Mutation and Abnormal Expression of the p53 Gene in the Viral Skin Carcinogenesis of Epidermodysplasia Verruciformis

Padlewska, Kamila; Ramoz, Nicolás; Cassonnet, Patricia; Riou, G; Barrois, Michel; Majewski, Slavomir; Croissant, O; Jabłońska, Stefania; Orth, Gérard

doi:10.1046/j.0022-202x.2001.01515.x

Cited by 44 publications

(33 citation statements)

References 46 publications

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“…Ultraviolet irradiation is supposed to play a synergistic co-carcinogenic role with HPV because in EV and in immunocompromised patients skin cancers occur predominantly on parts of the body exposed to UV radiation [58, 59]. The mechanism is not clear, but we can suppose that local photo-immunosuppression may increase the risk of HPV infection.…”

Section: Discussionmentioning

confidence: 98%

Human Papillomavirus and Extragenital in situ Carcinoma

Quéreux

Nguyen

Dréno³

2004

Dermatology

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Background: The relation between human papillomavirus (HPV) and extragenital Bowen’s disease (BD) is controversial. Methods: This study used in situ hybridisation to evaluate the rate of HPV in extragenital cutaneous BD and investigated possible relations with immune status and exposure of skin to light. Results: HPV DNA was detected in 58% of 69 samples from 50 patients. The percentage of HPV detection was not significantly higher in exposed (55%) than unexposed areas (65%), and no difference in HPV rate was found between immunosuppressed and immunocompetent patients. Conclusion: Thus, this study confirms the high rate of HPV detection in extragenital cutaneous BD and suggests that there is no apparent relation concerning exposed areas and immune status.

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Section: Discussionmentioning

confidence: 98%

Human Papillomavirus and Extragenital in situ Carcinoma

Quéreux

Nguyen

Dréno³

2004

Dermatology

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“…This indicates that only a subset of EV HPV is endowed with an oncogenic potential. EV cancers usually arise on sun-exposed areas of the skin and a syncarcinogenic role of HPV5 and UVR is supported by the frequent mutations of the p53 gene in premalignant and malignant EV tumors (Padlewska et al, 2001).…”

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confidence: 99%

Human Papillomaviruses Associated with Epidermodysplasia Verruciformis in Non-Melanoma Skin Cancers: Guilty or Innocent?

Orth

2005

Journal of Investigative Dermatology

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Non-melanoma skin cancers (NMSC), namely basal cell carcinomas (BCC) and squamous cell carcinomas (SCC), represent the most common form of malignancy in fairskinned populations. Solar ultraviolet radiation (UVR), immunosuppression, and genetic constitution of the host are well-known risk factors for the development of NMSC. Epidermodysplasia verruciformis (EV), a rare genetic disease associated with a high risk of skin cancer, provided the first clue to a possible role of viruses in human skin carcinogenesis (Jablonska et al, 1972). Due to mutations in either of the related EVER1 and EVER2 genes, EV patients are abnormally susceptible to a specific group of related human papillomavirus genotypes (known as EV HPV) and to the oncogenic potential of some of these viruses (Orth, 1987;Ramoz et al, 2002). EV HPV cause widespread, inapparent infections in the general population (Antonsson et al, 2003). In EV patients, however, infection leads to persistent wartlike and macular skin lesions, and premalignant lesions and SCC develop on sun-exposed areas of the skin in about half of the patients. EV SCC harbor high copy numbers of episomal HPV genomes (HPV5 or occasionally HPV8, 14, 17, 20, or 47) and abundant transcripts of the E6 and E7 genes. Phenocopies of EV are exceptionally observed in immunosuppressed patients. EV is thus a rare experiment of nature that provides a model for studying the interaction among potentially oncogenic HPV genotypes, UVR, immunity, and genetic factors (Orth, 1987).EV HPV DNA sequences have only rarely been detected in cutaneous premalignant tumors and NMSC in non-EV patients by Southern blot hybridization, which is sensitive enough to detect one HPV genome per cell. Using highly sensitive PCR approaches, however, HPV DNA sequences were detected in 25%-65% of NMSC in immunocompetent individuals and in up to 90% of SCC in organ transplant recipients (OTR), a population at a greatly increased risk of developing SCC. Similar HPV detection rates were found for actinic keratoses (AK), the precursor lesion of SCC (reviewed in Forslund et al, 2004). These data led researchers to consider a role for HPV, especially EV HPV types, in the development of NMSC (Orth, 2004).Available epidemiological and seroepidemiological data provide some support to an association between the presence of EV HPV DNA in normal skin or eyebrow hairs or the seroreactivity to some EV HPV and an increased risk of AK and SCC (reviewed in Purdie et al, 2005;Weissenborn et al, 2005). The link between EV HPV and the development of NMSC in immunocompetent and immunosuppressed individuals, however, remains unclear (reviewed in Orth, 2004). EV HPV and non-EV cutaneous HPV types represent impressively diverse, ubiquitous viruses, which are highly prevalent in the normal skin of healthy adults (Antonsson et al, 2003). A great diversity of cutaneous HPV types, most frequently EV HPV or putative novel EV HPV-related types, is detected in AK and NMSC, and mixed infections are frequently observed in tumors of OTR patients. Furthermore, ...

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“…However, the malignant lesion of the patient in this report was located at the unexposed site (perianal region). Padlewska et al found the expression of oncoprotein p53 in the unexposed skin lesions of patients with EV and speculated that besides ultraviolet radiation, other unknown factors also play a key role in the development of EV malignant tumors [10]. This would be used to explain the occurrence of malignant transformation in the skin lesions of unexposed sites.…”

Section: Discussionmentioning

confidence: 99%

One case of epidermodysplasia verruciformis with squamous cell carcinoma at unexposed site

Liu¹,

Li²,

Zhang³

et al. 2018

biomedicalresearch

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Epidermodysplasia verruciformis (EV) is a rare disease caused by human papillomavirus (HPV) infection. Part of skin lesions at the exposed site would become malignant, but few cases with squamous cell carcinoma (SCC) transformation at unexposed sites have been reported. In December 2016, one EV patient with squamous cell carcinoma transformation at unexposed sites (perianal region) were admitted and treated at our hospital. Here we reported the clinicopathological characteristics and our surgical management of the SCC skin lesion of this EV patient. We deem that once local malignant transformation occurs, early surgical resection should be performed, and skin without lesions at the unexposed sites should be selected as the donor site for skin graft or skin flap transplantation.

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Mutation and Abnormal Expression of the p53 Gene in the Viral Skin Carcinogenesis of Epidermodysplasia Verruciformis

Cited by 44 publications

References 46 publications

Human Papillomavirus and Extragenital in situ Carcinoma

Human Papillomavirus and Extragenital in situ Carcinoma

Human Papillomaviruses Associated with Epidermodysplasia Verruciformis in Non-Melanoma Skin Cancers: Guilty or Innocent?

One case of epidermodysplasia verruciformis with squamous cell carcinoma at unexposed site

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