Independent Component Analysis (ICA) is a powerful technique for blind source separation. It has been successfully applied to signal processing problems, such as feature extraction and noise reduction, in many different areas including medical signal processing and telecommunication. In this work, we propose a framework to apply ICA to denoise side-channel measurements and hence to reduce the complexity of key recovery attacks. Based on several case studies, we afterwards demonstrate the overwhelming advantages of ICA with respect to the commonly used preprocessing techniques such as the singular spectrum analysis. Mainly, we target a software masked implementation of an AES and a hardware unprotected one. Our results show a significant Signalto-Noise Ratio (SNR) gain which translates into a gain in the number of traces needed for a successful side-channel attack. This states the ICA as an important new tool for the security assessment of cryptographic implementations.