Recent nanotechnology-based strategies for interfering with the life cycle of bacterial biofilms

Wu, Jiahe; Zhang, Bo; Lin, Nengming

doi:10.1039/d2bm01783k

Cited by 10 publications

(5 citation statements)

References 189 publications

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“…Meanwhile, nanotechnology strategies that can interfere with the biofilm formation (a major factor in bacterial resistance development against antibiotics) are reported to be the most effective approach [ 37 ]. Overcoming antibiotic resistance, especially due to biofilms, is a crucial factor for overcoming the challenges of antibiotic resistance in general.…”

Section: Viewpoint and Discussion With Conclusionmentioning

confidence: 99%

“…Lipid-based nanoparticles Targeted delivery of antibiotics to combat bacterial resistance [29] Metal-based nanoparticles Enhancing the efficacy of antimicrobial agents against resistant pathogens [30] Polymeric nanoparticles Overcoming multidrug resistance in cancer cells through combination therapy [31] Mesoporous silica nanoparticles Controlled release of antimicrobial agents to overcome resistance in bacteria [32] Quantum dots Imaging and monitoring drug-resistant cancer cells for personalized medicine [33] Dendrimers Delivery of gene-silencing agents to combat drug resistance in viral infections [34] Nanoemulsions Targeted delivery of antimicrobial agents against resistant pathogens [35] Gold nanoparticles Overcoming multidrug resistance in chemotherapy [36] Meanwhile, nanotechnology strategies that can interfere with the biofilm formation (a major factor in bacterial resistance development against antibiotics) are reported to be the most effective approach [37]. Overcoming antibiotic resistance, especially due to biofilms, is a crucial factor for overcoming the challenges of antibiotic resistance in general.…”

Section: Nanomaterials Applications Referencesmentioning

confidence: 99%

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Nanotechnology—A Light of Hope for Combating Antibiotic Resistance

Muteeb

2023

Microorganisms

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Antibiotic usage and resistance are major health concerns. Antibiotic resistance occurs when bacteria evolve to resist the effects of antibiotics, making it impossible to treat infections. The overuse and misuse of antibiotics are the main contributing factors, while environmental stress (such as heavy metals accumulation), unhygienic conditions, illiteracy, and unawareness also contribute to antibiotic resistance. The slow and costly development of new antibiotics has lagged behind the emergence of antibiotic-resistant bacteria, and the overuse of antibiotics leads to negative consequences. The current study used different literature resources to generate an opinion and find a possible solution to antibiotic barriers. Different scientific approaches have been reported to overcome antibiotic resistance. The most useful approach among these is nanotechnology. Nanoparticles can be engineered to disrupt bacterial cell walls or membranes, effectively eliminating resistant strains. Additionally, nanoscale devices enable the real-time monitoring of bacterial populations, allowing for the early detection of resistance emergence. Nanotechnology, along with evolutionary theory offers promising avenues in combating antibiotic resistance. Evolutionary theory helps us understand the mechanisms by which bacteria develop resistance, allowing us to anticipate and counteract their adaptive strategies. By studying the selective pressures that drive resistance, we can therefore design more effective interventions or traps. The synergy between the evolutionary theory and nanotechnology presents a powerful approach to combat antibiotic resistance, offering new avenues for the development of effective treatments and the preservation of our antibiotic arsenal.

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Section: Viewpoint and Discussion With Conclusionmentioning

confidence: 99%

Section: Nanomaterials Applications Referencesmentioning

confidence: 99%

Nanotechnology—A Light of Hope for Combating Antibiotic Resistance

Muteeb

2023

Microorganisms

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“…In infectious diseases, nanomedicine has applications in diagnosis as well as in therapy [13,38,[70][71][72][73]. More specifically, nanomedicine in the field of infectious diseases may aid in the diagnosis and treatment of bacterial, viral, parasitic, or mycobacterial disease [74][75][76][77][78][79]. The following sections of this review specifically address the applications of nanotechnology in diagnosing and treating infectious diseases.…”

