Muscle plasticity of aged subjects in response to electrical stimulation training and inversion and/or limitation of the sarcopenic process

Paillard, Thierry

doi:10.1016/j.arr.2018.05.002

Cited by 27 publications

(23 citation statements)

References 123 publications

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“…In this regard, the use of neuromuscular electrostimulation (NMES), which is usually used in chronic diseases with secondary sarcopenia, looks promising. [ 4 , 5 ] It has been shown that the use of NMES is not only safe in patients immediately after cardiovascular surgery, [ 6 , 7 ] but also reduces skeletal muscle proteolysis and weakness. [ 8 ] In patients with early activation after cardiovascular surgery, the use of NMES did not lead to additional improvement in muscle strength, which could be due to uncontrolled physical activity in the control.…”

Section: Introductionmentioning

confidence: 99%

Neuromuscular electrical stimulation in early rehabilitation of patients with postoperative complications after cardiovascular surgery

Сумин¹,

Олейник²,

Безденежных³

et al. 2020

Medicine

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Background: To evaluate the effectiveness of neuromuscular electrical stimulation (NMES) in early rehabilitation of patients with postoperative complications after cardiovascular surgery. Methods: 37 patients (25 men and 12 women) aged 45 to 70 years with postoperative complications after cardiovascular surgery were included in the study. Eighteen patients underwent NMES daily since postoperative day 3 until discharge in addition to standard rehabilitation program (NMES group), and 19 patients underwent standard rehabilitation program only (non-NMES group). The primary outcome was the knee extensors strength at discharge in NMES group and in control. Secondary outcomes were the handgrip strength, knee flexor strength, and cross-sectional area (CSA) of the quadriceps femoris in groups at discharge. Results: Baseline characteristics were not different between the groups. Knee extensors strength at discharge was significantly higher in the NMES group (28.1 [23.8; 36.2] kg on the right and 27.45 [22.3; 33.1] kg on the left) than in the non-NMES group (22.3 [20.1; 27.1] and 22.5 [20.1; 25.9] kg, respectively; P < .001). Handgrip strength, knee flexor strength, quadriceps CSA, and 6 minute walk distance at discharge in the groups had no significant difference. Conclusions: This pilot study shows a beneficial effect of NMES on muscle strength in patients with complications after cardiovascular surgery. The use of NMES showed no effect on strength of non-stimulated muscle, quadriceps CSA, and distance of 6-minute walk test at discharge. Further blind randomized controlled trials should be performed with emphasis on the effectiveness of NEMS in increasing muscle strength and structure in these patients.

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Section: Introductionmentioning

confidence: 99%

Neuromuscular electrical stimulation in early rehabilitation of patients with postoperative complications after cardiovascular surgery

Сумин¹,

Олейник²,

Безденежных³

et al. 2020

Medicine

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“…Molecular wise EMS stimulates not only anabolic pathways (e.g. secretion of IGF‐1) but also negatively modulates catabolic metabolism (expression of MafBx or MuRF1), thereby increasing muscle mass (reviewed in Paillard). In addition, EMS effectively downregulated myostatin mRNA, decreased the production of reactive oxygen species, and increased the regenerative capacity of satellite cells …”

Section: Human Datamentioning

confidence: 99%

“…What evidence is available from human clinical studies supporting the therapeutic effect of electrical stimulation? As outlined by many studies, neuromuscular electrical stimulation (NMES) may be an effective alternative approach to enhance lower limb muscle mass and force in numerous diseases associated with muscle atrophy (summarized in Paillard). A cohort profiting probably most from EMS are sarcopenic individuals, unable or unwilling to perform regular exercise.…”

Section: Human Datamentioning

confidence: 99%

Electromyostimulation to fight atrophy and to build muscle: facts and numbers

Adams

2018

J cachexia sarcopenia muscle

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In recent years, electrical myostimulation (EMS) is becoming more and more popular to increase muscle function and muscle weight. Especially it is applied in healthy individual after injury to rebuild muscle mass and in severely atrophic patients who are not able or willing to perform conventional exercise training programs. Studies in experimental models as well as in human subjects confirmed that EMS can increase muscle mass by around 1% and improve muscle function by around 10–15% after 5–6 weeks of treatment. Despite a severe increase in circulating creatine kinase during the first session, EMS can be regarded as a safe therapeutic intervention. At the molecular level, EMS improves the anabolic/catabolic balance and stimulates the regenerative capacity of satellite cells. EMS intensity should be as high as individually tolerated, and a minimum of three sessions per week [large pulses (between 300–450 μs), high frequency (50–100 Hz in young and around 30 Hz in older individuals)] for at least 5–6 weeks should be performed. EMS improved functional performances more effectively than voluntary training and counteracted fast type muscle fibre atrophy, typically associated with sarcopenia. The effect of superimposing EMS on conventional exercise training to achieve more muscle mass and better function is still discussed controversially. Nevertheless, EMS should not be regarded as a replacement of exercise training per se, since the beneficial effect of exercise training is not just relying on building muscle mass but it also exerts positive effects on endothelial, myocardial, and cognitive function.

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“…However, very old people (even healthy ones) are often either unable or unwilling to perform conventional exercise programs (Paillard, 2018 ). Evidence suggests that the lower the physical activity volume, the lower the bone mineral density.…”

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confidence: 99%

“…However, although the osteogenic effects of NMES remain uncertain, the question still deserves to be raised since the regular/chronic application of NMES has numerous advantages related to the muscle function and thus in the fight against sarcopenia (Paillard et al, 2004 ; Kern et al, 2014 ; Barberi et al, 2015 ; Paillard, 2018 ). On the one hand, NMES can be clinically and preventively substituted for voluntary exercise in older subjects to stimulate their muscle function (Von Stengel et al, 2015 ).…”

mentioning

confidence: 99%

Muscle plasticity of aged subjects in response to electrical stimulation training and inversion and/or limitation of the sarcopenic process

Cited by 27 publications

References 123 publications

Neuromuscular electrical stimulation in early rehabilitation of patients with postoperative complications after cardiovascular surgery

Neuromuscular electrical stimulation in early rehabilitation of patients with postoperative complications after cardiovascular surgery

Electromyostimulation to fight atrophy and to build muscle: facts and numbers

Regular Muscle Electrical Stimulation Could Act Favorably On Bone Mineral Density in Healthy Aged Subjects

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