“…eIF1A, the protein encoded by EIF1AX, is important in the formation of the pre-initiation complex, composed of the 40S subunit, eukaryotic translation initiation factor 1 (eIF1), eukaryotic translation initiation factor 5 (eIF5), eIF3 and the ternary complex (Bhat et al, 2015; Spilka et al, 2013), and together with eIF1, is required for mRNA scanning and binding at the initiation codon (Spilka et al, 2013). Mutations in the EIF1AX gene have been associated with tumor development and progression in thyroid cancer (Jung et al, 2016; Landa et al, 2016) uveal melanomas (Decatur et al, 2016; Field et al, 2016) and possibly ovarian tumor carcinogenesis (Hunter et al, 2015). Knowledge of its functional roles in cancer biology is still currently limited (Spilka et al, 2013) and warrant further investigations.…”