Safety leadership, safe behavior, and safety climate, which are important parts of occupational safety culture, are important in terms of preventing occupational accidents and making the working environment ergonomic. In this context, this study aims to examine the mediating effect of the safety climate on the relationship between transformational leadership and safe behavior. Research was carried out with 287 participants working in two manufacturing plants, one from Turkey and one from Romania. The two data sets were consolidated into a single database (both companies being providers of manufacturing products for the same client in the automotive industry) and were analyzed using the Preacher and Hayes plugin in the SPSS 21 package program because of the research interest in investigating safety behavior in the manufacturing field. The results of the analysis showed that the safety climate had a partial mediating effect on the relationship between transformational leadership and safe behavior. In addition, the study results demonstrated that transformational safety leadership has a significant influence on employees’ perceptions of safety climate and plays an important role in occupational safety-related behaviors. Research results were helpful for practitioners (managers in both companies) and researchers in understanding the importance of safety-climate and transformational safety leadership practices in increasing occupational safety-related behaviors.