Mutagenicity, Carcinogenicity, and Teratogenicity of Insecticides

Moutschen-Dahmen, J.; Moutschen-Dahmen, M.; Degraeve, N.

doi:10.1007/978-1-4613-2643-4_4

Cited by 9 publications

(3 citation statements)

References 238 publications

(236 reference statements)

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“…The mutagenicity of dichlorvos has been extensively studied and reviewed (IARC, 1991;Moutschen-Dahmen et al, 1984;Wild, 1975). In bacteria and yeast, dichlorvos was found to have a mutagenic effect by many studies (Ashwood-Smith, 1972;Benigni et al, 1980;Kada et al, 1980;Nagy et al, 1975;Shirasu et al, 1976;Voogd et al, 1972).…”

Section: D) Mutagenicity Studies In Bacteria and Yeastmentioning

confidence: 99%

“…However, the DNA-alkylating ability of dichlorvos in vivo has been found to be very weak (FAO/WHO, 1993;Segerback, 1981). Dichlorvos has also been found to be more mutagenic in strains of DNA polymerase-deficient bacteria, indicating that the DNA repair machinery may play a role in preventing some of the dichlorvos damage (Moutschen-Dahmen et al, 1984;Rosenkranz, 1973). In contrast, another study found dichlorvos to be mutagenic in both excision-repair competent, as well as excision-repair deficient strains of Escherichia coli (Nagy et al, 1975).…”

Section: D) Mutagenicity Studies In Bacteria and Yeastmentioning

confidence: 99%

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Critical Evaluation of Dichlorvos’ Breast Cancer Risk

Gandhi

Snedeker

2002

Comments on Toxicology

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Section: D) Mutagenicity Studies In Bacteria and Yeastmentioning

confidence: 99%

Section: D) Mutagenicity Studies In Bacteria and Yeastmentioning

confidence: 99%

Critical Evaluation of Dichlorvos’ Breast Cancer Risk

Gandhi

Snedeker

2002

Comments on Toxicology

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“…On the other hand, some organophosphorus pesticides can induce mutations in microorganisms but most of them are generally ineffective in mammals treated in vivo (4).…”

Section: Introductionmentioning

confidence: 99%

Mutagenic efficiency of organophosphorus insecticides used in combined treatments.

Degraeve¹,

Chollet²,

Moutschen³

1985

Environ Health Perspect

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Male mice (Q strain) received two consecutive injections of organophosphorus insecticides: a phosphonate (trichlorfon) was combined to a thiophosphate (methylparathion) or a dithiophosphate (malathion or methylazinphos) in order to evaluate the interactions at the genetic and cytogenetic levels.No increase in chromosome damage was observed in bone marrow cells, spermatogonia, and primary spermatocytes. In a dominant lethal mutation assay, the frequency of postimplantation lethality was not significantly increased over the control level. The percentage of preimplantation losses was enhanced, probably due to a toxic effect on male germ cells.

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