Mutagenicity, acute toxicity, and bioaccumulation potential of six chlorinated styrenes

Tarkpea, Maria; Hagen, Inger; Carlberg, Georg E.; Kolsaker, Per; Storflor, Harry

doi:10.1007/bf01636549

Cited by 17 publications

(12 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This value is considerably lower than the 0.04/~g g-I reported for Great Lakes' Herring Gull eggs (Braune and Norstrom 1989). Octachlorostyrene is thought to be highly bioaccumulative having a 1OgKow of 7.7 (Tarkpea et al 1985), although its chronic toxicity to birds is not known. The NOEL (no observable effects level) for liver and thyroid histopathology in rats is estimated to be 0.5/~g g-1 in the diet (Chu et al 1982) which indicates low chronic toxicity.…”

Section: Resultscontrasting

confidence: 45%

β-carotene and retinoids in eggs of Great Blue Herons (Ardea herodias) in relation to St Lawrence River contamination

Boily

Champoux²,

Bourbonnais

et al. 1994

Ecotoxicology

View full text Add to dashboard Cite

: The potential use of retinoids and β-carotene as biomarkers in the eggs of the Great Blue Heron was investigated. In the spring of 1991, 65 eggs were collected from nine heronries (seven along the St Lawrence River and two reference sites). A method was specifically developed for the extraction and analysis of β-carotene and the retinoids in heron egg yolks by reversed-phase HPLC. When results were expressed either as the molar ratio of retinol: retinyl palmitate or as retinyl palmitate concentration, significant differences were found between colonies; however, retinyl palmitate concentration was deemed the better biomarker because it was not significantly influenced by embryonic stage of development. Retinyl palmitate concentrations in freshwater colonies were negatively related to PCB congeners Nos 105 and 118 as well as their TCDD-EQ values (p < 0.02, r (2)=0.78). Egg tetrachloro-mono-ortho biphenyl concentrations were also negatively related to retinyl palmitate (p < 0.005, r (2)=0.90). With the exception of the two mono-ortho co-planar congeners detected in the present study, the contamination levels found in heron eggs were well below those found for other bird species in the Great Lakes area and, so far, no detrimental effects have been reported in Great Blue Heron populations in Quebec. These results suggest that retinyl palmitate may be useful as a sensitive and non-invasive biomarker for monitoring organochlorine contaminant effects in the Great Blue Heron in freshwater sites.

show abstract

Section: Resultscontrasting

confidence: 45%

β-carotene and retinoids in eggs of Great Blue Herons (Ardea herodias) in relation to St Lawrence River contamination

Boily

Champoux²,

Bourbonnais

et al. 1994

Ecotoxicology

View full text Add to dashboard Cite

show abstract

“…Octachlorostyrene, a by-product of organic chlorine compounds, is an environmental contaminant in the Great Lake regions of North America and the Norwegian coast in Europe, 27,28) and was found to be concentrated in the human plasma of aluminum foundry workers. 29,30) In vivo experiments have recognized histological and functional changes in the thyroid.…”

Section: Discussionmentioning

confidence: 99%

Several Environmental Pollutants Have Binding Affinities for Both Androgen Receptor and Estrogen Receptor .ALPHA..

Satoh

Nagai

Aoki

2001

JOURNAL OF HEALTH SCIENCE

View full text Add to dashboard Cite

We determined the binding affinities of some chemicals suspected of having endocrine-disrupting effects for androgen and/or estrogen receptors (ADR and ERα) by a non-radioisotope (RI) receptor binding assay. Tributyltin had the highest binding affinity for ADR with an IC 50 of 7.6 × 10 -6 M, but no affinity for ERα. Bisphenol A and 4-nonylphenol strongly bound to both ADR (IC 50 values of 7.9 × 10 -6 and 1.3 × 10 -5 M, respectively) and ERα (IC 50 values of 7.8 × 10 -6 and 7.2 × 10 -7 M, respectively). Octachlorostyrene had affinity for both receptors (IC 50 for ADR, 2.7 × 10 -5 M; and for ERα, 7.0 × 10 -5 M). Although 4-octylphenol had a low affinity for ADR, it had a high affinity for ERα (IC 50 of 9.8 × 10 -6 M). Di-n-butyl phthalate, dicyclohexyl phthalate, and di(2-ethylhexyl) phthalate had low affinities for both ADR and ERα. The affinity of benzophenone was low for both receptors and nbutylbenzene had no affinity for either. Styrene trimers such as 1a-phenyl-4a-(1′-phenylethyl)tetralin (ST-2), 1a-phenyl-4e-(1′-phenylethyl)tetralin (ST-3), 1e-phenyl-4a-(1′-phenylethyl)tetralin (ST-4), and 1e-phenyl-4e-(1′-phenylethyl)tetralin (ST-5) had relatively high affinities, with IC 50 values of 1.2-3.1 × 10 -5 M. Styrene dimers showed lower affinities for ADR than the trimers. Some styrene oligomers have been previously reported to have binding affinities for ERα. These findings suggest that some chemicals possess binding affinities for ADR and ERα. It is necessary to examine the effects of substances on various hormone receptors to elucidate their endocrine-disrupting activities.

show abstract

“…This harpacticoida is a habitat general ist (Therriault and Kolasa, 2000). In addition, N. spin ipes prefers sandy sediments, where it is an interstitial species or it inhabits the phytal as a plankton species (De Troch et al, 2005;Karlsson and Eklund, 2004;Tarkpea et al, 1985).…”

Section: Biology and Ecology Of N Spinipesmentioning

confidence: 99%

Invasion of brackish water harpacticoida Nitocra spinipes (Boeck, 1865) (Crustacea: Copepoda: Harpacticoida) into Lake Ladoga

Дудакова

2012

Russ J Biol Invasions

View full text Add to dashboard Cite

Mutagenicity, acute toxicity, and bioaccumulation potential of six chlorinated styrenes

Cited by 17 publications

References 15 publications

β-carotene and retinoids in eggs of Great Blue Herons (Ardea herodias) in relation to St Lawrence River contamination

β-carotene and retinoids in eggs of Great Blue Herons (Ardea herodias) in relation to St Lawrence River contamination

Several Environmental Pollutants Have Binding Affinities for Both Androgen Receptor and Estrogen Receptor .ALPHA..

Invasion of brackish water harpacticoida Nitocra spinipes (Boeck, 1865) (Crustacea: Copepoda: Harpacticoida) into Lake Ladoga

Contact Info

Product

Resources

About