The mixed spin-(1/2,5/2) Ising-XXZ on quasi-one-dimensional lattices can be used to study the properties of some materials (such as heterotrimetallic Fe-Mn-Cu coordination polymer), and the study to this model is beneficial for practical application of such materials in the field of quantum information. The quantum coherence and mutual information are calculated by transfer matrix method, and the effects of Ising interaction, temperature and magnetic field on them are discussed. The results show that the quantum coherence decreases gradually with increasing Ising interaction at extremely low temperatures, while there are a minimum of mutual information in isotropic systems and four minima in anisotropic Δ=4 systems. Furthermore, quantum coherence and mutual information jump abruptly at quantum phase transition points where the first derivatives of them exhibit singular behaviors. The quantum coherence and mutual information at finite temperatures are also studied. As the temperature increases, they decrease monotonously at weak magnetic field and increase firstly and then decrease at higher one, which caused by the competition between thermal fluctuation and magnetic field. Compared with quantum mutual information, quantum coherence exists over a wider range of magnetic field and temperature, which can be easily manipulated experimentally.