Muscle Relaxant Properties of Aqueous Extract of<i>Lippia multiflora</i>

Noamesi, B. K.; Bamgbose, S. O. A.

doi:10.1055/s-2007-969471

Cited by 12 publications

(8 citation statements)

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“…The three preparations used in the toxicity study were presented to the mice at high concentration, thus the presence of xanthine may have over-stimulated the mice and led to a depressant phase without the typical initial stimulation phase with clonic convulsions, which is a rapid alternating contraction and relaxation of muscles. For instance, Noamesi et al (1985a) demonstrated tranquilizer and analgesic effects of L. multiflora in rats, similar to those of diazepam, after doses ranging from 200 to 1,200 mg/kg of L. multiflora lyophilisated powder obtained from an infusion of dried leaves dissolved in NaCl administered by either the intraperitoneal or oral route. In that experiment, the tranquilizer and analgesic phase was preceded by a precocious ataxic phase and the quality of the symptoms and signs observed were dose dependant unlike in the present study.…”

Section: Discussionmentioning

confidence: 97%

“…Xanthine is a demethylated derivative of caffeine with pharmacological actions such as central nervous system (CNS) stimulation, relaxation of smooth muscle (especially bronchial muscle), myocardial stimulation, peripheral vasoconstriction and diuresis. Lippia multiflora, a species found in many parts of sub-Saharan Africa, is also known to contain xanthine (Noamesi et al 1985a).…”

Section: Discussionmentioning

confidence: 99%

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Acaricidal efficacy against cattle ticks and acute oral toxicity of Lippia javanica (Burm F.) Spreng

Madzimure

Nyahangare

Hamudikuwanda

et al. 2010

Trop Anim Health Prod

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In search for low-cost, safe and environmentally benign plant-based alternatives to commercial pesticides, the efficacy of Lippia javanica aqueous leaf extracts in controlling ticks on cattle, acute oral toxicity in mice and phytochemistry were evaluated. L. javanica aqueous leaf extracts at 10% and 20% w/v were effective at controlling cattle ticks but not as good as an amitraz-based acaricide Tickbuster®. However, they can provide an effective tick control option where synthetic products are unavailable or unaffordable, particularly in remote parts of southern Africa. Peripheral blood samples collected showed no haemoparasites in treated cattle implying that animals did not suffer from clinical tick-borne diseases. The leaf aqueous extracts of L. javanica were tested for toxicity in BALB/c mice. While anecdotal evidence suggests L. javanica has low mammalian toxicity, within 48 h all mice fed with the L. javanica leaf aqueous extract at 12.5-37.5% v/v were lethargic, and overall mortality was 37.5% (n=24). Thus, despite their apparent safety, water extracts of L. javanica leaves may have deleterious health implications on humans and animals if consumed at very high doses. Many compounds have been identified from L. javanica including an array of phenolic glycosides, flavonoids and essential oils but none of these are known to have acute toxic properties.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Acaricidal efficacy against cattle ticks and acute oral toxicity of Lippia javanica (Burm F.) Spreng

Madzimure

Nyahangare

Hamudikuwanda

et al. 2010

Trop Anim Health Prod

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“…It has been shown in an earlier investigation (3), that no evidence has been found to support a central nervous system activity of the extract that might influence its blood pressure lowering effect as was the case with regards to drugs like clonidine and alpha-methyldopa. However, in the same investigation (3) evidence was produced to support a skeletal muscle relaxant property for the extract.…”

Section: Resultsmentioning

confidence: 92%

“…The decoction has, in addition to the antihypertensive effect, been observed to produce a reduction in body tension similar to a tranquilizing effect. This effect, which has been investigated pharmacologically (3) was found to be as a result of a muscle relaxant property of the leaf extract.…”

