Mutation screening of the human period 2 gene in bipolar disorder

Shiino, Yayoi; Nakajima, Satoru; Ozeki, Yuji; Isono, Takahiro; Yamada, Naoto

doi:10.1016/s0304-3940(02)01290-9

Cited by 23 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It should be noted that additional studies have found associations between members of the molecular clock and other psychiatric disorders such as schizophrenia and alcoholism, suggesting that these genes are important in a range of psychiatric conditions (Spanagel et al, 2005;Mansour et al, 2006). However, in general, most of these studies only find modest associations, and other studies that have examined SNPs throughout the sequence of some of the central members of the circadian clock have found no associations with these genes and any psychiatric disorders (Shiino et al, 2003;Nievergelt et al, 2005;Mansour et al, 2006;Nievergelt et al, 2006). Therefore the functional importance of these variations is still uncertain, and only certain members of the circadian clock may be involved.…”

Section: Human Genetic Studiesmentioning

confidence: 99%

Circadian genes, rhythms and the biology of mood disorders

McClung

2007

Pharmacology & Therapeutics

587

386

View full text Add to dashboard Cite

For many years, researchers have suggested that abnormalities in circadian rhythms may underlie the development of mood disorders such as bipolar disorder, major depression and seasonal affective disorder. Furthermore, some of the treatments that are currently employed to treat mood disorders are thought to act by shifting or "resetting" the circadian clock, including total sleep deprivation and bright light therapy. There is also reason to suspect that many of the mood stabilizers and antidepressants used to treat these disorders may derive at least some of their therapeutic efficacy by affecting the circadian clock. Recent genetic, molecular and behavioral studies implicate individual genes that make up the clock in mood regulation. As well, important functions of these genes in brain regions and neurotransmitter systems associated with mood regulation is becoming apparent. In this review, the evidence linking circadian rhythms and mood disorders, and what is known about the underlying biology of this association, is presented.

show abstract

Section: Human Genetic Studiesmentioning

confidence: 99%

Circadian genes, rhythms and the biology of mood disorders

McClung

2007

Pharmacology & Therapeutics

587

386

View full text Add to dashboard Cite

show abstract

“…Familial forms of circadian sleep disorders (such as advanced or delayed sleep phase syndrome) manifest allelic mutations on one or other of the clock genes (Jones et al, 1999;Ebisawa et al, 2001;Iwase et al, 2002). Studies of the clock gene in major depression (Desan et al, 2000;Bailer et al, 2005) and the per2 gene in bipolar disorder (Shiino et al, 2003) have so far been negative. Circadian clock-related polymorphisms may be related to susceptibility to SAD together with evening chronotype (Johansson et al, 2003).…”

Section: Clock Genes and Depressionmentioning

confidence: 99%

Biological rhythm disturbances in mood disorders

Wirz‐Justice¹

2006

International Clinical Psychopharmacology

299

194

View full text Add to dashboard Cite

From earliest times, psychiatrists have described biological rhythm disturbances as characteristic of mood disorders. The present flourishing of circadian biology has revealed the molecular basis of 24-h rhythmicity driven by 'clock' genes, as well as the importance of zeitgebers (synchronisers). Winter depression was first modelled on regulation of animal behaviour by seasonal changes in daylength, and led to application of light as the first successful chronobiological treatment in psychiatry. Light therapy has great promise for many other disorders (e.g. sleep-wake cycle disturbances in Alzheimer's dementia, bulimia, premenstrual disorder, depression during pregnancy) and, importantly, as an adjuvant to antidepressant medication in major non-seasonal depression. The pineal hormone melatonin is also a zeitgeber for the human circadian system, in addition to possessing direct sleep-promoting effects. Chronobiology has provided efficacious non-pharmaceutical treatments for mood disorders (such as sleep deprivation or light therapy) as well as novel approaches to new drugs (e.g. agomelatine).

show abstract

“…Several circadian gene polymorphisms have been investigated, with mixed results (27–31). Haplotype‐based analyses suggest associations at Bmal I ( ARNTL ) and Period 3 ( PER3 ) (32), as well as PER3 (31), with nonsignificant associations at PER2 and Cry1 (32, 33). Another recent study that analyzed 10 circadian genes reported interactions between SNPs at BHLHB2, CSNK1E, and CLOCK (34).…”

mentioning

confidence: 99%

Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia

et al. 2009

View full text Add to dashboard Cite

Objective Published studies suggest associations between circadian gene polymorphisms and bipolar I disorder (BPI), as well as schizoaffective disorder (SZA) and schizophrenia (SZ). The results are plausible, based on prior studies of circadian abnormalities. As replications have not been attempted uniformly, we evaluated representative, common polymorphisms in all three disorders. Methods We assayed 276 publicly available ‘tag’ single nucleotide polymorphisms (SNPs) at 21 circadian genes among 523 patients with BPI, 527 patients with SZ/SZA, and 477 screened adult controls. Detected associations were evaluated in relation to two published genome-wide association studies (GWAS). Results Using gene-based tests, suggestive associations were noted between EGR3 and BPI (p = 0.017), and between NPAS2 and SZ/SZA (p = 0.034). Three SNPs were associated with both sets of disorders (NPAS2: rs13025524 and rs11123857; RORB: rs10491929; p < 0.05). None of the associations remained significant following corrections for multiple comparisons. Approximately 15% of the analyzed SNPs overlapped with an independent study that conducted GWAS for BPI; suggestive overlap between the GWAS analyses and ours was noted at ARNTL. Conclusions Several suggestive, novel associations were detected with circadian genes and BPI and SZ/SZA, but the present analyses do not support associations with common polymorphisms that confer risk with odds ratios greater than 1.5. Additional analyses using adequately powered samples are warranted to further evaluate these results.

show abstract

Mutation screening of the human period 2 gene in bipolar disorder

Cited by 23 publications

References 19 publications

Circadian genes, rhythms and the biology of mood disorders

Circadian genes, rhythms and the biology of mood disorders

Biological rhythm disturbances in mood disorders

Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia

Contact Info

Product

Resources

About