Muscle weakness as an additional criterion for grading sarcopenia‐related prognosis in patients with cancer

Cereda, Emanuele; Tancredi, Richard; Klersy, Catherine; Lobascio, Federica; Crotti, Silvia; Masi, Sara De; Cappello, Silvia; Stobäus, N.; Tank, Maja; Cutti, Sara; Arcaini, Luca; Bonzano, Elisabetta; Colombo, Sara; Pedrazzoli, Paolo; Norman, Kristina; Caccialanza, Riccardo

doi:10.1002/cam4.4362

Cited by 6 publications

(4 citation statements)

References 56 publications

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“…HGS is an inexpensive and simple measurement method that can be used in clinical practice [8]. HGS has been reported to be a valuable prognostic factor and can provide important additional prognostic information for malignancies [16,17]. However, muscle mass and strength differ depending on the patient's body size, which means that HGS needs to be standardized to better assess the impact of HGS on prognosis.…”

Section: Discussionmentioning

confidence: 99%

Comparison of absolute and relative handgrip strength to predict cancer prognosis: A prospective multicenter cohort study

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Comparison of absolute and relative handgrip strength to predict cancer prognosis: A prospective multicenter cohort study

et al. 2022

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“…The relationship between body composition and pharmacokinetics of chemotherapy is also well established [ 45 ]. Recently, Cereda et al demonstrated that muscle weakness was a better predictor of survival than skeletal muscle mass estimated by bioelectrical impedance analysis [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Low Handgrip Strength with Chemotherapy Toxicity in Digestive Cancer Patients: A Comprehensive Observational Cohort Study (FIGHTDIGOTOX)

et al. 2022

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In the FIGHTDIGO study, digestive cancer patients with dynapenia experienced more chemotherapy-induced neurotoxicities. FIGHTDIGOTOX aimed to evaluate the relationship between pre-therapeutic handgrip strength (HGS) and chemotherapy-induced dose-limiting toxicity (DLT) or all-grade toxicity in digestive cancer patients. HGS measurement was performed with a Jamar dynamometer. Dynapenia was defined according to EWGSOP2 criteria (<27 kg (men); <16 kg (women)). DLT was defined as any toxicity leading to dose reduction, treatment delay, or permanent discontinuation. We also performed an exploratory analysis in patients below the included population’s median HGS. A total of 244 patients were included. According to EWGSOP2 criteria, 23 patients had pre-therapeutic dynapenia (9.4%). With our exploratory median-based threshold (34 kg for men; 22 kg for women), 107 patients were dynapenic (43.8%). For each threshold, dynapenia was not an independent predictive factor of overall DLT and neurotoxicity. Dynapenic patients according to EWGSOP2 definition experienced more hand-foot syndrome (p = 0.007). Low HGS according to our exploratory threshold was associated with more all-grade asthenia (p = 0.014), anemia (p = 0.006), and asthenia with DLT (p = 0.029). Pre-therapeutic dynapenia was not a predictive factor for overall DLT and neurotoxicity in digestive cancer patients but could be a predictive factor of chemotherapy-induced anemia and asthenia. There is a need to better define the threshold of dynapenia in cancer patients.

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“…8 In particular, it has been observed that handgrip strength assessment is a reliable survival predictor associated with body composition variations, being also a good indicator of functional capacities in chronic diseases. 9 In oncology, low handgrip strength levels are associated with fatigue, impaired QoL, treatment-related toxicity and higher mortality. 10 11 National and international guidelines on clinical nutrition in oncology-including those issued by the Italian Ministry of Health in 2017 12 -underline the utility of early evaluation of nutritional status in patients with cancer and of a prompt and appropriate nutritional support, whenever indicated, in order to prevent or treat malnutrition, improve patients' clinical outcomes and QoL, and increase the efficacy and tolerability of cancer treatments.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

“…Sarcopenia (ie, the loss of skeletal muscle (SM) and strength) is the main issue which contributes to functional deterioration in patients with cancer 8. In particular, it has been observed that handgrip strength assessment is a reliable survival predictor associated with body composition variations, being also a good indicator of functional capacities in chronic diseases 9. In oncology, low handgrip strength levels are associated with fatigue, impaired QoL, treatment-related toxicity and higher mortality 10 11…”

Section: Introductionmentioning

confidence: 99%

Multicentric, observational, longitudinal study for the evaluation of nutritional management implications in newly diagnosed Italian cancer patients: the Italian Registry of Malnutrition in Oncology (IRMO)

Bosetti,

Casirati,

Da Prat

et al. 2023

BMJ Open

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BackgroundMalnutrition is a frequent problem in oncology and is associated with reduced response to cancer treatments, increased drug-related toxicity, higher rates of clinical complications, reduced quality of life (QoL) and worse prognosis. Guidelines on clinical nutrition in oncology emphasise the usefulness of early assessment of nutritional status for a prompt identification of malnutrition and the implementation of effective interventions, but no real-world clinical data are available on the adequate management of nutritional support in patients with cancer in Italy.Methods and analysisThis is an observational, longitudinal, multicentre registry of patients with a new diagnosis of cancer or metastatic disease, candidates for active treatment. They will be identified in at least 15 Italian oncological centres, members of the Alliance Against Cancer Working Group ‘Survivorship Care and Nutritional Support’. At least 1500 patients with cancer are expected to be enrolled each year. Detailed clinical and nutritional data will be collected by oncologists and clinical nutritionists during the visits foreseen in the clinical practice, through an ad hoc developed digital platform (e-Nutracare). The effects of malnutrition and nutritional support—at diagnosis and during follow-up—on overall survival and progression-free survival, as well as on patients’ symptoms and QoL, will be investigated.Ethics and disseminationThe study protocol was approved by the Ethics Committee of the Fondazione IRCCS Policlinico San Matteo, Pavia, Italy and from the Ethics Committees of all other participating centres. An informed consent will be obtained from each patient enrolled in the study. Study findings will be disseminated through peer-reviewed journals, conferences and patients with cancer or professional associations. The registry will allow a better monitoring of the nutritional status of patients with cancer, promoting adequate and sustainable nutritional support, with the ultimate goal of improving the care and prognosis of these patients.

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Muscle weakness as an additional criterion for grading sarcopenia‐related prognosis in patients with cancer

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 6 publications

References 56 publications

Comparison of absolute and relative handgrip strength to predict cancer prognosis: A prospective multicenter cohort study

Comparison of absolute and relative handgrip strength to predict cancer prognosis: A prospective multicenter cohort study

Association of Low Handgrip Strength with Chemotherapy Toxicity in Digestive Cancer Patients: A Comprehensive Observational Cohort Study (FIGHTDIGOTOX)

Multicentric, observational, longitudinal study for the evaluation of nutritional management implications in newly diagnosed Italian cancer patients: the Italian Registry of Malnutrition in Oncology (IRMO)

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