Society needs transdisciplinary citizens with good scientific literacy. One way to achieve this could be through the use of areas or subjects for which students have more affinity and expertise. This study seeks to maximize the chemistry learning of students who want to be musicians, through the use of analogies. Analogies are a powerful tool to explain abstract, unfamiliar, or complex scientific concepts (such as the quantum atomic model) in familiar terms and to promote positive attitudes toward learning science. A case study is presented regarding the use of musical analogies developed to teach the atom concept, subatomic particles, and the atomic structure, according to the quantum mechanical model of the atom. A cohort of 50 Portuguese 12 to 13 year old students, enrolled in the seventh grade of a middle school music course, was selected by convenience sampling from four schools. A questionnaire and interviews were used for data gathering. The results show that the musical analogies used helped to overcome students' difficulties regarding the topics taught, improved chemistry learning, and stimulated attentiveness and interest. The use of analogies between music and chemistry with students of similar characteristics to those of this study, or the use of different areas and subjects for other student backgrounds and tastes, can be fruitful for teaching chemical content.