Mushroom‐Derived Products as an Alternative Antimalarial Therapeutics: A Review

Mkhize, Senzosenkosi Surprise; Machaba, Kgothatso E; Simelane, Mthokozisi B. C.; Pooe, Ofentse Jacob

doi:10.1002/9783527830589.ch10

Drug Development for Malaria 2022

DOI: 10.1002/9783527830589.ch10

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Mushroom‐Derived Products as an Alternative Antimalarial Therapeutics: A Review

Senzosenkosi Surprise Mkhize

Kgothatso E Machaba

Mthokozisi B. C. Simelane

et al.

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2023

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Anti-Toxoplasma gondii activity of Trametes versicolor (Turkey tail) mushroom extract

Sharma,

Catrett,

Nwokeocha

et al. 2023

Sci Rep

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Toxoplasma gondii (T. gondii) infection continues to rise globally in humans and animals with high socioeconomic and public health challenges. Current medications used against T. gondii infection are limited in efficacy, safety, and affordability. This research was conducted to assess the higher fungi extract effect on T. gondii tachyzoites growth in vitro and possibly decipher its mechanism of action. Furthermore, we evaluated the extract's effect on human foreskin fibroblast viability. The methanol extracts of Turkey tail (TT) mushroom was tested against T. gondii tachyzoites growth using an RH-RFP type I strain that expresses red fluorescent protein throughout culture in a dose-dependent manner using a fluorescent plate reader. Similarly, we tested the effect of the extract on host cell viability. We observed that TT extract inhibited tachyzoites growth with a 50% minimum inhibitory concentration (IC50s), IC50 = 5.98 ± 1.22 µg/mL, and 50% cytotoxic concentration (CC50s), CC50 ≥ 100 µg/mL. It was discovered that TT extract induced strong mitochondria superoxide and reactive oxygen species production and disrupted mitochondria membrane potential in T. gondii tachyzoites. Additionally, scanning electron microscopy depicted that TT extract and pyrimethamine (PY) caused a morphological deformation of tachyzoites in vitro. In conclusion, TT methanol extract made up of phytosterols, bioactive sphingolipids, peptides, phenolic acids, and lactones could be a promising source of new compounds for the future development of anti-Toxoplasma gondii drugs. Extracts were non-cytotoxic, even at higher concentrations.

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Anti-Toxoplasma gondii activity of Trametes versicolor (Turkey tail) mushroom extract

Sharma,

Catrett,

Nwokeocha

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

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Mushroom‐Derived Products as an Alternative Antimalarial Therapeutics: A Review

Cited by 1 publication

References 66 publications

Anti-Toxoplasma gondii activity of Trametes versicolor (Turkey tail) mushroom extract

Anti-Toxoplasma gondii activity of Trametes versicolor (Turkey tail) mushroom extract

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