2013
DOI: 10.1016/j.biomaterials.2013.09.028
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Mutant MCP-1 protein delivery from layer-by-layer coatings on orthopedic implants to modulate inflammatory response

Abstract: Total joint replacement (TJR) is a common and effective surgical procedure for hip or knee joint reconstruction. However, the production of wear particles is inevitable for all TJRs, which activates macrophages and initiates an inflammatory cascade often resulting in bone loss, prosthetic loosening and eventual TJR failure. Macrophage Chemoattractant Protein-1 (MCP-1) is one of the most potent cytokines responsible for macrophage cell recruitment, and previous studies suggest that mutant MCP-1 proteins such as… Show more

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Cited by 43 publications
(53 citation statements)
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“…However, treatment of aseptic and septic loosening of orthopaedic and dental implants may benefit from considering the role of the immune system [166168]. For example, blockade of pro-inflammatory mediators such as PGE2 [169], pro-inflammatory cytokines [170], or recruitment of monocyte/macrophage cells by interfering with CCL2/CCR2 axis [171, 172], or inactivation of the pro-inflammatory transcription factor NF-κB [173, 174] has been investigated. Another approach is centered on the modulation of macrophage phenotype from inactivated M0 or pro-inflammatory M1 macrophages toward the pro-remodeling M2 macrophages by using polarizing cytokines [175177].…”
Section: Opportunities For Enhancing Bone Repair By Modulating Infmentioning
confidence: 99%
“…However, treatment of aseptic and septic loosening of orthopaedic and dental implants may benefit from considering the role of the immune system [166168]. For example, blockade of pro-inflammatory mediators such as PGE2 [169], pro-inflammatory cytokines [170], or recruitment of monocyte/macrophage cells by interfering with CCL2/CCR2 axis [171, 172], or inactivation of the pro-inflammatory transcription factor NF-κB [173, 174] has been investigated. Another approach is centered on the modulation of macrophage phenotype from inactivated M0 or pro-inflammatory M1 macrophages toward the pro-remodeling M2 macrophages by using polarizing cytokines [175177].…”
Section: Opportunities For Enhancing Bone Repair By Modulating Infmentioning
confidence: 99%
“…[64] Briefly, Ti6Al4V rods were dip coated in a 5 wt.% ELP solution containing 0.15% wt.% ELP fluorescently labeled with rhodamine B isothiocyanate (Sigma). The intercondylar notch of cadaver mouse femurs was opened with successively larger needles ranging from 25-21 gauge to create a drill-hole reaching the medullary cavity.…”
Section: Methodsmentioning
confidence: 99%
“…29 Surface coatings may be applied to control a biological response to the device ( e.g. peri-implant tissue formation 21 ), but may also represent the primary function of the device ( e.g. drug coating on transdermal needles 30 ).…”
Section: Structurementioning
confidence: 99%
“…Such an LbL platform can be applied for controlled release of the 7ND protein from orthopedic implants in situ to reduce wear particle-induced inflammatory responses, thereby prolonging the lifetime of implants and reducing the need for revision surgeries. 56 …”
Section: Lbl For Delivery Of Different Biomoleculesmentioning
confidence: 99%