Mussel-Inspired Multicomponent Codeposition Strategy toward Antibacterial and Lubricating Multifunctional Coatings on Bioimplants

Abstract

Bacterial infections and limited surface lubrication are the two key challenges for bioimplants in dynamic contact with tissues. However, the simultaneous lubricating and antibacterial properties of the bioimplants have rarely been investigated. In this work, we successfully developed a multifunctional coating with simultaneous antibacterial and lubricating properties for surface functionalization of bioimplant materials. The multifunctional coating was fabricated on a polyurethane (PU) substrate via polydopamine (PDA)-assisted multicomponent codeposition, containing polyethyleneimine (PEI) and trace amounts of copper (Cu) as synergistic antibacterial components and zwitterionic poly­(2-methacryloyloxyethyl phosphorylcholine) (PMPC) as the lubricating component. The obtained PDA­(Cu)/PEI/PMPC coating showed excellent antibacterial activity (antibacterial efficiency: ∼99%) to both Escherichia coli and Staphylococcus aureus compared with bare PU. The excellent antibacterial properties were attributed to the combined effect of anti-adhesion capability of hydrophilic PMPC and PEI and bactericidal activity of Cu in the coating. Meanwhile, the coefficient of friction of the coating was significantly decreased by ∼52% compared with bare PU owing to the high hydration feature of PMPC, suggesting the superior lubricating property. Furthermore, the PDA­(Cu)/PEI/PMPC coating was highly biocompatible toward human umbilical vein endothelial cells demonstrated by in vitro cytotoxicity tests. This study not only contributes to the chemistry of PDA-assisted multicomponent codeposition but also provides a facile and practical way for rational design of multifunctional coatings for medical devices.

Recent nanotechnology-based strategies for interfering with the life cycle of bacterial biofilms

“…Additionally, the physical antiadhesive ability can also be integrated into bactericidal surfaces to maximize the inhibition of biofilm formation. 62,63…”

Phenolic-Compound-Based Functional Coatings: Versatile Surface Chemistry and Biomedical Applications

“…For example, Zhang et al used a PDA coating as the intermediate layer to introduce PEI via the Schiff-base or Michael addition reaction, followed by ring-opening reaction to introduce zwitterionic poly(2-methacryloyloxyethyl phosphorylcholine-co-glycidyl methacrylate) [poly(MPC-co-GMA)] for designing a natural lubrication and antibacterial coating on bioimplants. 22 On the other hand, surface grafting of polymer brushes via atom transfer radical polymerization (ATRP) is a promising pathway to further modify polyphenol-based coatings. 23 The optical property of polyphenol-based coatings is an interesting aspect to discuss.…”

“…The modification of polyphenols with other molecules and polymers via covalent conjugation allows the polyphenol-coated surfaces to act as the intermediating layer for the introduction of additional polymer-based functional coatings. For example, Zhang et al used a PDA coating as the intermediate layer to introduce PEI via the Schiff-base or Michael addition reaction, followed by ring-opening reaction to introduce zwitterionic poly­(2-methacryloyloxyethyl phosphorylcholine- co -glycidyl methacrylate) [poly­(MPC- co -GMA)] for designing a natural lubrication and antibacterial coating on bioimplants . On the other hand, surface grafting of polymer brushes via atom transfer radical polymerization (ATRP) is a promising pathway to further modify polyphenol-based coatings .…”

Bioinspired Polycation Functionalization of the Polyurethane Surface for Enhanced Lubrication, Antibacterial Property, and Anticoagulation

“…Consequently, the excellent antibacterial performance of PU-PDA/PEI-PMPC samples is a combination of the anti-adhesive behavior of PMPC and the bactericidal ability of PEI. 27,39 3.6. Hemocompatibility of the Polymer Coating on the PU Substrate.…”

“…So far, several modification methods have been applied to modify PEI on the surface of biomaterials, but the functionalization process is very complicated. Dopamine has a unique advantage in assisting PEI deposition by forming the covalent bonds with PEI via Michael addition or Schiff base reactions. − Although dopamine-assisted deposition of PEI and zwitterionic polymers has been adopted in some works, its application is relatively limited, and PEI and zwitterionic polymer are comparatively independent. In this case, the synthesis of PEI and zwitterionic polymer compound may endow a biomaterial surface with improved antibacterial and contact-killing properties as well as lubrication and anticoagulant performances.…”