MuSK myasthenia gravis and Lambert–Eaton myasthenic syndrome in the same patient

Basta, Ivana; Nikolić, Aleksandra; Losen, Mario; Martínez‐Martínez, Pilar; Stojanović, Vidosava Rakočević; Lavrnić, Slobodan; Baets, Marc De; Lavrnić, Dragana

doi:10.1016/j.clineuro.2011.12.044

Cited by 11 publications

(11 citation statements)

References 5 publications

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“…Data from our review do not allow any firm conclusion, as one SCLC was associated with overlap syndrome (with MuSK and VGCC Abs) [26]. The other four SCLCs [15,18,28] were found in patients, in whom VGCC Abs were not tested.…”

Section: Discussionmentioning

confidence: 90%

Myasthenia gravis with presynaptic neurophysiological signs: Two case reports and literature review

Alboini

Damato

Iorio

et al. 2015

Neuromuscular Disorders

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Section: Discussionmentioning

confidence: 90%

Myasthenia gravis with presynaptic neurophysiological signs: Two case reports and literature review

Alboini

Damato

Iorio

et al. 2015

Neuromuscular Disorders

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“…However, many cases have been reported to support the coexistence or overlap of the 2 diseases. [ 1 – 3 ] The incidence of the 2 diseases is not high. According to the report, [ 5 ] the incidence of MG ranges between 9 and 30 out of 1 million and the prevalence ranges from 100 to 140 out of 1 million.…”

Section: Discussionmentioning

confidence: 99%

“…[ 5 ] The cases which coexist of the 2 diseases at the same time is rather rare, mostly in the form of case reports. [ 1 – 3 , 7 ] MG coexisting LEMS with SCLC is even rarer. Of the 55 MLOS patients Oh et al [ 4 ] reviewed, there were only 7 patients with SCLC.…”

Section: Discussionmentioning

confidence: 99%

“…Although there has been controversial about the coexistence of MG and LEMS in the same patient, several case reports in the past years described the rare association of LEMS and MG. [ 1 – 3 ] Oh [ 4 ] reviewed 55 possible cases of the myasthenia gravis Lambert–Eaton overlap syndrome (MLOS) and discussed the various issues related to MLOS, finally thought that MLOS does exist.…”

Section: Introductionmentioning

confidence: 99%

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Coexistence of myasthenia gravis and Lambert–Eaton myasthenic syndrome in a small cell lung cancer patient

Rui¹,

Chen²,

Ge³

et al. 2018

Medicine

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Rationale:Myasthenia gravis (MG) and Lambert–Eaton myasthenic syndrome (LEMS) are both neuromuscular junction diseases, and some controversy exists whether the 2 diseases occur at the same time.Patient concerns:We report a case that a patient with presentation of acetylcholine receptor (AChR) antibody positive MG and LEMS associated with small cell lung cancer (SCLC).Diagnoses:The patient firstly suffered from fluctuant symptoms, including slurred speech, double eyelid ptosis, and weakness of limbs. His clinical characteristics were consistent with the diagnosis of MG and were effective with the treatment of pyridostigmine bromide and corticosteroids. After 8 months, the performance of repeated electrical stimulation suggested presynaptic lesion, which supported the patient with LEMS. After further examination, malignant tumors were found in the liver and right lung, and the pathology proved small cell carcinoma.Interventions:His clinical characteristics were effective with the treatment of pyridostigmine bromide and corticosteroids. Right hilar lesion and multiple metastatic tumors in liver shrunk after chemotherapy.Outcomes:The patient's condition improved gradually. He was followed up for 17 months without tumor progression.Lessons:The case report illustrates that MG and LEMS may be coexisted in the same patient. In MG and LEMS, clinicians should consider the possibility of malignant tumors as early detection and treatment may significantly improve the patient's prognosis.

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“…2,3 In the literature, 26 patients with an MG and LEMS overlap syndrome have been reported. [4][5][6][7][8][9] Our patient is unique in that she fulfilled all the diagnostic criteria of seronegative MG initially and all the diagnostic criteria of seropositive LEMS 20 years later. A similar scenario was reported in another case in which AChR-ab and VGCC-ab were positive.…”

Section: A Patient Diagnosed With Mg At Onset and Lems 20 Years Latermentioning

confidence: 99%

A patient diagnosed with Mg at onset and Lems 20 years later

et al. 2013

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MuSK myasthenia gravis and Lambert–Eaton myasthenic syndrome in the same patient

Cited by 11 publications

References 5 publications

Myasthenia gravis with presynaptic neurophysiological signs: Two case reports and literature review

Myasthenia gravis with presynaptic neurophysiological signs: Two case reports and literature review

Coexistence of myasthenia gravis and Lambert–Eaton myasthenic syndrome in a small cell lung cancer patient

A patient diagnosed with Mg at onset and Lems 20 years later

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