2016
DOI: 10.18632/oncotarget.11922
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Mutational burdens and evolutionary ages of thyroid follicular adenoma are comparable to those of follicular carcinoma

Abstract: Follicular thyroid adenoma (FTA) precedes follicular thyroid carcinoma (FTC) by definition with a favorable prognosis compared to FTC. However, the genetic mechanism of FTA to FTC progression remains unknown. For this, it is required to disclose FTA and FTC genomes in mutational and evolutionary perspectives. We performed whole-exome sequencing and copy number profiling of 14 FTAs and 13 FTCs, which exhibited previously-known gene mutations (NRAS, HRAS, BRAF, TSHR and EIF1AX) and copy number alterations (CNAs)… Show more

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Cited by 76 publications
(59 citation statements)
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“…For instance, CNV loss containing TP53 was observed in ATC310 and ATC312 but not in their paired PTC samples. The frequent FTC and PTC deletion 22q harboring the CHEK2 , EP300 , and NF2 genes was observed in ATC310, ATC312, ATC401, and FTC403, but it was not shared by any of their coexisting partners.…”
Section: Resultsmentioning
confidence: 99%
“…For instance, CNV loss containing TP53 was observed in ATC310 and ATC312 but not in their paired PTC samples. The frequent FTC and PTC deletion 22q harboring the CHEK2 , EP300 , and NF2 genes was observed in ATC310, ATC312, ATC401, and FTC403, but it was not shared by any of their coexisting partners.…”
Section: Resultsmentioning
confidence: 99%
“…eIF1A, the protein encoded by EIF1AX, is important in the formation of the pre-initiation complex, composed of the 40S subunit, eukaryotic translation initiation factor 1 (eIF1), eukaryotic translation initiation factor 5 (eIF5), eIF3 and the ternary complex (Bhat et al, 2015; Spilka et al, 2013), and together with eIF1, is required for mRNA scanning and binding at the initiation codon (Spilka et al, 2013). Mutations in the EIF1AX gene have been associated with tumor development and progression in thyroid cancer (Jung et al, 2016; Landa et al, 2016) uveal melanomas (Decatur et al, 2016; Field et al, 2016) and possibly ovarian tumor carcinogenesis (Hunter et al, 2015). Knowledge of its functional roles in cancer biology is still currently limited (Spilka et al, 2013) and warrant further investigations.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, next-generation sequencing (NGS) has improved our understanding of the genetics and biology of thyroid cancer, including FTC and PTC (20,21,22), and RAS point mutations are the most representative driver mutations in FTC. As the results of our study, RAS mutations have been reported to be associated with distant metastasis (11,12) and poor prognoses in FTC (9,10).…”
Section: Discussionmentioning
confidence: 99%