Mussel-inspired soft-tissue adhesive based on poly(diol citrate) with catechol functionality

Abstract

Marine mussels tightly adhering to various underwater surfaces inspires human to design adhesives for wet tissue adhesion in surgeries. Characterization of mussel adhesive plaques describes a matrix of proteins containing 3,4-dihydroxyphenylalanine (DOPA), which provides strong adhesion in aquatic conditions. Several synthetic polymer systems have been developed based on this DOPA chemistry. Herein, a citrate-based tissue adhesives (POEC-d) was prepared by a facile one-pot melt polycondensation of two diols including 1,8-octanediol and poly(ethylene oxide) (PEO), citric acid (CA) and dopamine, and the effects of hydrophilic and soft PEO on the properties of adhesives were studied. It was found that the obtained adhesives exhibited water-soluble when the mole ratio of PEO to 1,8-octanediol was 70%, and the equilibrium swelling percentage of cured adhesive was about 144%, and degradation rate was in the range of 1-2 weeks. The cured adhesives demonstrated soft rubber-like behavior. The lap shear adhesion strength measured by bonding wet pig skin was in the range of 21.7-33.7 kPa, which was higher than that of commercial fibrin glue (9-15 kPa). The cytotoxicity tests showed the POEC-d adhesives had a low cytotoxicity. Our results supports that POEC-d adhesives, which combined strong wet adhesion with good biodegradability, acceptable swelling ratio, good elasticity and low cytotoxicity, have potentials in surgeries where surgical tissue adhesives, sealants, and hemostatic agents are used.

Investigation of surgical adhesives for vocal fold wound closure

“…For Glubran 2, the average shear and tensile strength in the current study is around twice the value reported by Kull et al BioGlue's shear strength was found to be very similar to that reported by Sidle and Maas . For Tisseel, the average shear and tensile strength found in our study was approximately one order of magnitude greater than that from Kull et al’s study but falls within the range of values reported elsewhere . The differences in tissue substrate are deemed to be the main factor explaining the differences.…”

“…21 The reported average adhesive strength in the literature for Tisseel ranges between 0.7 kPa and 15 kPa. 19,[21][22][23] For Glubran 2, the average shear and tensile strength in the current study is around twice the value reported by Kull et al 19 BioGlue's shear strength was found to be very similar to that reported by Sidle and Maas. 20 For Tisseel, the average shear and tensile strength found in our study was approximately one order of magnitude greater than that from Kull et al's study 19 but falls within the range of values reported elsewhere.…”

“…They reported the adhesive shear strength of fibrin glue was 15.4 ± 2.8 kPa . The reported average adhesive strength in the literature for Tisseel ranges between 0.7 kPa and 15 kPa …”

Inhibition of Cariogenic Plaque Formation on Root Surface with Polydopamine-Induced-Polyethylene Glycol Coating

“…Polydopamine is used for biomaterial surface modification because it is easy to obtain abundant active groups. These active groups are mostly phenolic hydroxyl/o-quinone and amino/imino for bimolecular immobilization on the material surface with minimal change in the chemical structure of biomaterials [38]. The plausible mechanism of polydopamine-induced-PEG coating is shown in Figure 7.…”

“…( A ) methyl-polyethylene glycol (PEG)-amine unit; ( B ) Immobilization of selenocystamine via polydopamine linker [38]; ( C ) Interfacial location of aminated PEG, polydopamine and hydroxyapatite [15]. …”