Mutagen-sensitive strain of mice

Aeschbacher, H.U.; Gootwick, D.; Meier, H.; Poot, A.W.

doi:10.1016/0027-5107(79)90169-6

Cited by 25 publications

(2 citation statements)

References 4 publications

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“…Conversely, the CD-1 mouse, which has the lowest negative control frequency and a frequency distribution profile skewed to the low end, appears to be one of the stocks least sensitive to clastogens. Two of the three comparisons involving CD-1 found it to be lowest in sensitivity [Aeschbacher et al, 1979;CSGMT, 1988;Sato et al, 19931. Although these data again seem to indicate an association between the negative control parameters and sensitivity to clastogens, more thorough studies are needed.…”

Section: Swiss Webstermentioning

confidence: 99%

“…To date, no study has thoroughly examined differences in the spontaneous frequencies among the many mouse stocks used with the assay. Several studies have attempted to compare the relative sensitivity of mouse stocks to clastogens [Aeschbacher et al, 1979;Aeschbacher 1986;Hayashi et al, 1982;Styles et al, 1983;Sat0 et al, 1987Sat0 et al, , 1990Sat0 et al, , 1993 The Collaborative Study Group (CSGMT), 19881. The problem with the approach used in these studies is that it is difficult to put together a study that incorporates enough different mouse stocks and participating test facilities, along with a sufficient number and variety of chemicals, to come to a definitive conclusion.…”

Section: Introductionmentioning

confidence: 99%

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Bone marrow micronucleus assay: A review of the mouse stocks used and their published mean spontaneous micronucleus frequencies

Salamone

Mavournin

1994

Environ and Mol Mutagen

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We have examined published negative control data from 581 papers on micronucleated bone marrow polychromatic erythrocytes (mnPCE) for differences in mean frequency and the frequency distribution profile among the mouse stocks used with the bone marrow micronucleus assay. For the 55 mouse stocks with published micronucleus assay data, the overall mean frequency is 1.95 mnPCE/1,000 PCE (1.95 mnPCE/1,000); for the 13 stocks most commonly used in the assay, it is 1.88 mnPCE/1,000. During the last 5 years, the mnPCE rate for these 13 major stocks has been 1.74 mnPCE/1,000. This current mean frequency is a substantial decrease from the mean of 3.07 mnPCE/1,000 observed for these 13 stocks for data published prior to 1981. Of the major stocks, the highest mean mnPCE negative control frequencies were observed for MS/Ae > BALB/c > C57Bl/6, and the lowest for CD-1 < Swiss Webster. We note that hybrid mouse stocks appear to have lower and less variable negative control frequencies than either of their parent strains and that the negative control frequency for some progeny stocks have diverged significantly from that of the parent stocks. Overall mean negative control frequencies appear to be correlated with breadth of the frequency distribution profile of published mean negative control values. Furthermore, a possible correlation between negative control frequency in the micronucleus assay and sensitivity to clastogens of different mouse strains may be indicated. The databases generated here allow us to define a range of norms for both the historical mean frequency and individual experimental mean frequencies for most stocks, but in particular, for the more commonly used mouse stocks. Our analysis, for the most part, bears out the recommendation of the first Gene-Tox Report on the micronucleus assay that the historical negative control frequency for a mouse stock should fall between 1 and 3 mnPCE/1,000. Eighty-six percent of the most commonly used mouse stocks have historical mean frequencies within this range. Though individual experimental mean values would not necessarily be expected to fall within the 1-3.00 mnPCE/1,000 range, 65.3% of the 2,327 published negative control values do, and 83.5% are < 3 mnPCE/1,000. The frequency with which an individual experimental mean value lies outside the 1.00 to 3.00 mnPCE/1,000 range differs among stocks and appears related to the mouse mean frequency. We suggest that the recommended range for historical mean frequency be extended slightly, to approximately 3.4 mnPCE/1,000, to accommodate some commonly used strains with overall mean negative control frequencies just above 3.00 mnPCE/1,000.(ABSTRACT TRUNCATED AT 400 WORDS)

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Section: Swiss Webstermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bone marrow micronucleus assay: A review of the mouse stocks used and their published mean spontaneous micronucleus frequencies

Salamone

Mavournin

1994

Environ and Mol Mutagen

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Entire nucleotide sequence of mitochondrial DNA of MS/Ae mice

Sutou

1996

Environ. Mol. Mutagen.

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Maternal effect on micronucleus induction in MS/Ae mice

Sutou

Sato

1990

Environ and Mol Mutagen

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MS/Ae mice, which are mutagen-sensitive in both the dominant lethal test and micronucleus test, and CD-1 mice, which are the parental strain of MS/Ae, were mated in all four possible combinations. Both male and female offspring were subjected to the micronucleus test using mitomycin C (MMC), colchicine (Col), and 6-mercaptopurine (6-MP). Col showed equivocal results. However, MMC and 6-MP showed differential responses in that both male and female offspring from CD-1 dams had lower incidences of micronucleated polychromatic erythrocytes than those from MS/Ae dams regardless of sire strain. In addition, body weights of offspring from MS/Ae dams were lower than those from CD-1 dams regardless of sire strain. Numbers of offspring from MS/Ae dams tended to be smaller than those from CD dams. These results suggest that the traits of MS/Ae mice are associated more with maternal factors than with paternal ones.

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Mutagen-sensitive strain of mice

Cited by 25 publications

References 4 publications

Bone marrow micronucleus assay: A review of the mouse stocks used and their published mean spontaneous micronucleus frequencies

Bone marrow micronucleus assay: A review of the mouse stocks used and their published mean spontaneous micronucleus frequencies

Entire nucleotide sequence of mitochondrial DNA of MS/Ae mice

Maternal effect on micronucleus induction in MS/Ae mice

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