2011
DOI: 10.1016/j.mito.2010.12.006
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Muscle mitochondrial capacity exceeds maximal oxygen delivery in humans

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Cited by 128 publications
(149 citation statements)
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“…However, dogs fall below the regression line indicating that dogs have a higher V O2max than predicted by their mitochondrial volume. The data presented here corroborate those findings in that the dogs have exceptionally high respiration per mg of tissue indicating excess capacity of mitochondria as has also been shown in humans [23]. It is also likely that Alaskan Huskies deviate more from this relationship than other canines, although this has not been directly tested.…”
Section: Discussionsupporting
confidence: 90%
“…However, dogs fall below the regression line indicating that dogs have a higher V O2max than predicted by their mitochondrial volume. The data presented here corroborate those findings in that the dogs have exceptionally high respiration per mg of tissue indicating excess capacity of mitochondria as has also been shown in humans [23]. It is also likely that Alaskan Huskies deviate more from this relationship than other canines, although this has not been directly tested.…”
Section: Discussionsupporting
confidence: 90%
“…The body's capacity to deliver oxygen to the muscles is usually thought to be the factor ‘limiting’ the VO 2max ,50 6466 since there is metabolic reserve in the mitochondrial capacity to use oxygen during maximal exercise67 and the fact that simply requiring more work to be done by increasing the workload does not increase the VO 2max 7 10 11. The finding that heart rate, breathing rate and ventilation at VO 2max were not different between protocols (table 1) excludes the possibility that the excess VO 2 is the result simply of extra mechanical work done by the heart or respiratory muscles.…”
Section: Discussionmentioning
confidence: 99%
“…3,4 In addition, evidence has been put forth that muscle mitochondrial oxidative capacity at peak two-leg exercise exceeds maximal O 2 delivery in humans. 5 Overall, these findings demonstrate the existence of a large metabolic reserve, virtually excluding the possibility that the metabolic aerobic machinery of skeletal muscle is the limiting factor of peak aerobic performance. Another possible limiting factor to VO 2max is peripheral O 2 diffusing capacity, but in this regard, the available evidence is less clear.…”
mentioning
confidence: 82%