Mutagenic activities of ten imidazole derivatives in Salmonella typhimurium

Abstract

Ten imidazole derivatives were tested for mutagenicity in Salmonella typhimurium strains TA98 and TA100 both in the absence and presence of metabolic activation by the microsomal fraction S9 mix. In a general manner, derivatives tested exhibited a greater mutagenic activity in the TA100 strain comparing to the responses in TA 98. In the standard plate incorporation assay, 8 of these substances (80%) were found to be mutagenic for at least one of the two strains in the presence or absence of metabolic activation. Two compounds showed positive results in TA98 and 6 compounds were also mutagenic in TA100 without S9. In the presence of S9 mix, all of the 10 substances were non-mutagenic in TA98, whereas 4 compounds were positive in TA100. The results suggested the mutagenic potentials of the imidazole derivatives particularly inducing the reversion of base-pair substitutions. According to the structure-activity relationships phenyl groups in position 2 with different substituents can confer the mutagenic activity of the tested compounds. Methyl groups in different positions of these phenyl substituents can cause different types of mutations. This mutagenic effect is observed more clearly when the phenyl group is inhibited with a nitro group.

Antioxidant, biofilm inhibition and mutagenic activities of newly substituted fibrates

“…Literature shows that the position and nature of substituents on phenyl ring greatly effect the mutagenic results [29] as in compound 4d chloro group is present at Meta position of phenyl ring and causes mutagenicity against both strains of Salmonella TA98 and TA 100 while in compound 4e nitro group is also present at meta position but it is mutagenic only for one strain. It shows that chloro and nitro groups at meta position creates greater interaction with DNA and becomes stable [30] and this stability causes genetic mutation in bacterial strains.…”

Induction of Micronuclei, Base-pair Substitution Mutation and Excision-repair Deficient by Polluted Water from Asa River in Nigeria

“…Tobacco wastewater was also shown to be toxic to coliforms (Sponza, 2002). Therefore, this test has a large anticipating value for cancer formation (Aydogan and Kutlu 2007;Benkli et al, 2009).…”

Synthesis of Novel Derivatives of Imidazo[2,1-c][1,2,4]Triazine from Biologically Active 4-Arylidene-2-Hydrazino-1-Phenyl-1H-Imidazol-5(4H)-Ones and Evaluation of their Antimicrobial Activity

“…6 In the past years, a large number of imidazolinone derivatives have been prepared and studied for their antimicrobial activities. [7][8][9][10] Moreover, it has been reported that if imidazol-5(4H)-ones are coupled to the benzylidene moiety, the resulting compounds possess significant antimicrobial activity. 11 In addition, 1,2,4-triazine derivatives have been found to exhibit a variety of biological roles such as antifungal, anti-HIV, anti-malarial, antihypertensive and antibacterial activities.…”