Mutagenicity of airborne particles

Fukino, Hideki; Mimura, Shuji; Inoue, Kazuhito; Yamane, Yasuhiro

doi:10.1016/0165-1218(82)90133-1

Cited by 39 publications

(8 citation statements)

References 17 publications

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“…Clearly, other biologically-active compounds were present in the CX fraction from both campaigns, but particularly the winter one, since most of the winter CX activity was of the direct-acting type. Nitrated PAH are possible candidates: (a) wintertime maxima of N02 -and NOs -in particles and of NO and N02 in the atmosphere have been observed (Fukino et al, 1982); (b) inorganic oxides of nitrogen have been shown by several investigators to react with PAH to create direct-acting mutagens (e.g., Pitts et al, 1978); and (c) nitro-PAH are responsible for a significant portion of the total mutagenicity of diesel particle extracts Salmeen et aI., 1984) and extracts from other combustion sources (Kamens et aI., 1984). In fact, nitrated PAH have recently been found in these CX extracts (J. Butler, NYU, personal communication).…”

Section: Discussionmentioning

confidence: 99%

Short-Term Bioassays in the Analysis of Complex Environmental Mixtures IV

1985

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Section: Discussionmentioning

confidence: 99%

Short-Term Bioassays in the Analysis of Complex Environmental Mixtures IV

1985

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“…May be a primary source of atmospheric, direct-acting mutagens. It is suggested that secondary direct-acting mutagens might be partly formed by the nitration of polycyclic-aromatic hydrocarbons (PAH) with NO 2 in the atmosphere because concentrations of B[a]P, NO 2 and NO-3 increased simultaneously when the highest directacting mutagenic activity was observed" [4].…”

Section: Mutat Res Oct-nov 1982mentioning

confidence: 99%

COVID-19 New variant and air pollution relationship: how airborne mutagens agent can act on genoma viruses expression: Hypothesis of work

Luisetto¹,

Almukthar²,

Hamid³

et al. 2021

Int J Clin Virol

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Before actual COVID-19 pandemia coronavirus was not so dangerous like now. In December 2019 - January 2020 in Wuhan first and then in other places this coronavirus was responsible of a first wave of severe pulmonitis responsible of many deaths. Wuhan and other region involved first was high level air polluted and industrial area. New COVID-19 variant in last part of 2020 and in first month of 2021 was responsible of great diffusion of this pandemic disease. UK, South Africa and brasilian new variant show higher diffusion then the first wave of COVID-19. Aim of this work is to analyze relationship with air pollution and the possibility that mutagen substantia inside of this microenvironment can produce new variant trough an genetic pressure process. RNA viruses are normally subjected by natural mutation but some phenomena can contribute to accelerate this process and their airborne – aeresols microenvironment is relevant. Some air pollutants are recognized as mutagen factors by literature.

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“…The Salmonella assay, in particular, has provided investigators with a simple and inexpensive method whereby organic extracts of airborne particulate matter can be tested for mutagenic activity. This assay, developed nearly two decades ago [Ames et al, 19731, has been used to address several key issues pertaining to air pollution, including the characterization of principal sources of genotoxic emissions [Alfheim et al, 1983;Daisey et al, 1980;Fukino et al, 1982;Goto et al, 1982b;Huisingh et al, 1979;Lewis et al, 1988;Lofroth, 1978;Ohnishi et al, 1980;Matsushita et al, 1986;Mdler and Alfheim, 1983;Mumford and Lewtas, 19821, the assessment of individual atmospheric constituents [see, for example, Graedel et al, 19861, the evaluation of meteorological and atmospheric parameters that influence genotoxicity [Alfheim and Mdler, 1981;Claxton et al, 1990;van Houdt et al, 19871, and the monitoring of industrial and rural areas [Alink et al, 1983;Barale et al, 1989;de Raat et al, 1985;Takedaet al, 1984;Tokiwa et al, 19831. In addition, the Salmonella assay has been used to correlate the mutagenicity of urban air particulate matter with elevated lung cancer mortality rates [Walker et al, 1982;Mumford et al, 19871. A variety of modifications to the standard Salmonella plate-incorporation assay have been reported in recent years, each designed to improve test sensitivity or to accommodate special test considerations. One such modification is the preincubation method first introduced by Yahagi et al…”

Section: Introductionmentioning

confidence: 99%

Detection of direct‐acting mutagens in ambient air: A comparison of two highly sensitive mutagenicity assays

Houk¹,

Goto²,

Endō³

et al. 1992

Environ and Mol Mutagen

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Ambient air has been shown to contain numerous hazardous pollutants, many of which are known or suspected carcinogens and mutagens. Bioassays play a prominent role in the characterization of these genotoxic pollutants, and as new test methods are developed, it is incumbent upon researchers to evaluate assay performance and report relative merits. In this study, two Salmonella test methods (the spiral and preincubation assays) were assessed to determine their usefulness as screening methods for monitoring direct-acting mutagens in ambient air. The spiral assay automates the conventional plate-incorporation assay and has been shown to reduce the labor, materials, and sample mass required to perform mutagenicity testing. The preincubation assay has been shown to enhance test sensitivity for certain classes of compound, thereby reducing the amount of sample required for dose-response analysis. Both assays were used to test organic extracts of airborne particulate matter collected in Tokyo during the winters of 1988 and 1990. In addition to the conventional tester strains TA98 and TA100, two newly developed YG strains were evaluated. Strains YG1024 and YG1029-derived from TA98 and TA100, respectively-contain an acetyltransferase plasmid that confers upon the strains greater sensitivity towards nitroarenes. Results from this study indicated that both assays were able to detect direct-acting mutagens in the Tokyo air samples. The mutagenic activity associated with the samples was directly related to the particle mass present in a given volume of air. Mutagenic response was greater in the spiral assay relative to the preincubation assay, especially when YG tester strains were used. The YG strains were significantly more sensitive to mutation than the TA strains in both assays, which suggests that nitroaromatics are an important class of genotoxic contaminant present in Tokyo air.

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Mutagenicity of airborne particles

Cited by 39 publications

References 17 publications

Short-Term Bioassays in the Analysis of Complex Environmental Mixtures IV

Short-Term Bioassays in the Analysis of Complex Environmental Mixtures IV

COVID-19 New variant and air pollution relationship: how airborne mutagens agent can act on genoma viruses expression: Hypothesis of work

Detection of direct‐acting mutagens in ambient air: A comparison of two highly sensitive mutagenicity assays

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