Mutagenicity and infertility following administration of lead sub-acetate to Swiss male mice

Varma, M. M.; Adeyemi, Alaba Oladipupo

doi:10.1007/bf01926307

Cited by 42 publications

(6 citation statements)

References 5 publications

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“…13,16,32 Fertility of lead exposed male mice was also shown to decrease. 14,33 It was suggested that in adult male rats lead acts both at the level of the hypothalamic ± pituitary unit and directly at the gonadal sites to disrupt reproduction. 24,30 Other workers found that the short-term intraperitoneal administration of 100 or 200 mg/kg/day aluminum nitrate 12 and chronic diatary exposure of 3500 p.p.m.…”

Section: Discussionmentioning

confidence: 99%

Assessment of aggression, sexual behavior and fertility in adult male rat following long-term ingestion of four industrial metals salts

1998

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1 The effect of long-term ingestion of the industrial metals salts, manganese sulfate, aluminum chloride, lead acetate and copper chloride was investigated on aggression, sexual behavior and fertility in male rat. Adult male rats ingested solutions of these salts along with drinking water at a concentration of 1000 p.p.m. for 12 weeks. 2 Male rat sexual behavior was suppressed after the ingestion of manganese sulfate, aluminum chloride, lead acetate and copper chloride. The ingestion of solutions of these salts markedly prolonged the intromission and ejaculation latencies. Aluminum chloride and copper chloride reduced the copulatory efficiency. 3 Male rat aggression was also abolished after the ingestion of manganese sulfate, aluminum chloride, lead acetate and copper chloride. The ingestion of solutions of these salts markedly suppressed lateralizations, boxing bouts, fight with stud male and ventral presenting postures. 4 Fertility was reduced in male rats ingested with lead acetate. The total number of resorptions was increased in female rats impregnated by males ingested with manganese sulfate and lead acetate. 5 Body, absolute or relative testes, seminal vesicles weights were dropped in adult male rats ingested with manganese sulfate, aluminum chloride, lead acetate and copper chloride. However, the absolute or relative preputial gland weights were not affected. Collectively, these results suggest that the long-term ingestion of manganese sulfate, aluminum chloride, lead acetate and copper chloride would have adverse effects on sexual behavior, territorial aggression, fertility and the reproductive system of the adult male rat.

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Section: Discussionmentioning

confidence: 99%

Assessment of aggression, sexual behavior and fertility in adult male rat following long-term ingestion of four industrial metals salts

1998

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“…Varma et al (1974) reported that dominant lethal effects were induced in mice fed 2% aqueous lead subacetate in their drinking-water for 28 days (This c1aim is difficult to interpret because of the heterogeneity of the data and the inadequacy of the statistical evaluationl .…”

Section: Route and Dosagementioning

confidence: 99%

Evaluation of the carcinogenic risk of chemicals to humans

Hamilton¹

1979

Science of The Total Environment

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“…In the Syrian harnster lead induces neoplastic changes in the bronchio-alveolar area [25,26]. It also produces infertility in mice [27] and reduces the reproductive ability of rats [28][29][30]. In Drosophila melanogaster lead induces enzymatic alterations in esterase and triose phosphate isomerase [31] and affects non disjunction [8].…”

Section: Introductionmentioning

confidence: 99%

Heavy Protein Alteration under the Effects of Lead Acetate in Bactrocera cucurbitae

Haq

2021

J. Basic Appl. Sci.

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Lead is supposed to be an important poisonous waste which could contaminate the environment, therefore, insects could be influenced easily by the lead., Bactrocera cucurbitae was studied at 48 hours post treatment, under the effects of lead acetate, in different concentrations of 0.125 mg., 0.25 mg., 0.5 mg, 1.0 mg and 2.0 mg. It was observed that under the effects of lead abnormalities and deformity were developed in the larvae of flies. Thus these flies could present a useful module for the quick transmission of the environmental hazards due to lead contamination, which exerts a specific physiological and morphological effect on these flies.

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Mutagenicity and infertility following administration of lead sub-acetate to Swiss male mice

Cited by 42 publications

References 5 publications

Assessment of aggression, sexual behavior and fertility in adult male rat following long-term ingestion of four industrial metals salts

Assessment of aggression, sexual behavior and fertility in adult male rat following long-term ingestion of four industrial metals salts

Evaluation of the carcinogenic risk of chemicals to humans

Heavy Protein Alteration under the Effects of Lead Acetate in Bactrocera cucurbitae

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