Section: Introductionmentioning

confidence: 97%

The Vascular Actions of Aqueous Extract ofLippia multiflora

Noamesi¹,

Bamgbose²

1985

Planta Med

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Intravenously administered aqueous leaf extract (6.3 to 12.5 mg/kg) in anaesthetised cats and (3.2 to 6.3 mg/kg) in anaesthetised rats, produced a significant fall (P < 0.05, n 10) in the mean, systolic and diastolic blood pressure by as much as 75 mm Hg in cats and 35 10.00mm Hg in rats. On the raised arterial perfusion pressure of the rabbit central ear artery preparation, the extract (12.5-50 sg) produced a transient rise in perfusion pressure, which was followed by a more significant and prolonged fall in the perfusion pressure. Phentolamine (1.0 sg/ml) antagonised the transient rise and propranolol (1.0 tg/ml abolished the fall in perfusion pressure. The results suggested: that vasodilatation, resulting from a combination of alpha-adrenoceptor blockade and beta-adrenoceptor stimulant action of the extract, aided by skeletal muscle relaxation might be responsible for the blood pressure lowering effect of the extract.

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“…Bouquet et Debray (1974) ont indiqué qu'elle est communément appelée «thé de savane» ou «thé de Gambie» et traditionnellement utilisée pour soigner les affections bronchiques, les accès fébriles, la rhinopharyngite, les conjonctivites et les ictères. De plus les travaux de Silou et al (1992) ont montré que le thé de savane est un hypotenseur qui présente des propriétés pesticides Noamesi et al (1985) ont rapporté que l'extrait aqueux des feuilles de L. multiflora possèdent un effet calmant. Dans les communautés rurales d'Afrique occidentale et centrale, Jim et al (2004) ont observé que le thé de Lippia multiflora consommé après les travaux champêtres permet une bonne détente et un sommeil réparateur.…”

Section: Introductionunclassified

<i>Lippia multiflora</i> (verbenaceae) en Côte d’Ivoire : point des premiers resultats de recherche et Enjeu cultural

Konan¹,

Turquin²,

Attah³

et al. 2011

Agronomie Africaine

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RESUMELippia multiflora (Verbenaceae) ou thé de savane pousse naturellement dans les régions de savane en Côte d'Ivoire. Dans le cadre de la diversification des cultures en Côte d'Ivoire, des recherches récentes ont été conduites en vue de la caractérisation de sa composition, sa domestication et sa valorisation, ont abouti à des résultats. Des résultats de recherche couvrant les années 1996 à 2009 de travaux sur Lippia multiflora ont concerné cette analyse. Ceux-ci concernent différents champs disciplinaires dont des évaluations pédologiques, agrophysiologiques, physicochimiques et médicinales effectués en Côte d'Ivoire. Les particularités de cette plante en interaction avec les paramètres environnementaux de sa culture mises en valeur sont discutées. ABSTRACT Lippia multiflora (VERBENACEAE) IN CÔTE D'IVOIRE : PRELIMINARY RESEARCH RESULTS AND CULTURE CHALLENGEAs part of diversification of crops in Côte d'Ivoire, studies have been conducted for the domestication and exploitation of Lippia multiflora or savannah tea. Pedological evaluations in different areas, morphological, physicochemical and medicinal studies have been made. It appears that the plant grows on several types of soils that are sandy clay to sandy loam and slightly acid. The roots are found mostly within 30 cm of soil. Mulching paths and the input of nitrogen fertilization (from 500 to 1500 kg/ha -1 ) promote rapid growth (> 150 cm after 10 d) and obtaining a large biomass (> 8 t.ha -1 ). Young leaves are richer in protein than adults. In Côte d'Ivoire, there are two plant chemotypes depending on the content major compounds : 1,8 cineole, geranial and á-terpineol with therapeutic cons of diarrhea and malaria.

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Muscle Relaxant Properties of Aqueous Extract ofLippia multiflora

Cited by 12 publications

References 0 publications

Acaricidal efficacy against cattle ticks and acute oral toxicity of Lippia javanica (Burm F.) Spreng

Acaricidal efficacy against cattle ticks and acute oral toxicity of Lippia javanica (Burm F.) Spreng

The Vascular Actions of Aqueous Extract ofLippia multiflora

<i>Lippia multiflora</i> (verbenaceae) en Côte d’Ivoire : point des premiers resultats de recherche et Enjeu cultural

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