Mutation screening of interferon‐gamma (IFNγ) as a candidate gene for asthma

Hayden, Catherine M.; Pereira, Emma; Rye, P. J.; Lj, Palmer; Gibson, Neil; Palenque, Miguel; Hagel, Isabel; Lynch, Neil R.; Goldblatt, Jack; Lesouëf, Peter

doi:10.1046/j.1365-2222.1997.1800979.x

Cited by 21 publications

(15 citation statements)

References 22 publications

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“…Studies using a HCV replicon system showed that IFN-γ is capable of inhibiting the HCV replication [58]. Similar to other cytokines there is no polymorphism reported in the coding region; but the non-coding region possesses frequent polymorphisms which are implicated in several chronic inflammatory conditions and autoimmune diseases [59,60]. It is reported that the SNP –764G of IFN-γ which is located in the proximal promoter region was strongly associated with SVR in case of HCV infection because the G allele conferred a two to three-fold increase in the promoter activity.…”

Section: Snps Of Host Genesmentioning

confidence: 99%

Role of viral and host factors in interferon based therapy of hepatitis C virus infection

Imran

Manzoor

Ashraf³

et al. 2013

Virol J

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The current standard of care (SOC) for hepatitis C virus (HCV) infection is the combination of pegylated interferon (PEG-IFN), Ribavirin and protease inhibitor for HCV genotype 1. Nevertheless, this treatment is successful only in 70-80% of the patients. In addition, the treatment is not economical and is of immense physical burden for the subject. It has been established now, that virus-host interactions play a significant role in determining treatment outcomes. Therefore identifying biological markers that may predict the treatment response and hence treatment outcome would be useful. Both IFN and Ribavirin mainly act by modulating the immune system of the patient. Therefore, the treatment response is influenced by genetic variations of the human as well as the HCV genome. The goal of this review article is to summarize the impact of recent scientific advances in this area regarding the understanding of human and HCV genetic variations and their effect on treatment outcomes. Google scholar and PubMed have been used for literature research. Among the host factors, the most prominent associations are polymorphisms within the region of the interleukin 28B (IL28B) gene, but variations in other cytokine genes have also been linked with the treatment outcome. Among the viral factors, HCV genotypes are noteworthy. Moreover, for sustained virological responses (SVR), variations in core, p7, non-structural 2 (NS2), NS3 and NS5A genes are also important. However, all considered single nucleotide polymorphisms (SNPs) of IL28B and viral genotypes are the most important predictors for interferon based therapy of HCV infection.

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Section: Snps Of Host Genesmentioning

confidence: 99%

Role of viral and host factors in interferon based therapy of hepatitis C virus infection

Imran

Manzoor

Ashraf³

et al. 2013

Virol J

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“…435 No polymorphisms of the IFN-γ gene have been associated with asthma 436. Administration of exogenous IFN-γ prevents the airway eosinophilia and hyperresponsiveness following allergen exposure in mice 437…”

Section: Inhibitory Cytokinesmentioning

confidence: 99%

Cytokines in asthma

Chung

Barnes

1999

Thorax

564

397

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“…An association between a SNP in NOS1 and eosinophil count was also shown in German/ Swedish patients (Immervoll et al 2001). Hyden et al (1997) reported that no polymorphism in the IFNG was associated with atopic asthma, whereas an association between the GT repeat in intron 1 of IFNG and childhood asthma was suggested in the Japanese population (Nakao et al 2001). Heinzmann et al (2000a) screened polymorphisms in SCF, STAT6, TR2 (thyroid receptor 2), and LTA4H and found two polymorphisms in SCF and one in TR2 in the German population.…”

Section: Introductionmentioning

confidence: 99%

Linkage and association of childhood asthma with the chromosome 12 genes

et al. 2004

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Several studies have shown linkage of chromosome region 12q13-24 to bronchial asthma and related phenotypes in ethnically diverse populations. In the Japanese population, a genome-wide study failed to show strong evidence of linkage of this region. Chromosome 12 genes that showed association with the disease in at least one report include: the signal transducer and activator of transcription 6 gene (STAT6), the nitrogen oxide synthetase 1 gene (NOS1), the interferon c gene (IFNG), and the activation-induced cytidine deaminase gene (AICDA). To evaluate the linkage between chromosome 12 and childhood asthma in the Japanese population, we performed sib-pair linkage analysis on childhood asthma families using 18 microsatellite markers on chromosome 12. To investigate association between chromosome 12 candidate genes and asthma, distributions of alleles and genotypes of repeat polymorphisms of STAT6, NOS1, and IFNG were compared between controls and patients. Single nucleotide polymorphism of AICDA was also investigated. Chromosome region 12q24.23-q24.33 showed suggestive linkage to asthma. The NOS1 intron 2 GT repeat and STAT6 exon 1 GT repeat were associated with asthma. Neither the IFNG intron 1 CA repeat nor 465C/T of AICDA showed any association with asthma. Our results suggest that NOS1 and STAT6 are asthmasusceptibility genes and that chromosome region 12q24.23-q24.33 contains other susceptibility gene(s).

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Mutation screening of interferon‐gamma (IFNγ) as a candidate gene for asthma

Abstract: The gene for IFNgamma appears to be highly conserved as no sequence variations were detected in 265 individuals. These results suggest that mutations of the IFNgamma gene are unlikely to be a significant cause of an inherited asthma diathesis.

Cited by 21 publications

References 22 publications

Role of viral and host factors in interferon based therapy of hepatitis C virus infection

Role of viral and host factors in interferon based therapy of hepatitis C virus infection

Cytokines in asthma

Linkage and association of childhood asthma with the chromosome 12 genes

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