Mussel-inspired hydrogels for biomedical and environmental applications

Lin, L.; Smitthipong, Wirasak; Zeng, Hongbo

doi:10.1039/c4py01415d

Cited by 187 publications

(150 citation statements)

References 44 publications

Supporting

Mentioning

149

Contrasting

Unclassified

Order By: Relevance

“…This is especially important in the case of the mussel owing to its sessile lifestyle and cosmopolitan distribution. From a broader perspective, the current findings are relevant for the growing field of mussel-inspired materials based on DOPA chemistry [39,47] and suggest that a fixed scaffold of cross-linking sites may be a critical design consideration for synthesizing hard and extensible materials for coating applications.…”

Section: Resultsmentioning

confidence: 99%

Mechanical homeostasis of a DOPA-enriched biological coating from mussels in response to metal variation

Schmitt

Winter

Bertinetti

et al. 2015

J. R. Soc. Interface.

View full text Add to dashboard Cite

Protein -metal coordination interactions were recently found to function as crucial mechanical cross-links in certain biological materials. Mussels, for example, use Fe ions from the local environment coordinated to DOPA-rich proteins to stiffen the protective cuticle of their anchoring byssal attachment threads. Bioavailability of metal ions in ocean habitats varies significantly owing to natural and anthropogenic inputs on both short and geological spatio-temporal scales leading to large variations in byssal thread metal composition; however, it is not clear how or if this affects thread performance. Here, we demonstrate that in natural environments mussels can opportunistically replace Fe ions in the DOPA coordination complex with V and Al. In vitro removal of the native DOPA-metal complexes with ethylenediaminetetraacetic acid and replacement with either Fe or V does not lead to statistically significant changes in cuticle performance, indicating that each metal ion is equally sufficient as a DOPA cross-linking agent, able to account for nearly 85% of the stiffness and hardness of the material. Notably, replacement with Al ions also leads to full recovery of stiffness, but only 82% recovery of hardness. These findings have important implications for the adaptability of this biological material in a dynamically changing and unpredictable habitat.

show abstract

Section: Resultsmentioning

confidence: 99%

Mechanical homeostasis of a DOPA-enriched biological coating from mussels in response to metal variation

Schmitt

Winter

Bertinetti

et al. 2015

J. R. Soc. Interface.

View full text Add to dashboard Cite

show abstract

“…25 In this design, the hydrogel building material PEG was modified with reactive catechol moieties to mimic the function of mussel adhesive proteins, in which the amino acid 3,4-dihydroxyphenylalanine (DOPA) that contains catechol played a critical role in enabling the mussel to adhere to various surfaces in an aqueous environment. 55 In the study, silver nitrate (AgNO 3 , 212 mM) was used to oxidize catechol gel (Ag:catechol = 2:1 mol/mol), leading to covalent cross-linking and hydrogel formation with simultaneous reduction of Ag(I). Silver release was sustained for a period of at least two weeks in biological buffer solutions.…”

Section: Site-specific Drug Deliverymentioning

confidence: 99%

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

et al. 2016

View full text Add to dashboard Cite

Nanoparticles have offered a unique set of properties for drug delivery including high drug loading capacity, combinatorial delivery, controlled and sustained drug release, prolonged stability and lifetime, and targeted delivery. To further enhance therapeutic index, especially for localized application, nanoparticles have been increasingly combined with hydrogels to form a hybrid biomaterial system for controlled drug delivery. Herein, we review recent progresses in engineering such nanoparticle-hydrogel hybrid system (namely ‘NP-gel’) with a particular focus on its application for localized drug delivery. Specifically, we highlight four research areas where NP-gel has shown great promises, including (1) passively controlled drug release, (2) stimuli-responsive drug delivery, (3) site-specific drug delivery, and (4) detoxification. Overall, integrating therapeutic nanoparticles with hydrogel technologies creates a unique and robust hybrid biomaterial system that enables effective localized drug delivery.

show abstract

“…3,4-Dihydroxy-phenylalanine (DOPA) residues, which are modified amino acids, have catecholic functionality and can be found in UMAPs. The catechol groups of dopamine can strongly interact with a variety of organic/inorganic substrates via coordination, covalent bonds, π-π stacking, electrostatic forces, and hydrogen bonding, which allows mussels to attach to various surfaces such as glass, plastic, wood and metals in an aqueous environment [11][12][13][14][15][16][17]. In 1981, Waite and Tanzer determined that catechols were responsible for the adhesion of mussels in inhospitable regions under very harsh and wet conditions [18].…”

Section: Introductionmentioning

confidence: 99%

“…Marine mussels (mytilus edulis), such as the blue mussel, attach to a variety of surfaces in aqueous environments through the use of a natural adhesive that is incredibly strong and can form durable bonds to glass, plastic, wood, concrete, and Teflon [1,[7][8][9]]. Marine mussels withstand high-energy wave impacts in rocky seashore habitats by fastening tightly to surfaces with tough and self-healing proteinaceous fibers, called byssal threads, composed of 25-30 different types of underwater mussel adhesive proteins (UMAPs) [10][11][12][13]. 3,4-Dihydroxy-phenylalanine (DOPA) residues, which are modified amino acids, have catecholic functionality and can be found in UMAPs.…”

Section: Introductionmentioning

confidence: 99%

Bioinspired dopamine-conjugated polyaspartamide as a novel and versatile adhesive material

Wang¹,

Jeon²,

Bhang³

et al. 2017

Express Polym. Lett.

View full text Add to dashboard Cite

Abstract. Biomimetic dopamine-conjugated polyaspartamides as novel adhesive materials were synthesized and characterized. These modified polyaspartamides contain three different groups combined with dopamine (DOPA), i.e., γ-amino butyric acid (GABA), ethanolamine (EA) and octylamine (OA), which are referred to as PolyAspAm (DOPA/GABA), PolyAspAm(DOPA/EA) and PolyAspAm(DOPA/OA), respectively. These three water-swollen polymer glues show good adhesion (0.1~0.4 MPa) with various daily-life materials (aluminum foil, glass and paper) as well as some plastic substrates (PET and PMMA). Compared to the polymers with more hydrophilic groups (GABA and EA), the polymer glue with the hydrophobic alkyl group (OA) exhibited higher adhesive strength values on most substrates. In addition, when applied to biological porcine skin, these glues demonstrated adhesion of values of 15~20 kPa with EA-and OA-conjugated polymers. These results suggest the great potential of dopamine-modified polyaspartamides as versatile and efficient polymeric glues for industrial and biomedical applications.

show abstract

Mussel-inspired hydrogels for biomedical and environmental applications

Abstract: This mini-review highlights the recent development of mussel-inspired hydrogels in biomedical and environmental fields.

Cited by 187 publications

References 44 publications

Mechanical homeostasis of a DOPA-enriched biological coating from mussels in response to metal variation

Mechanical homeostasis of a DOPA-enriched biological coating from mussels in response to metal variation

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

Bioinspired dopamine-conjugated polyaspartamide as a novel and versatile adhesive material

Contact Info

Product

Resources

About