Muscodor sutura, a novel endophytic fungus with volatile antibiotic activities

Kudalkar, Priyanka; Strobel, Gary A.; Syed, Rabbani; Geary, Brad; Sears, Joe

doi:10.1007/s10267-011-0165-9

Cited by 77 publications

(46 citation statements)

References 14 publications

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“…Although there was still need to confirm this hypothesis by performing for instances bioassays, the joint action of these VOCs seems to have potential utility in the treatment of infectious diseases caused by bacteria and yeasts. In fact, VOCs extracted from endophytic fungi have been reported to have antimicrobial effects against a variety of human and plant pathogens (Kudalkar et al 2012;Mitchell et al 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Endophytic fungi are one of the potential sources of novel antimicrobial compounds, due to chemical diversity of their secondary metabolites. So far, studies reported a wide range of novel antimicrobial compounds produced by endophytic fungi belonging to diverse structural classes, including alkaloids, peptides, steroids, terpenoids, phenols, phenylpropanoids, aliphatic compounds, polyketides, quinones and flavonoids (Mousa and Raizada 2013;Yu et al 2010), as well as volatile organic compounds (VOCs) such as esters, lipids, alcohols, acids, ketones, among others (Banerjee et al 2010;Kudalkar et al 2012). However, several studies have shown that the plant host, and ultimately its metabolism, influences the synthetic ability of endophytes (Strobel 2006;Ul-Hassan et al 2012), which could prevent these microorganisms from being used in a commercial production of antimicrobial compounds (Kusari et al 2014).…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial activity of endophytic fungi from olive tree leaves

Malhadas

Malheiro

Pereira

et al. 2017

World J Microbiol Biotechnol

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species. In the next step, various organic extracts from both A. alternata mycelium and cultured broth were prepared; being ethyl acetate extracts displayed the widest spectrum of anti-microorganisms at a minimum inhibitory concentration ≤0.095 mg/mL. The volatile composition of the fungi that displayed the highest (A. alternata) and the lowest (P. canescens) antimicrobial activity against yeasts revealed the presence of six volatiles, being the most abundant components (3-methyl-1-butanol and phenylethyl alcohol) ascribed with antimicrobial potentialities. Overall the results highlighted for the first time the antimicrobial potential of endophytic fungi from O. europaea and the possibility to be exploited for their antimicrobial agents.Abstract In this study, the antimicrobial potential of three fungal endophytes from leaves of Olea europaea L. was evaluated and the host plant extract effect in the antimicrobial activity was examined. The volatile compounds produced by endophytes were identified by GC/MS and further correlated with the antimicrobial activity. In potato dextrose agar, both Penicillium commune and Penicillium canescens were the most effective inhibiting Gram-positive and -negative bacteria (up to 2.7-fold compared to 30 µg/ mL chloramphenicol), whereas Alternaria alternata was most effective inhibiting yeasts (up to 8.0-fold compared to 25 μg/mL fluconazole). The presence of aqueous leaf extract in culture medium showed to induce or repress the antimicrobial activity, depending on the endophytic Electronic supplementary material The online version of this article

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of endophytic fungi from olive tree leaves

Malhadas

Malheiro

Pereira

et al. 2017

World J Microbiol Biotechnol

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“…C. lusitanica [65] Thujopsanol, thujopsene Xylaria sp. C. lusitanica [65] M. sutura P. trifidi [71] Ylangene Phoma sp. L. tridentata [66] Zingiberene Xylaria sp.…”

Section: Albusmentioning

confidence: 99%

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

2015

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Abstract:It is known that plant-based ethnomedicine represented the foundation of modern pharmacology and that many pharmaceuticals are derived from compounds occurring in plant extracts. This track still stimulates a worldwide investigational activity aimed at identifying novel bioactive products of plant origin. However, the discovery that endophytic fungi are able to produce many plant-derived drugs has disclosed new horizons for their availability and production on a large scale by the pharmaceutical industry. In fact, following the path traced by the blockbuster drug taxol, an increasing number of valuable compounds originally characterized as secondary metabolites of plant species belonging to the Spermatophyta have been reported as fermentation products of endophytic fungal strains. Aspects concerning sources and bioactive properties of these compounds are reviewed in this paper.

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“…(2), according to searches in UNITE database using DNA sequences of internal transcribed spacer (ITS) ( Table 1). Muscodor is a genus of sterile endophytic fungi, all species of this genus were characterized by the production of volatile organic compounds (VOCs) that inhibit the growth of other microorganisms (STROBEL et al, 2001a;STROBEL, 2006b;STROBEL, 2011c;STINSON et al, 2003;JIMENEZ, 2004;MANKER 2005;MERCIER et al, 2007;WORAPONG;STROBEL, 2009;ZHANG et al, 2010;SUWANNARACH et al, 2012;KUDALKAR et al, 2012;SAXENA et al, 2015).…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial activity of endophytic fungi from coffee plants

Monteiro¹,

Alves²,

Queiroz³

et al. 2017

Biosci. J.

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Endophytic fungi are a promising source for discovery of compounds with biotechnological potential. The aim of this study was to select and identify endophytic fungi from Coffea arabica that produce volatile organic compounds (VOCs), evaluate the effect of the VOCs produced by endophytic fungi on the growth of Rhizoctonia solani, Fusarium oxysporum, Phoma sp., Botrytis cinerea, Fusarium solani, Fusarium verticillioides, Cercospora coffeicola and Pestalotia longisetula, and select endophytic fungi with potential for biological control of Aspergillus ochraceus inoculated in coffee beans and F. verticillioides inoculated in corn seeds. An isolate of Muscodor albus was used as selection tool for VOC producing fungi. Among the 400 endophytic fungi isolates, 11 were able to grow in the presence of VOCs produced by M. albus. These fungi were identified as Muscodor spp. (9) and Simplicillium sp. according to searches in UNITE database using DNA sequences of internal transcribed spacer (ITS). The VOC's produced by endophytic fungi inhibited the growth the phytopathogenic fungi with different efficacies, compared to the control. The VOCs produced by Muscodor coffeanum (COAD 1842) showed fungicidal effect against A. ochraceus on coffee beans. Six endophytic fungi completely inhibited growth of F. verticillioides inoculated in corn seeds. This study demonstrates that the volatile-compound producing endophytic fungi, isolated from Coffea arabica, are promising sources of bioactive compounds.

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Muscodor sutura, a novel endophytic fungus with volatile antibiotic activities

Cited by 77 publications

References 14 publications

Antimicrobial activity of endophytic fungi from olive tree leaves

Antimicrobial activity of endophytic fungi from olive tree leaves

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

Antimicrobial activity of endophytic fungi from coffee plants

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