Mushroom Consumption and Incident Dementia in Elderly Japanese: The Ohsaki Cohort 2006 Study

Zhang, Shu; Tomata, Yasutake; Sugiyama, Kemmyo; Sugawara, Yumi; Tsuji, Ichiro

doi:10.1111/jgs.14812

Cited by 48 publications

(49 citation statements)

References 48 publications

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“…Dietary ET does cross the blood–brain barrier, since it can be measured in human cerebrospinal fluid and postmortem brain samples (our unpublished data; also see ) and readily enters the brain when administered to mice . A Japanese study has found a correlation between increased intake of mushrooms (one of the most important dietary sources of ET ; Table ) and lower incidence of dementia. However, mushrooms are known to contain a wide range of possibly bioactive compounds that could account for this observation.…”

Section: Ergothioneine As a Potential Treatment For Diseasesmentioning

confidence: 82%

“…readily enters the brain when administered to mice [33]. A Japanese study [74] has found a correlation between increased intake of mushrooms (one of the most important dietary sources of ET [27-29]; Table 1) and lower incidence of dementia. However, mushrooms are known to contain a wide range of possibly bioactive compounds that could account for this observation.…”

Section: Neurodegenerative Diseasesmentioning

confidence: 99%

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Ergothioneine – a diet‐derived antioxidant with therapeutic potential

2018

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Ergothioneine is a thiol/thione molecule synthesised only by some fungi and bacteria. Nonetheless, it is avidly taken up from the diet by humans and other animals through a transporter, OCTN1, and accumulates to high levels in certain tissues. Ergothioneine is not rapidly metabolised, or excreted in urine and is present in many, if not all, human tissues and body fluids. Ergothioneine has powerful antioxidant and cytoprotective properties in vitro and there is evidence that the body may concentrate it at sites of tissue injury by raising OCTN1 levels. Decreased blood and/or plasma levels of ergothioneine have been observed in some diseases, suggesting that a deficiency could be relevant to the disease onset or progression. This brief Review explores the possible roles of ergothioneine in human health and disease.

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Section: Ergothioneine As a Potential Treatment For Diseasesmentioning

confidence: 82%

Section: Neurodegenerative Diseasesmentioning

confidence: 99%

Ergothioneine – a diet‐derived antioxidant with therapeutic potential

2018

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“…individuals who had impairment with mild cognitive dysfunction, but who had no dementia-related symptoms or behavioral disturbance and were capable of living independently are ranked as I; and individuals ranked as greater than or equal to II or M (rank M means that the individual has severe dementia-related symptoms and requires medical services) are regarded as having incident dementia. 16,17 In previous studies, the dementia scale of LTCI certification has been shown to be well-correlated with the Hasegawa's Dementia Scale (HDS-R) (Spearman's rank correlation coefficient ρ = −0.732)…”

Section: Key Pointsmentioning

confidence: 98%

“…16,17 In previous studies, the dementia scale of LTCI certification has been shown to be well-correlated with the Hasegawa's Dementia Scale (HDS-R) (Spearman's rank correlation coefficient ρ = −0.732) 16,17 In previous studies, the dementia scale of LTCI certification has been shown to be well-correlated with the Hasegawa's Dementia Scale (HDS-R) (Spearman's rank correlation coefficient ρ = −0.732)…”

Section: Key Pointsmentioning

confidence: 99%

Physical activity and incident dementia in older Japanese adults: The Okayama study

