Mutagenic activity of 2-phenylbenzotriazole derivatives related to a mutagen, PBTA-1, in river water

Shiozawa, Tatsushi; Suyama, Kayoko; Nakano, Kouji; Nukaya, Haruo; Sawanishi, Hiroyuki; Oguri, Atsuko; Wakabayashi, Keiji; Terao, Yoshiyasu

doi:10.1016/s1383-5718(99)00069-8

Cited by 31 publications

(23 citation statements)

References 11 publications

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“…Eight kinds of 2-phenylbenzotriazole-type compounds (PBTAs) were isolated and identified from water samples collected from several river waters in Japan, and these compounds showed strong mutagenicity in S. typhimurium YG 1024 with S9 mix [45][46][47][48][49][50]. It was reported that the mutagens were presumedly formed from azo dyes used as an industrial material for dyeing by reduction and chlorination during industrial processes in dyeing factories and treatment at sewage plants as shown in Fig.…”

Section: Azo Dyes and Their Derivativesmentioning

confidence: 99%

Electrochemical Oxidation of Prednisolone at Glassy Carbon Electrode and Its Quantitative Determination in Human Serum and Tablets by Osteryoung Square Wave Voltammetry

Yılmaz¹,

Skrzypek²,

Dilgin³

et al. 2007

CAC

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One of the most important ecological problems is mutagenic pollution in the environment, and the determination of mutagenic compounds in environmental samples is of special interest. In the current article, a review of the liquid chromatography-mass spectrometry (LC/MS) based methods published so far for the determination of mutagens in the environment is presented. Mutagens included in this review are polycyclic aromatic compounds, heterocyclic aromatic amine compounds, azo dyes, aldehydes and pesticides. Advanced aspects of current analysis of mutation research using LC/MS, including analysis of urinary metabolites of mutagens and DNA modification, are also discussed.

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Section: Azo Dyes and Their Derivativesmentioning

confidence: 99%

Electrochemical Oxidation of Prednisolone at Glassy Carbon Electrode and Its Quantitative Determination in Human Serum and Tablets by Osteryoung Square Wave Voltammetry

Yılmaz¹,

Skrzypek²,

Dilgin³

et al. 2007

CAC

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“…73) were identified as environmental pollutants endowed with mutagenic activity on Salmonella [303]. Considering that genotoxic compounds may play a role in the development of various diseases such as cancer, SAR analysis on PBTAs, all showing comparable mutagenicity, highlighted the relevance for a primary amino group [304e308], along with the planarity of the 2-phenylbenzotriazole ring and halogen groups [309].…”

Section: Mutagenic Antioxidant and Antiemetic Activity Of Benzotriazolementioning

confidence: 99%

Benzotriazole: An overview on its versatile biological behavior

Briguglio

Piras

Corona

et al. 2015

European Journal of Medicinal Chemistry

174

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Discovered in late 1960, azoles are heterocyclic compounds class which constitute the largest group of available antifungal drugs. Particularly, the imidazole ring is the chemical component that confers activity to azoles. Triazoles are obtained by a slight modification of this ring and similar or improved activities as well as less adverse effects are reported for triazole derivatives. Consequently, it is not surprising that benzimidazole/benzotriazole derivatives have been found to be biologically active. Since benzimidazole has been widely investigated, this review is focused on defining the place of benzotriazole derivatives in biomedical research, highlighting their versatile biological properties, the mode of action and Structure Activity Relationship (SAR) studies for a variety of antimicrobial, antiparasitic, and even antitumor, choleretic, cholesterol-lowering agents.

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“…The dyes end up in the water bodies due mainly to the use of the activated sludge treatment in the effluent treatment plants, which has been shown to be ineffective in removing the toxicity and coloring of some types of dye [33,60,66,67]. Moreover, the reduction of azo dyes by sodium hydrosulfite and the successive chlorination steps with hypochlorous acid, can form 2-benzotriazoles fenilbenzotriazol (PBTA) derivatives and highly mutagenic aromatic amines, often more mutagenic than the original dye [68]. In an aquatic environment, this dye reduction can occur in two phases: 1) The application of reducing agents to the newly-dyed fibers to remove the excess unbound dye, which could lead to "bleeding" of the fabrics during washing, and 2) The use of reducing agents in the bleaching process, in order to make the effluent colorless and conform with the legislation.…”

Section: Finishing and Waste Watermentioning

confidence: 99%