Muscular Apparatus of the Ovarian Follicle

Talbot, Prudence

doi:10.1007/978-1-4615-3944-5_9

Cited by 6 publications

(6 citation statements)

References 74 publications

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“…Important contributions to the role of thecal smooth muscle cells in the ovulatory process have been made by studies in the hamster [4]. It has been demonstrated that these cells contract prior to ovulation [5,25,26].…”

Section: Discussionmentioning

confidence: 99%

“…In mammals, contractile activity of the follicular wall is caused by the smooth muscle cells of the theca externa [1][2][3][4]. Important contributions to the role of thecal smooth muscle cells in the ovulatory process have been made by studies in the hamster [4].…”

Section: Discussionmentioning

confidence: 99%

“…In vitro contractile experiments have been carried out in various vertebrate species, mainly in eutherian mammals [1][2][3][4]. Most of these experiments have been used to investigate the effects of different metabolic and pharmacological compounds on the contractility of the follicular wall.…”

Section: Discussionmentioning

confidence: 99%

“…They termed this activity the "relaxationinduced follicular wall contraction." The maintenance of intrafollicular pressure by the contracting smooth muscle against the enzymatically weakened apex brings about the final thinning of the apex and forces the oocyte through the rupture site [4].…”

Section: Discussionmentioning

confidence: 99%

“…The muscular apparatus of the ovary, mainly of the preovulatory follicle, has been investigated more thoroughly in eutherian mammals than in any other group of vertebrates [1][2][3][4]. Possible functions of the contractile apparatus of mammalian ovarian follicles include aid in follicular rupture [5], collapse of the follicular wall and corpus luteum formation [6], and compaction of the follicle during atresia [7].…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Study of the Contractility of the Wall of the Preovulatory Follicle in the Japanese Quail1

Nassauw

Sys

Harrisson

et al. 1993

Biology of Reproduction

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In the present study, we examined in vitro the potassium-induced contractions of isolated parts of the wall of the quail preovulatory follicle through use of an electromagnetic force-length transducer system. We studied longitudinal and transverse strips of the whole wall, of the theca, and of the outer layer (tunica albuginea and surface epithelium). It was observed that force development and shortening of strips of the whole wall and those of the theca are similar. Statistical analysis of maximal isometric force, peak shortening length, and percentage of reduction of follicular volume showed that the orientation of strips is without importance. Results from different orientations were pooled, and the different layers were compared statistically. The general result of this analysis was that the contractile activity of the outer layer was significantly lower than the performance of either the whole wall or the theca. We concluded that contraction of the follicular wall is mainly dependent on the contractile activity of the theca externa. This contractile system is comparable to that of mammals. We suggest that the main function of the theca externa during ovulation is to maintain a constant intrafollicular pressure.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

In Vitro Study of the Contractility of the Wall of the Preovulatory Follicle in the Japanese Quail1

Nassauw

Sys

Harrisson

et al. 1993

Biology of Reproduction

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In vitro analysis of oocyte cumulus complex pickup rate in the hamster Mesocricetus auratus

et al. 1997

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Increased formation of corpora lutea in neurokinin 1‐receptor deficient mice

Löffler¹,

Schulz²,

Hunt

et al. 2004

Molecular Reproduction Devel

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There is evidence to suggest that the tachykinin-receptor system may be involved in female reproduction. Recently, we have shown that the mRNA transcripts of the preprotachykinin-A which encodes substance P (SP), a member of the tachykinin family, and of NK1-R (preferred receptor of SP) are expressed in the bovine corpus luteum (CL) of early developmental stage. The question arises whether the system is expressed at the protein level and influences the ovulatory process and CL formation. For this reason, ovaries from a mouse mutant in which the NK1-R gene had been disrupted were studied. By using RT-PCR, mRNA expression of NK1-R was confirmed in both the ovary and the uterus of wild-type mice. Weaning frequency and litter size, as recorded over 6 months, were similar in both groups. However, counting of CL in serial paraffin sections revealed a significant higher number of CL in the NK1-R deficient mice in comparison to the wild-type group (P < 0.01). The increased formation of CL in NK1-R deficient mice corresponded to a considerable number of CL with retained oocyte not found in ovaries of the wild-type group. We conclude: The CL with a retained oocyte may indicate that the muscular apparatus of the preovulatory follicle plays a role in oocyte expulsion and that contractility of the follicle wall is deficient in the mutant group. Our observation may have implications for the luteinized unruptured follicle syndrome in humans.

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Muscular Apparatus of the Ovarian Follicle

Cited by 6 publications

References 74 publications

In Vitro Study of the Contractility of the Wall of the Preovulatory Follicle in the Japanese Quail1

In Vitro Study of the Contractility of the Wall of the Preovulatory Follicle in the Japanese Quail1

In vitro analysis of oocyte cumulus complex pickup rate in the hamster Mesocricetus auratus

Increased formation of corpora lutea in neurokinin 1‐receptor deficient mice

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