Liu

Mitsuhashi

Yamakawa

et al. 2019

Int J Geriat Psychiatry

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Objective To evaluate the association between regular physical activity and the risk of incident dementia in older Japanese adults. Methods This was a retrospective cohort study performed in Okayama City, Japan. Overall, 51 477 older Japanese adults were followed from 2008 to 2014. A health checkup questionnaire was used to assess regular physical activity. The Dementia Scale of long‐term care insurance was used as a measure of incident dementia. Cox proportional hazard models were used to calculate adjusted hazard ratios, with their 95% confidence intervals, for the incidence of dementia across the categories of physical activity. Results During a 7‐year follow‐up, 13 816 subjects were considered as having incident dementia. Compared with participants who performed physical activity less than or equal to one time per week, the multivariate adjusted hazard ratio values (95% confidence intervals) for participants who performed physical activity greater than or equal to two times per week but not every day and those who performed physical activity every day were 0.79 (0.75‐0.84) and 0.94 (0.89‐0.98), respectively. The interaction of physical activity and sex was statistically significant (P < .01). In subgroup analysis, the multivariate‐adjusted hazard ratio values (95% confidence intervals) remained low, at 0.76 (0.70‐0.84) in males and 0.81 (0.76‐0.87) in females who performed physical activity greater than or equal to two times per week but not every day; they were 0.82 (0.76‐0.89) in males and 1.01 (0.95‐1.07) in females who performed physical activity every day. Conclusions Regular physical activity could reduce the risk of incident dementia in older Japanese adults, except females who performed physical activity every day.

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“…These criteria remained unchanged throughout the follow‐up period. In previous studies, the Dementia Scale of LTCI certification has been shown to correlate well with Hasegawa's Dementia Scale and the Mini‐Mental State Examination Scale, and has been applied as a measurement of incident dementia in older adults in Japan . We obtained LTCI information from the Okayama City Public Health Center under privacy protection.…”

Section: Methodsmentioning

confidence: 99%

Alcohol consumption and incident dementia in older Japanese adults: The Okayama Study

Liu

Mitsuhashi

Yamakawa

et al. 2019

Geriatrics Gerontology Int

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Aim To evaluate the association between the amount and frequency of alcohol consumption and incident dementia in older Japanese adults using large sample size data over a long follow‐up period. Methods This was a retrospective cohort study carried out in Japan. A total of 53 311 older adults were followed from 2008 to 2014. A health checkup questionnaire was used to assess the amount and frequency of alcohol consumption. The Dementia Scale of long‐term care insurance was used as a measure of incident dementia. Cox proportional hazards models were used to calculate adjusted hazard ratios, with their 95% confidence intervals, for the incidence of dementia across the categories of alcohol consumption by sex. Results During a 7‐year follow‐up period, 14 479 participants were regarded as having incident dementia. Compared with non‐drinkers, the multivariate adjusted hazard ratios for participants with alcohol consumption ≤2 units per day, occasionally (0.88, 95% CI 0.81–0.96 in men and 0.84, 95% 0.79–0.90 in women) and daily (0.79, 95% 0.73–0.85 in men and 0.87, 95% 0.78–0.97 in women) were statistically significant, and the difference between occasional and daily consumption was only statistically significant in men; however, for participants with alcohol consumption >2 units per day, occasionally (0.91, 95% 0.71–1.16 in men and 1.09, 95% 0.72–1.67 in women) and daily (0.89, 95% 0.81–1.00 in men and 1.16, 95% 0.84–1.81 in women) were not significant. Conclusions Alcohol consumption of ≤2 units per day, occasionally or daily, could reduce the risk of incident dementia, with greater benefit for men with such daily consumption. Geriatr Gerontol Int 2019; 19: 740–746.

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Mushroom Consumption and Incident Dementia in Elderly Japanese: The Ohsaki Cohort 2006 Study

Abstract: This cohort study suggests that frequent mushroom consumption is significantly associated with a lower risk of incident dementia, even after adjustment for possible confounding factors.

Cited by 48 publications

References 48 publications

Ergothioneine – a diet‐derived antioxidant with therapeutic potential

Ergothioneine – a diet‐derived antioxidant with therapeutic potential

Physical activity and incident dementia in older Japanese adults: The Okayama study

Alcohol consumption and incident dementia in older Japanese adults: The Okayama Study

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