Mutagenicity and tumor initiating activity of methylated benzo[k]fluoranthenes

Amin, Shantu; Hussain, Nalband; Balanikas, George; Huie, Keith; Hecht, Stephen S.

doi:10.1016/0304-3835(85)90059-x

Cited by 14 publications

(10 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the carcinogenic and toxic potential of PAHs relies on their metabolites. However, several of the tumorigenic PAHs (i.e., the nonaltemant PAHs) discussed in this report do not have a bay region, or have been shown not to be similarly activated via a simple bay region epoxide (e.g., Amin et al, 1985aAmin et al, , 1985b. This observation has important implications regarding the expression of carcinogenicity for the nonaltemant PAHs.…”

Section: Mechanisms Of Actionmentioning

confidence: 76%

Atsdr Evaluation of Health Effects of Chemicals. Iv. Polycyclic Aromatic Hydrocarbons (PAHs): Understanding a Complex Problem

et al. 1996

View full text Add to dashboard Cite

Polycyclic Aromatic Hydrocarbons (PAHs) are a group of chemicals that are formed during the incomplete burning of coal, oil, gas, wood, garbage, or other organic substances, such as tobacco and charbroiled meat. There are more than 100 PAHs. PAHs generally occur as complex mixtures (for example, as part of products such as soot), not as single compounds. PAHs are found throughout the environment in the air, water, and soil. As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals, including PAHs (ATSDR, 1995), found at facilities on the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) and which pose the most significant potential threat to human health, as determined by ATSDR and the Environmental Protection Agency (EPA). These profiles include information on health effects of chemicals from different routes and durations of exposure, their potential for exposure, regulations and advisories, and the adequacy of the existing database. Assessing the health effects of PAHs is a major challenge because environmental exposures to these chemicals are usually to complex mixtures of PAHs with other chemicals. The biological consequences of human exposure to mixtures of PAHs depend on the toxicity, carcinogenic and noncarcinogenic, of the individual components of the mixture, the types of interactions among them, and confounding factors that are not thoroughly understood. Also identified are components of exposure and health effects research needed on PAHs that will allow estimation of realistic human health risks posed by exposures to PAHs. The exposure assessment component of research should focus on (1) development of reliable analytical methods for the determination of bioavailable PAHs following ingestion, (2) estimation of bioavailable PAHs from environmental media, particularly the determination of particle-bound PAHs, (3) data on ambient levels of PAHs metabolites in tissues/fluids of control populations, and (4) the need for a critical evaluation of current levels of PAHs found in environmental media including data from hazardous waste sites. The health effects component should focus on obtaining information on (1) the health effects of mixtures of PAHs particularly their noncarcinogenic effects in humans, and (2) their toxicokinetics. This report provides excerpts from the toxicological profile of PAHs (ATSDR, 1995) that contains more detailed information.

show abstract

Section: Mechanisms Of Actionmentioning

confidence: 76%

Atsdr Evaluation of Health Effects of Chemicals. Iv. Polycyclic Aromatic Hydrocarbons (PAHs): Understanding a Complex Problem

et al. 1996

View full text Add to dashboard Cite

show abstract

“…However, several of the tumorigenic PAHs (i.e., the nonaltemant PAHs) discussed in this profile do not have a bay region, or have been shown not to be similarly activated via a simple bay region epoxide (e.g., Amin et al 1985aAmin et al , 1985b. This observation has important implications regarding the expression of carcinogenicity for the nonalternant PAHs.…”

Section: Mechanisms Of Actionmentioning

confidence: 83%

“…Available data on several of the nonaltemant tumorigenic PAHs discussed in this profile indicate that they exert their adverse effects by mechanisms that differ from those that have been more recently elucidated for altemant PAHs (Amin et al , 1985bRice et al 1987b (LaVoie et al 1993b;Marshall et al 1993;Weyand et al 1993aWeyand et al , 1993b.…”

Section: Health Effectsmentioning

confidence: 99%

“…Studies on the mutagenic activity of benzofilfluoranthene and benzo[k]fluoranthene have also indicated that these nonalternant PAHs are mutagenic in S. typhimurium TAl00 (Amin et al 1985b;LaVoie et al 1979LaVoie et al , 1980aWeyand et al , 1992. There is also evidence that application of either of these PAHs to mouse skin results in DNA adduct formation (Hughes et al 1993;LaVoie et al 1991aLaVoie et al , 1991bWeyand et al 1987Weyand et al , 1993a Benzo[g,h,i]perylene has been reported to be mutagenic in S. typhimurium and to cause DNA damage in E. coli.…”

Section: Health Effectsmentioning

confidence: 99%

See 1 more Smart Citation

The Gulf Oil Spill

2011

View full text Add to dashboard Cite

“…In all of these studies, benzo[b]-fluoranthene exhibited a significant carcinogenic activity. (110,111,119,120), by intraperitoneal injection into newborn mice in two studies (114,121) and by intrapulmonary implantation into rats in one study (114 (122), intraperitoneal injection into newborn mice in one study (114), and intrapulmonary implantation into rats in one study (118 …”

Section: Workplace Methodsmentioning

confidence: 99%

Polycyclic Aromatic Hydrocarbons and Azaaromatic Compounds

Baxter¹,

Warshawsky²

2012

Patty's Toxicology

View full text Add to dashboard Cite

Polycyclic aromatic hydrocarbons (PAHs) are moderately reactive, but undergo photochemical degradation in the atmosphere, and are widely used as chemical raw materials. Aromatic hydrocarbons cause local irritation and changes in endothelial cell permeability and are absorbed rapidly. Accumulation of aromatic hydrocarbons in marine animals occurs to a greater extent and retention is longer compared to alkanes. Toxicity of polynuclear aromatics has been reported comprehensively. It has been reported that exposure to a variety of complex mixtures containing these chemicals, such as soot, coal tar and pitch, mineral oils, coal gasification residues, and cigarette smoke has historically been associated with induction of cancer. Naphthalene causes cataracts in the eyes of experimental animals. Its vapors may cause severe systemic injury. Alkylbenzenes are readily aspirated and produce instant death via cardiac arrest and respiratory paralysis. In general, the acute toxicity of alkylbenzenes is higher for toluene than that for benzene and decreases further with increasing chain length of the substituent, except for highly branched C 8 to C 18 derivatives. Polycyclic aromatic hydrocarbons are metabolized through epoxides and hydroxides and are excreted as conjugates.

show abstract

Mutagenicity and tumor initiating activity of methylated benzo[k]fluoranthenes

Cited by 14 publications

References 4 publications

Atsdr Evaluation of Health Effects of Chemicals. Iv. Polycyclic Aromatic Hydrocarbons (PAHs): Understanding a Complex Problem

Atsdr Evaluation of Health Effects of Chemicals. Iv. Polycyclic Aromatic Hydrocarbons (PAHs): Understanding a Complex Problem

The Gulf Oil Spill

Polycyclic Aromatic Hydrocarbons and Azaaromatic Compounds

Contact Info

Product

Resources

About