Mushrooms: A Pandora Box of Cardioprotective Phytochemicals

Shibu, Marthandam Asokan; Agrawal, D. C.; Huang, Chih‐Yang

doi:10.1007/978-981-10-5978-0_11

Cited by 12 publications

(12 citation statements)

References 126 publications

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“…Generally, mushroom species contain from 3 to 15 phenolic compounds, and gallic, and protocatechuic acids are the most commonly reported [18]. All pohenolics are used as indicators of the antioxidant capacity, which is linked to their hydroxyl groups [19]. Gallic acid is known to activate diverse pharmacological and biochemical effects in humans including strong anti-cancer, antioxidant, and anti-inflammatory factors [20].…”

Section: Introductionmentioning

confidence: 99%

Selenium and Zinc Biofortification of Pleurotus eryngii Mycelium and Fruiting Bodies as a Tool for Controlling Their Biological Activity

et al. 2020

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Pleurotus eryngii (DC:Fr.) Quel. is a cultivated mushroom of high culinary value and medicinal properties. Mycelium of P. eryngii is characterized by the ability of effective bio-elements absorption from growth media so it could be biofortified with trace elements with a functional activity in the human body. In this study, the ability of P. eryngii mycelia from in vitro cultures as well as fruiting bodies were investigated in terms of their effectiveness in zinc and selenium accumulation. The effect of Se and Zn biofortification on productivity, chemical compounds, and bio-elements content of P. eryngii was determined as well. To enhance Se and Zn content in P. eryngii fruiting bodies and mycelia, substrates were supplemented with sodium selenite, at a concentration of 50 mg L−1, zinc sulfate, and zinc hydro-aspartate at a concentration of 87.2 and 100.0 mg L−1, respectively. Mentioned Zn concentrations contained the same amount of zinc(II) ions, namely 20 mg L−1. The content of organic compounds include phenolic compounds and lovastatin, which were determined by a high-performance liquid chromatography with diode-array detector (HPLC-DAD) and reverse phase high-performance liquid chromatography (RP-HPLC) method with UV detection. The ability of P. eryngii to accumulate zinc and selenium from the culture medium was demonstrated. The degree of accumulation of zinc turned out to be different depending on the type of salt used. The present study also showed that conducting mycelium of P. eryngii in in vitro culture, with a higher content of zinc ions, can result in obtaining the materials with better antioxidant ability. The results of this study can be used to develop the composition of growing media, which ensures the production of biomass with the desired composition of elements.

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Section: Introductionmentioning

confidence: 99%

Selenium and Zinc Biofortification of Pleurotus eryngii Mycelium and Fruiting Bodies as a Tool for Controlling Their Biological Activity

et al. 2020

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“…Our previous results show that food ingredients and phytochemicals exhibit various diverse biological activities [37][38][39][40][41]. Particularly various phytoextracts and their active principles have shown to provide effective cardioprotection against various challenges [42][43][44][45][46][47][48][49][50]. Cocoa consumption has been previously linked to cardiac health and various mechanisms have been proposed for the cardioprotective effects of cocoa [51].…”

Section: Discussionmentioning

confidence: 99%

Tetramethylpyrazine reverses high-glucose induced hypoxic effects by negatively regulating HIF-1α induced BNIP3 expression to ameliorate H9c2 cardiomyoblast apoptosis

et al. 2020

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Background: Diabetic patients are highly vulnerable to hypoxic injury, which is associated with hypoxia induced BNIP3 expression that subsequently activate apoptosis. Our previous research show that Tetramethylpyrazine (TMP), a food flavoring agent, represses the hypoxia induced BNIP3 expression attenuate myocardial apoptosis. In this study, we evaluate the effect of TMP to provide protection against hypoxia aggravated high-glucose associated cellular apoptosis. Methods: The cytoprotective effect of TMP against high glucose induced cellular damages was determined on embryo derived H9c2 cardiomyoblast cells that were subjected to 5% hypoxia for 24 h and subjected to different duration of 33 mM high glucose challenge. Further, the involvement of HIF-1α and BNIP3 in cellular damage and the mechanism of protection of TMP were determined by overexpression and silencing HIF-1α and BNIP3 protein expression. Results: The results show that hypoxic effects on cell viability aggravates with high glucose challenge and this augmentative effect is mediated through BNIP3 in H9c2 cardiomyoblast cells. However, TMP administration effectively reversed the augmented HIF-1α levels and BNIP3 elevation. TMP improved the survival of H9c2 cells and effectively suppressed apoptosis in H9c2 cells. Further comparison on the effects of TMP on H9c2 cells challenged with high glucose and those challenged with hypoxia show that TMP precisely regulated the hypoxic intensified apoptotic effects in high-glucose condition. Conclusion: The results clearly show that flavoring agent-TMP attenuates cytotoxicity amplified by hypoxia challenge in high glucose condition by destabilizing HIF-1α.

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“…Various alternative approaches have been demonstrated to deliver cardioprotective effects against numerous pathological conditions [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] . According to American College of Sports Medicine and the American Heart Association exercise training provide cardiacprotection in conditions like hypertension, coronary artery disease and it is also widely known to attenuate ischemia-reperfusion injury in aged adults [38] , [39] .…”

Section: Discussionmentioning

confidence: 99%

Exercise training restores IGFIR survival signaling in d-galactose induced-aging rats to suppress cardiac apoptosis

Lay

Kuo

Shibu

et al. 2021

Journal of Advanced Research

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Mushrooms: A Pandora Box of Cardioprotective Phytochemicals

Cited by 12 publications

References 126 publications

Selenium and Zinc Biofortification of Pleurotus eryngii Mycelium and Fruiting Bodies as a Tool for Controlling Their Biological Activity

Selenium and Zinc Biofortification of Pleurotus eryngii Mycelium and Fruiting Bodies as a Tool for Controlling Their Biological Activity

Tetramethylpyrazine reverses high-glucose induced hypoxic effects by negatively regulating HIF-1α induced BNIP3 expression to ameliorate H9c2 cardiomyoblast apoptosis

Exercise training restores IGFIR survival signaling in d-galactose induced-aging rats to suppress cardiac apoptosis

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