Mutans streptococci in preschool twins

Corby, Patricia; Bretz, Walter A.; Hart, Thomas C.; Filho, Morato; Oliveira, Bruno Maia; Vanyukov, Michael

doi:10.1016/j.archoralbio.2004.08.010

Cited by 30 publications

(30 citation statements)

References 15 publications

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“…Previous twin-based studies on the heritability of oral microbes have relied on culture-based and array-based (checkerboard hybridization) approaches, and contrary to our results, they have suggested that the abundance of the cariogenic S. mutans and specific pathogenic attributes such as acid production in dental plaque and saliva are highly heritable traits (Bretz et al ., 2005; Corby et al ., 2007, 2005). …”

Section: Discussionmentioning

confidence: 99%

“…For instance, contrary to what has been found in the gut, twin studies on the genetic control of the oral microbiome (saliva and plaque) have shown less or no apparent influence of additive genetic factors (Papapostolou et al ., 2011; Stahringer et al ., 2012). Yet, other twin studies have focused on the abundance of cariogenic taxa in saliva and plaque, showing that these are highly heritable traits (Corby et al ., 2007, 2005). …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Host Genetic Control of the Oral Microbiome in Health and Disease

Gómez

Espinoza

Harkins

et al. 2017

Cell Host & Microbe

173

151

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Summary Host-associated microbial communities are influenced by both host genetics and environmental factors. However, factors controlling the human oral microbiome and their impact on disease remain to be investigated. To determine the combined and relative effects of host genotype and environment on oral microbiome composition and caries phenotypes, we profiled the supragingival plaque microbiome of 485 dizygotic and monozygotic twins aged five to eleven. Oral microbiome similarity always increased with shared host genotype, regardless of caries state. Additionally, although most of the variation in the oral microbiome was determined by environmental factors, highly heritable oral taxa were identified. The most heritable oral bacteria were not associated with caries state, did not tend to co-occur with other taxa, and decreased in abundance with age and sugar consumption frequency. Thus, while the human oral microbiome composition is influenced by host genetic background, potentially cariogenic taxa are likely not controlled by genetic factors.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Host Genetic Control of the Oral Microbiome in Health and Disease

Gómez

Espinoza

Harkins

et al. 2017

Cell Host & Microbe

173

151

View full text Add to dashboard Cite

show abstract

“…We previously reported evidence from twin studies that genetic factors contribute to the salivary levels of mutans streptococci, a major caries pathogen (Corby et al, 2005a). A number of genetic factors including HLA genes have been reported to influence salivary mutans streptococci colonization and caries susceptibility in human and animal models (Abdus Salam et al, 2004;Acton et al, 1999;Ozawa et al, 2001;Suzuki et al, 1998).…”

mentioning

confidence: 99%

Heritability of Oral Microbial Species in Caries-Active and Caries-Free Twins

Corby¹,

Bretz

Hart

et al. 2007

Twin Res Hum Genet

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O ral microbes that colonize in the mouths of humans contribute to disease susceptibility, but it is unclear if host genetic factors mediate colonization. We therefore tested the hypothesis that the levels at which oral microbes colonize in the mouth are heritable. Dental plaque biofilms were sampled from intact tooth surfaces of 118 caries-free twins. An additional 86 caries-active twins were sampled for plaque from carious lesions and intact tooth surfaces. Using a reverse capture checkerboard assay the relative abundance of 82 bacterial species was determined. An integrative computational predictive model determined microbial abundance patterns of microbial species in caries-free twins as compared to caries-active twins. Heritability estimates were calculated for the relative microbial abundance levels of the microbial species in both groups. The levels of 10 species were significantly different in healthy individuals than in caries-active individuals, including, A. defectiva, S. parasanguinis, S. mitis/oralis, S. sanguinis, S. cristatus, S. salivarius, Streptococcus sp. clone CH016, G. morbillorum and G. haemolysans. Moderate to high heritability estimates were found for these species (h 2 = 56%-80 %, p < .0001). Similarity of the overall oral microbial flora was also evident in caries-free twins from multivariate distance matrix regression analysis. It appears that genetic and/or familial factors significantly contribute to the colonization of oral beneficial species in twins.

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“…Other results were obtained by Corby et al [12], who defined that SM appearance depends on hereditability in 52%, whereas on environmental factors in 48%. Two years later, Corby et al [13] conducted research, whose main aim was to check if microorganism species living in the oral cavity are hereditary.…”

Section: Discussion Caries and Periodontal Diseasesmentioning

confidence: 57%