MXene-based nanomaterials with enzyme-like properties for biomedical applications

Yang, Rong; Wen, Shiqi; Cai, Shuangfei; Zhang, Wei; Wu, Ting; Xiong, Youlin

doi:10.1039/d3nh00213f

Cited by 5 publications

(3 citation statements)

References 101 publications

(229 reference statements)

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“…As the most typical MXene, Ti 3 C 2 has been studied to combine with many semiconductors to help it play a catalytic role in sonodynamic therapy (SDT) and chemodynamic therapy (CDT) [ 38 , 42 – 44 ]. Although MXene is a good optional catalytic supporter, it may have limitations in mimicking the activity of peroxidase, which may affect its efficacy in therapeutic and assay applications [ 45 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactive VS4-based sonosensitizer for robust chemodynamic, sonodynamic and osteogenic therapy of infected bone defects

He,

Liu,

Lei

et al. 2024

J Nanobiotechnol

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Background Most bone defects caused by bone disease or trauma are accompanied by infection, and there is a high risk of infection spread and defect expansion. Traditional clinical treatment plans often fail due to issues like antibiotic resistance and non-union of bones. Therefore, the treatment of infected bone defects requires a strategy that simultaneously achieves high antibacterial efficiency and promotes bone regeneration. Results In this study, an ultrasound responsive vanadium tetrasulfide-loaded MXene (VSM) Schottky junction is constructed for rapid methicillin-resistant staphylococcus aureus (MRSA) clearance and bone regeneration. Due to the peroxidase (POD)-like activity of VS4 and the abundant Schottky junctions, VSM has high electron–hole separation efficiency and a decreased band gap, exhibiting a strong chemodynamic and sonodynamic antibacterial efficiency of 94.03%. Under the stimulation of medical dose ultrasound, the steady release of vanadium element promotes the osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs). The in vivo application of VSM in infected tibial plateau bone defects of rats also has a great therapeutic effect, eliminating MRSA infection, then inhibiting inflammation and improving bone regeneration. Conclusion The present work successfully develops an ultrasound responsive VS4-based versatile sonosensitizer for robust effective antibacterial and osteogenic therapy of infected bone defects.

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Section: Introductionmentioning

confidence: 99%

Bioactive VS4-based sonosensitizer for robust chemodynamic, sonodynamic and osteogenic therapy of infected bone defects

He,

Liu,

Lei

et al. 2024

J Nanobiotechnol

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“…Nanomaterials can interact with microorganisms without relying on antibiotics through multivalent interaction (multivalent interaction) to inhibit cellular functions ( Fu et al, 2019 ; Pashazadeh-Panahi and Hasanzadeh, 2019 ; Yu et al, 2020 ). Two-dimensional (2D) materials such as graphene, black phosphorus (BP), transition metal sulfide (TMDC), hexagonal boron nitride (hBN), and graphitic carbon nitride have been successfully used as novel antimicrobial agents or biological applications by their excellent electrical conductivity, mechanical properties, and remarkable properties in fighting bacterial infections ( Novoselov et al, 2004 ; Wang et al, 2020a ; Tan et al, 2020 ; Yang et al, 2023 ). However, these materials also have certain party limitations, such as graphene lack of bandgap and visible region light absorption ( Wang et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

MXene: A wonderful nanomaterial in antibacterial

Ye,

Zhang,

Lai

et al. 2024

Front. Bioeng. Biotechnol.

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Increasing bacterial infections and growing resistance to available drugs pose a serious threat to human health and the environment. Although antibiotics are crucial in fighting bacterial infections, their excessive use not only weakens our immune system but also contributes to bacterial resistance. These negative effects have caused doctors to be troubled by the clinical application of antibiotics. Facing this challenge, it is urgent to explore a new antibacterial strategy. MXene has been extensively reported in tumor therapy and biosensors due to its wonderful performance. Due to its large specific surface area, remarkable chemical stability, hydrophilicity, wide interlayer spacing, and excellent adsorption and reduction ability, it has shown wonderful potential for biopharmaceutical applications. However, there are few antimicrobial evaluations on MXene. The current antimicrobial mechanisms of MXene mainly include physical damage, induced oxidative stress, and photothermal and photodynamic therapy. In this paper, we reviewed MXene-based antimicrobial composites and discussed the application of MXene in bacterial infections to guide further research in the antimicrobial field.

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“…The remarkable electrical conductivity and numerous functional groups of MXenes, which are highly promising for use in the fields of tissue engineering and regenerative medicine, merit attention in this regard. 24–27…”

Section: Introductionmentioning

confidence: 99%

MXene and Xene: promising frontier beyond graphene in tissue engineering and regenerative medicine

Kang,

Jang,

et al. 2024

Nanoscale Horiz.

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MXene-based nanomaterials with enzyme-like properties for biomedical applications

Abstract: Recently, great progress has been made in nanozyme research due to the rapid development of nanomaterials and nanotechnology. MXene-based nanomaterials have gained considerable attention due to their unique physicochemical properties....

Cited by 5 publications

References 101 publications

Bioactive VS4-based sonosensitizer for robust chemodynamic, sonodynamic and osteogenic therapy of infected bone defects

Bioactive VS4-based sonosensitizer for robust chemodynamic, sonodynamic and osteogenic therapy of infected bone defects

MXene: A wonderful nanomaterial in antibacterial

MXene and Xene: promising frontier beyond graphene in tissue engineering and regenerative medicine

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