Section: Principles Of Nanotechnologymentioning

confidence: 99%

Nanotechnology in the Diagnosis and Treatment of Antibiotic-Resistant Infections

Ioannou,

Baliou,

Samonis

2024

Antibiotics

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The development of antimicrobial resistance (AMR), along with the relative reduction in the production of new antimicrobials, significantly limits the therapeutic options in infectious diseases. Thus, novel treatments, especially in the current era, where AMR is increasing, are urgently needed. There are several ongoing studies on non-classical therapies for infectious diseases, such as bacteriophages, antimicrobial peptides, and nanotechnology, among others. Nanomaterials involve materials on the nanoscale that could be used in the diagnosis, treatment, and prevention of infectious diseases. This review provides an overview of the applications of nanotechnology in the diagnosis and treatment of infectious diseases from a clinician’s perspective, with a focus on pathogens with AMR. Applications of nanomaterials in diagnosis, by taking advantage of their electrochemical, optic, magnetic, and fluorescent properties, are described. Moreover, the potential of metallic or organic nanoparticles (NPs) in the treatment of infections is also addressed. Finally, the potential use of NPs in the development of safe and efficient vaccines is also reviewed. Further studies are needed to prove the safety and efficacy of NPs that would facilitate their approval by regulatory authorities for clinical use.

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“…Wu et al (2023) have reviewed latest nanotechnology-based approaches for impeding the growth cycle of biofilms. 15 The authors discussed the current nanotechnological approaches that cause interference with the bacterial biofilm formation at different stages and emphasized the significance of regulating the biofilm microenvironment. Further, a comprehensive review by Mohamad et al (2023) discusses the connection between biofilm formation and antimicrobial resistance and also explores novel methods for combating biofilms, such as CRISPR-Cas gene editing, natural compounds, phages, and nanomediated techniques.…”

Section: Introductionmentioning

confidence: 99%

“…Biomedical applications that have been widely employed include nanotechnology and nanomaterials, as they offer multiple advantages such as size, physicochemical characteristics, and potential to provide a maximum area–volume ratio. − Numerous review articles provide a comprehensive overview of various aspects of nanotechnology-based anti-biofilm strategies. Wu et al (2023) have reviewed latest nanotechnology-based approaches for impeding the growth cycle of biofilms . The authors discussed the current nanotechnological approaches that cause interference with the bacterial biofilm formation at different stages and emphasized the significance of regulating the biofilm microenvironment.…”

Section: Introductionmentioning

confidence: 99%

Advances in Nanotechnology for Biofilm Inhibition

et al. 2023

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Biofilm-associated infections have emerged as a significant public health challenge due to their persistent nature and increased resistance to conventional treatment methods. The indiscriminate usage of antibiotics has made us susceptible to a range of multidrug-resistant pathogens. These pathogens show reduced susceptibility to antibiotics and increased intracellular survival. However, current methods for treating biofilms, such as smart materials and targeted drug delivery systems, have not been found effective in preventing biofilm formation. To address this challenge, nanotechnology has provided innovative solutions for preventing and treating biofilm formation by clinically relevant pathogens. Recent advances in nanotechnological strategies, including metallic nanoparticles, functionalized metallic nanoparticles, dendrimers, polymeric nanoparticles, cyclodextrin-based delivery, solid lipid nanoparticles, polymer drug conjugates, and liposomes, may provide valuable technological solutions against infectious diseases. Therefore, it is imperative to conduct a comprehensive review to summarize the recent advancements and limitations of advanced nanotechnologies. The present Review encompasses a summary of infectious agents, the mechanisms that lead to biofilm formation, and the impact of pathogens on human health. In a nutshell, this Review offers a comprehensive survey of the advanced nanotechnological solutions for managing infections. A detailed presentation has been made as to how these strategies may improve biofilm control and prevent infections. The key objective of this Review is to summarize the mechanisms, applications, and prospects of advanced nanotechnologies to provide a better understanding of their impact on biofilm formation by clinically relevant pathogens.

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Recent nanotechnology-based strategies for interfering with the life cycle of bacterial biofilms

Abstract: Biofilm formation plays an important role in the resistance development of bacteria to conventional antibiotics. Different properties of the bacteria strains within the biofilm compared with their planktonic states and...

Cited by 10 publications

References 189 publications

Nanotechnology—A Light of Hope for Combating Antibiotic Resistance

Nanotechnology—A Light of Hope for Combating Antibiotic Resistance

Nanotechnology in the Diagnosis and Treatment of Antibiotic-Resistant Infections

Advances in Nanotechnology for Biofilm Inhibition

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