Mutation of Salmonella typhimurium by nitrosoguanidine

Hycanthone: A Frameshift Mutagen

“…Since hycanthone has been found to be a potent mutagen (13), administration of this compound might contribute to an increase in the drugresistant oocyte population.…”

ACTION OF N-METHYL-N'-NITRO-N-NITROSOGUANIDINE IN <i>BACILLUS SUBTILIS</i>

“…It was observed by several investigators (Mandell et al 1960, Eisenstarck et al 1965and Adelberg et al 1965) that nitrosoguanidine induced mutation efficiently in the low lethal dose range.…”

“…Eisenstarck et al (1965) studied the mutagenic action of nitrosoguanidine on Salmonella typhimurium and found that the mutation induced by nitrosoguanidine was of non-transitional as well as transitional types. Cerda-Olmedo et al (1967) recently described the effect of nitrosoguanidine on macromolecules and their synthesis, in connection with the lethal and mutagenic action.…”

Production ofl-Leucine by a Mutant ofBrevibacterium lactofermentum2256

“…Strain 2256 is a typical bacterium producing L-glutamic acid in the presence of a limited concentration of biotin, which is required for the growth of this bacterium. 6 ) 2-Thiazolealanine resistant mutation was induced by nitrosoguanidine treatment 7 ) and the mutants were selected on a agar plate containing the minimal medium supplemented with 3000 ,ugjml of 2-thiazolealanine.…”