Elements and Their Compounds in the Environment 2004
DOI: 10.1002/9783527619634.ch21
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Mutagenicity, Carcinogenicity, and Teratogenicity

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Cited by 5 publications
(4 citation statements)
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References 183 publications
(70 reference statements)
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“…Even though Pb at the highest concentrations of 26.32 µg cm −2 at near-LC 10 concentration did not show any significant damage to DNA in the comet assay-confirming that Pb, unlike Cd, is not genotoxic even at LC 10 concentration in a 48-h study. In support of these results, most authors report that Cd induces DNA strand breaks, sister chromatid exchanges, and chromosome aberrations in plant, mammalian and human cells [24][25][26] at relatively low exposure and well below the 48-h LC 10 concentration.…”
Section: Discussionsupporting
confidence: 50%
“…Even though Pb at the highest concentrations of 26.32 µg cm −2 at near-LC 10 concentration did not show any significant damage to DNA in the comet assay-confirming that Pb, unlike Cd, is not genotoxic even at LC 10 concentration in a 48-h study. In support of these results, most authors report that Cd induces DNA strand breaks, sister chromatid exchanges, and chromosome aberrations in plant, mammalian and human cells [24][25][26] at relatively low exposure and well below the 48-h LC 10 concentration.…”
Section: Discussionsupporting
confidence: 50%
“…The results confirm that inhaling lead induces systemic DNA damage, but certain organs, such as the lung and the liver, are special targets of this metal, partly depending on the duration of exposure. As the lead concentrations used in this work were lower than those used in prior studies /198199/, the authors concluded that even at low levels of inhalation exposure, this metal could induce DNA damage and should be considered a risk for living organisms.…”
Section: Mechanisms Of Lead-induced Neurotoxicitymentioning
confidence: 60%
“…Their results suggest that organic compounds are generally more active, in terms of genotoxicity, than inorganic compounds (5,15,18,20). The binding of this metal to sulfhydryl groups of glutathione blocks its function as a free radical scavenger (19).…”
Section: Resultsmentioning
confidence: 99%