Mutagenic activities of gentisin and isogentisin from Gentianae radix (Gentianaceae)

Morimoto, Isao; Nozaka, Tomio; Watanabe, Fujio; Ishino, Masazo; Hirose, Yoichi; Okitsu, Tomoaki

doi:10.1016/0165-1218(83)90101-5

Cited by 31 publications

(9 citation statements)

References 11 publications

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“…Some of them, listed in Table 2.1, showed mutagenic effects after metabolic activation in certain S. typhimurium strains. The corresponding glycosides were inactive when ␤-glucosidase was absent in the system (Morimoto et al, 1983;Kanamori et al, 1984;Matsushima et al, 1985).…”

Section: Other Endogenous Mutagens In Plantsmentioning

confidence: 99%

Molecular Modes of Action of Defensive Secondary Metabolites

Wink

Schimmer

2010

Functions and Biotechnology of Plant Secondary Metabolites

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Secondary metabolites (SM) have been shaped by evolution for more than 500 million years. As a result, many of them have distinctive biochemical and pharmacological properties. The molecular modes of action of the main groups of SM are reviewed in this chapter. Details are given on interactions of SM with proteins that can induce conformational changes and thus a modification of their bioactivity. The fluidity and permeability of biomembranes constitute another important target, which is influenced by many lipophilic and amphiphilic SM. A number of SM can either alkylate or intercalate DNA, which can cause mutations and in consequence cancer or malformations. Many SM are cytotoxic because they interfere with biomembranes, proteins of the cytoskeleton or DNA; they often induce programmed cell death (apoptosis). A large number of SM, especially alkaloids modulate neuronal signal transduction by interfering with ion channels, ion pumps, neuroreceptors, choline esterase, monoamine oxidase and other enzymes related to signal transduction pathways. A typical feature of SM is their ability to modulate more than one molecular target; thus, additive and even synergistic activities can be expected.

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Section: Other Endogenous Mutagens In Plantsmentioning

confidence: 99%

Molecular Modes of Action of Defensive Secondary Metabolites

Wink

Schimmer

2010

Functions and Biotechnology of Plant Secondary Metabolites

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“…In addition, bleomycin induced x-linked gene mutation in Drosophila [22] and Gentamycin induced CA in human lymphocytes [23]. Morimoto et al [24] reported that gentisin and isogentisin were mutagenic for the TA100 strain of S. typhimurium. Griseofulvin induced the polyploidy in male germ cells [25] and polyploidy in human peripheral lymphocytes when administered orally [26].…”

Section: Discussionmentioning

confidence: 99%

No significant increase in chromosome aberrations and sister chromatid exchanges in cultured human lymphocytes treated with spiramycin

Rencüzoğulları¹,

İla²,

Topaktaş³

et al. 2001

Teratog Carcinog Mutagen

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In this study, the chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) were investigated in human lymphocytes treated with spiramycin antibiotic (trade name, rovamycin). Spiramycin did not induce the CAs and SCEs, and also did not decrease the mitotic index (MI). However, spiramycin decreased the replication index (RI) only at 48 h treatment times. Teratogenesis Carcinog. Mutagen. 22:51-58, 2002.

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“…Por ejemplo, dos 2-hidrossixantona aislados de las raíces de algunas Gentianaceae, gentisina e isogentisina, presentan una actividad mutagenica al ensayo de Ames. La primera xantona es menos activa, quizá por la presencia de un grupo metoxílico en 3 que disminuye la solubilidad ( Morimoto et al, 1983) Otros estudios sobre la actividad mutagenica de los xantones han sido reportados. (Matsushima et al, 1985).…”

Section: Actividades Biológicasunclassified

Las Gentianaceae: botánica, toquímica y actividad biológica

Vidari¹,

Vita‐Finzi²

2010

lgr

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<p>Este artículo es una revisión actualizada sobre los metabolitos secundarios de la familia de las Gentianaceae. Estas plantas se emplean en la medicina tradicional de numerosos países y presentan actividad biológica interesante. Después de haber detallado botánicamente esta familia de plantas, que ha sido y que sigue siendo muy estudiada, se recogen los estudios toquímicos sobre numerosas especies. Los metabolitos característicos son los xantonas, una clase de compuestos no muy difundidos en el mundo vegetal. Son característicos también derivados de los seco-iridoides, y algunos alcaloides.</p>

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Mutagenic activities of gentisin and isogentisin from Gentianae radix (Gentianaceae)

Cited by 31 publications

References 11 publications

Molecular Modes of Action of Defensive Secondary Metabolites

Molecular Modes of Action of Defensive Secondary Metabolites

No significant increase in chromosome aberrations and sister chromatid exchanges in cultured human lymphocytes treated with spiramycin

Las Gentianaceae: botánica, toquímica y actividad biológica

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