2004. Percent in weight change was computed based on the weight difference over an average of 6 years, and categorized as loss ≥10 %, loss 5 to <10 %, loss or gain <5 % (stable weight), gain 5 to <10 %, and gain ≥10 %. Multivariable Cox proportional hazards regression model was applied with adjustment for risk factors for hip fracture and body mass index (BMI) reported at follow-up interview. Results About 12 % experienced weight loss ≥10 %, and another 12% had weight gain ≥10 %. After a mean follow-up of 9.0 years, we identified 775 incident hip fractures among 42,149 eligible participants. Compared to stable weight, weight loss ≥10 % was associated with 39 % increased risk (hazard ratio 1.39; 95%confidence interval 1.14, 1.69). Such elevated risk with weight loss ≥10%was observed in both genders and age groups at follow-up (≤65 and >65 years) and in those with baseline BMI ≥20 kg/m2. There was no significant association with weight gain. Conclusions Our findings provide evidence that substantial weight loss is an important risk factor for osteoporotic hip fractures among the middle-aged to elderly Chinese.

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Muscle Mass Is More Strongly Related to Hip Bone Mineral Density Than Is Quadriceps Strength or Lower Activity Level in Adults Over Age 50Year

Cited by 48 publications

References 32 publications

Relationship of calf circumference with bone mineral density and hip geometry: a hospital-based cross-sectional study

Relationship of calf circumference with bone mineral density and hip geometry: a hospital-based cross-sectional study

Competitive Athletic Participation, Thigh Muscle Strength, and Bone Density in Elite Senior Athletes and Controls

Association between change in body weight after midlife and risk of hip fracture—the Singapore Chinese Health Study

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