Mutism and auditory agnosia due to bilateral insular damage—Role of the insula in human communication

Habib, Michel; Daquin, Géraldine; Milandre, L; Royere, Marie-Luce; Rey, Marc; Lanteri, Alessandro; Salamon, G; Khalil, Rami Bou

doi:10.1016/0028-3932(94)00108-2

Cited by 125 publications

(71 citation statements)

References 25 publications

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“…The insula spans essentially the length of primary language areas in the brain and connects to orbital, frontal opercular, lateral premotor, ventral granular, and superior temporal cortices among other areas (Mesulam and Mufson, 1985;Augustine, 1996). Regions of the insula have been implicated by studies in aspects of language-related functions (for review, see Ardila, 1999), including aphasia (Damasio and Damasio, 1980), dyslexia (Paulesu et al, 1996), affective and nonaffective prosody (Borod, 2000), and auditory agnosia (Habib et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

The Role of the Insular Cortex in Pitch Pattern Perception: The Effect of Linguistic Contexts

Wong¹,

Parsons²,

Martínez³

et al. 2004

J. Neurosci.

132

114

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Auditory pitch patterns are significant ecological features to which nervous systems have exquisitely adapted. Pitch patterns are found embedded in many contexts, enabling different information-processing goals. Do the psychological functions of pitch patterns determine the neural mechanisms supporting their perception, or do all pitch patterns, regardless of function, engage the same mechanisms? This issue is pursued in the present study by using 15 0-water positron emission tomography to study brain activations when two subject groups discriminate pitch patterns in their respective native languages, one of which is a tonal language and the other of which is not. In a tonal language, pitch patterns signal lexical meaning. Native Mandarin-speaking and English-speaking listeners discriminated pitch patterns embedded in Mandarin and English words and also passively listened to the same stimuli. When Mandarin listeners discriminated pitch embedded in Mandarin lexical tones, the left anterior insular cortex was the most active. When they discriminated pitch patterns embedded in English words, the homologous area in the right hemisphere activated as it did in English-speaking listeners discriminating pitch patterns embedded in either Mandarin or English words. These results support the view that neural responses to physical acoustic stimuli depend on the function of those stimuli and implicate anterior insular cortex in auditory processing, with the left insular cortex especially responsive to linguistic stimuli.

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Section: Discussionmentioning

confidence: 99%

The Role of the Insular Cortex in Pitch Pattern Perception: The Effect of Linguistic Contexts

Wong¹,

Parsons²,

Martínez³

et al. 2004

J. Neurosci.

132

114

View full text Add to dashboard Cite

show abstract

“…In fact, human studies not only show that the insula is activated by different forms of speech (Zatorre et al, 1994;Rumsey et al, 1997;Meyer et al, 2002;Kotz et al, 2003;Brown et al, 2004;Wong et al, 2004;Sander and Scheich, 2005), but evidence from patients also makes the case for a causal role of the insula in phonological processing. Subjects with dyslexia, for example, of- ten exhibit lower insula activation in different phonological tasks (Paulesu et al, 1996;Cornette et al, 1998), and many individuals with strokes or ischemic infarcts near the insula show deficits in acoustic or language perception (Cancelliere and Kertesz, 1990;Habib et al, 1995). Importantly, in several cases, different degrees of auditory agnosia, the inability to recognize sounds, have been well documented (Hyman and Tranel, 1989;Engelien et al, 1995;Griffiths et al, 1997).…”

Section: An Auditory Region In the Insulamentioning

confidence: 99%

“…In addition, insula lesions often manifest as deficits in sound or speech recognition (auditory agnosia) and speech production (Spreen et al, 1965;Cancelliere and Kertesz, 1990;Engelien et al, 1995;Habib et al, 1995). Despite this evidence for a central role of the insula in processing and representing vocal communication sounds, little is known about the underlying neuronal substrate.…”

Section: Introductionmentioning

confidence: 99%

An Auditory Region in the Primate Insular Cortex Responding Preferentially to Vocal Communication Sounds

Remedios¹,

Logothetis²,

Kayser³

2009

J. Neurosci.

131

100

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Human imaging studies implicate the insular cortex in processing complex sounds and vocal communication signals such as speech. In addition, lesions of the insula often manifest as deficits in sound or speech recognition (auditory agnosia) and speech production. While models of acoustic perception assign an important role to the insula, little is known about the underlying neuronal substrate. Studying a vocal primate, we identified a predominantly auditory region in the caudal insula and therein discovered a neural representation of conspecific communication sounds. When probed with natural sounds, insula neurons exhibited higher response selectivity than neurons in auditory cortex, and in contrast to these, responded preferentially to conspecific vocalizations. Importantly, insula neurons not only preferred conspecific vocalizations over a wide range of environmental sounds and other animal vocalizations, but also over acoustically manipulated versions of these, demonstrating that this preference for vocalizations arises both from spectral and temporal features of the sounds. In addition, individual insula neurons responded highly selectively to only a few vocalizations and allowed the decoding of sound identity from single-trial responses. These findings characterize the caudal insula as a selectively responding auditory region, possibly part of a processing stream involved in the representation of communication sounds. Importantly, our results provide a neural counterpart for the human imaging and lesion findings and uncover a basis for a supposed role of the insula in processing vocal communication sounds such as speech.

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“…A search of the literature yielded 16 cases of auditory agnosia that met these criteria. Of these, 4 were nonverbal auditory agnosics (Albert et al, 1972;De La Sayette et al, 1994;Habib et al, 1995;Taniwaki et al, 2000), 8 were verbal auditory agnosics (Buchman et al, 1986, cases 1 and 2;Coslett et al, 1984;Klein and Harper, 1956;Mendez and Rosenberg, 1991;Otsuki et al, 1998;E. Wang et al, 2000;Papathanasiou, 1998), and 4 were complete auditory agnosics (Garde and Cowey, 2000;Kaga et al, 2000;Michel et al, 1980;Rosati et al, 1982).…”

Section: Neuropsychological Datamentioning

confidence: 99%

The Neuropsychology of Autobiographical Memory

Greenberg

Rubin

2003

Cortex

254

151

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This special issue of Cortex focuses on the relative contribution of different neural networks to memory and the interaction of 'core' memory processes with other cognitive processes. In this article, we examine both. Specifically, we identify cognitive processes other than encoding and retrieval that are thought to be involved in memory; we then examine the consequences of damage to brain regions that support these processes. This approach forces a consideration of the roles of brain regions outside of the frontal, medialtemporal, and diencephalic regions that form a central part of neurobiological theories of memory. Certain kinds of damage to visual cortex or lateral temporal cortex produced impairments of visual imagery or semantic memory; these patterns of impairment are associated with a unique pattern of amnesia that was distinctly different from the pattern associated with medial-temporal trauma. On the other hand, damage to language regions, auditory cortex, or parietal cortex produced impairments of language, auditory imagery, or spatial imagery; however, these impairments were not associated with amnesia. Therefore, a full model of autobiographical memory must consider cognitive processes that are not generally considered 'core processes,' as well as the brain regions upon which these processes depend.

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Mutism and auditory agnosia due to bilateral insular damage—Role of the insula in human communication

Cited by 125 publications

References 25 publications

The Role of the Insular Cortex in Pitch Pattern Perception: The Effect of Linguistic Contexts

The Role of the Insular Cortex in Pitch Pattern Perception: The Effect of Linguistic Contexts

An Auditory Region in the Primate Insular Cortex Responding Preferentially to Vocal Communication Sounds

The Neuropsychology of Autobiographical Memory

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