Mutagenic and genotoxic evaluation of bisphenol F diglycidyl ether (BFDGE) in prokaryotic and eukaryotic systems

Determination of bisphenol diglycidyl ethers in topical dosage forms

“…The concentrations of BADGE (∼4 g l −1 ) found in the cream from the accelerated study, which should resemble an extreme worst-case situation is, however, orders of magnitude lower than the concentrations considered to cause any effect with regards to mutagenic, genotoxic and antiandrogen effects in vitro [3,6,8]. The specific migration limit set by the European Commission at 1 mg kg −1 for the sum of BADGE, BADGE·H 2 O, BADGE·HCl, BADGE·2HCl and BADGE·H 2 O·HCl [10] is also much higher than the concentrations found in the cream from the accelerated study.…”

“…This is evident from the estimated log K p values that predict BADGE to possess the highest skin permeation rate of the compounds studied. Furthermore, BADGE has previously been found to be approximately 10 times more potent than BADGE·H 2 O in in vitro mutagenicity assays, where BADGE·2H 2 O and BADGE·2HCl did not have any effect [4]. In in vitro mutagenicity and genotoxicity assays, BADGE has also been found to be more potent than BFDGE [6].…”

“…1) as leachables in canned food and drinks has received much attention lately due to the suspected mutagenic, genotoxic and anti-androgenic effects of the compounds [1][2][3][4][5][6][7][8].…”

Determination of bisphenol A diglycidyl ether and its hydrolysis and chlorohydroxy derivatives by liquid chromatography–mass spectrometry

“…Recent studies about the toxicity of these compounds, [3][4][5] have demonstrated that the genotoxic effect of bisphenol A diglycidyl ether (BADGE) was stronger than the genotoxic effect of BADGE·H 2 O and BADGE·2H 2 O. Regarding BADGE·HCl, its genotoxic effect was comparable to those obtained to BADGE·H 2 O.…”

A topological sub-structural approach to the mutagenic activity in dental monomers. 2. Cycloaliphatic epoxides

“…Another study of mutagenicity on this kind of compounds was reported by Sueiro et al [4] concerning the epoxy resin bisphenol F diglycidyl ether (BFDGE). This epoxide was examined for its mutagenicity in prokaryotic assays (S. typhimurium His (2 ) and Escherichia coli Trp(2 ) tests), its genotoxicity in eukaryotic systems (sister chromatid exchange) and micronucleus tests in human lymphocytes, in the presence or absence of an exogenous metabolizing system (S9 from rat liver).…”