Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Carruthers, Bruce M.; Jain, Anil K.; Meirleir, Kenny L. De; Peterson, Daniel L.; Klimas, Nancy G.; Lerner, A. Martin; Bested, Alison; Flor-Henry, Pierre; Joshi, Pradip; Powles, A. C. Peter; Sherkey, Jeffrey A.; Sande, Marjorie I. van de

doi:10.1300/j092v11n01_02

Cited by 877 publications

(566 citation statements)

References 77 publications

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“…All subjects were recruited for the study by telephone contact within a 1-week period, starting with the most impaired, until 105 patients were successfully enrolled. At enrollment, subjects were screened to determine if they met the Canadian consensus criteria (1), and all but 5 qualified for both case definitions. Subjects were administered the Rand SF-36 (26).…”

Section: Methodsmentioning

confidence: 99%

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Absence of XMRV Retrovirus and Other Murine Leukemia Virus-Related Viruses in Patients with Chronic Fatigue Syndrome

Shin

Bateman²,

Salais

et al. 2011

J Virol

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Chronic fatigue syndrome (CFS) is a multisystem disorder characterized by prolonged and severe fatigue that is not relieved by rest. Attempts to treat CFS have been largely ineffective primarily because the etiology of the disorder is unknown. Recently, CFS has been associated with xenotropic murine leukemia virus-related virus (XMRV) as well as other murine leukemia virus (MLV)-related viruses, though not all studies have found these associations. We collected blood samples from 100 CFS patients and 200 self-reported healthy volunteers from the same geographical area. We analyzed these in a blind manner using molecular, serological, and viral replication assays. We also analyzed samples from patients in the original study that reported XMRV in CFS patients. We did not find XMRV or related MLVs either as viral sequences or infectious viruses, nor did we find antibodies to these viruses in any of the patient samples, including those from the original study. We show that at least some of the discrepancy with previous studies is due to the presence of trace amounts of mouse DNA in the Taq polymerase enzymes used in these previous studies. Our findings do not support an association between CFS and MLV-related viruses, including XMRV, and the off-label use of antiretrovirals for the treatment of CFS does not seem justified at present.

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Section: Methodsmentioning

confidence: 99%

“…We enrolled 105 CFS patients, including 100 who fulfilled both the 1994 case definition of the CDC (4) as well as the criteria defined by the Canadian consensus document on myalgic encephalomyelitis (ME)/CFS (1). Patients and 200 healthy volunteers were all from the greater Salt Lake City area.…”

mentioning

confidence: 99%

Absence of XMRV Retrovirus and Other Murine Leukemia Virus-Related Viruses in Patients with Chronic Fatigue Syndrome

Shin

Bateman²,

Salais

et al. 2011

J Virol

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“…Secondly, we recognise the inherent challenges of diagnostic criteria for CFS/ME. The criteria is deemed unsatisfactory Running head: Psychological flexibility in CFS/ME 15 by some as it is achieved through exclusion of medical causes of fatigue and the lack of discrimination of other similar conditions including mental health disorders [41]. Variability in duration of symptoms in our sample adds further complexity, suggesting the need for greater homogeneity of sample characteristics and further exploration of symptom duration in understanding the development of PF processes.…”

Section: Limitationsmentioning

confidence: 99%

Enhanced psychological flexibility and improved quality of life in chronic fatigue syndrome/myalgic encephalomyelitis

Densham

Williams

Johnson

et al. 2016

Journal of Psychosomatic Research

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Objective: Psychological Flexibility (PF) is a relatively new concept in physical health. It can be defined as an overarching process of being able to accept the presence of wanted/unwanted experiences, choosing whether to change or persist in behaviour in response to those experiences. Associations between processes of PF and quality of life (QoL) have been found in long-term health conditions such as chronic pain, PF has not yet been applied to Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). Methods:Changes in PF, fatigue severity and QoL were examined in one hundred and sixtyfive patients with CFS/ME engaged in a six-week outpatient interdisciplinary group treatment programme. Participants were assessed using a series of self-report measures at the start of the start (T1) and end of a six-week programme (T2) and at six months follow up (T3).Results: Significant changes in PF and QoL were observed from pre-treatment (T1) to post treatment follow-up (T2 and T3); changes in fatigue severity were observed from T1 to T3 only. Controlling for fatigue severity, changes in the PF dimension of activity/occupational engagement were associated with improvement in QoL at six month follow up (T3) but not at six weeks post programme (T2). Conclusion:Findings indicate an interdisciplinary group treatment approach for people with CFS/ME may be associated with improved QoL, processes of PF and fatigue severity, supporting a link between PF and long term health conditions. Results highlight links Running head: Psychological flexibility in CFS/ME 3 between PF and patient QoL in CFS/ME and the value of interdisciplinary treatment approaches in this patient population. Keywords

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“…People with CFS were eligible if they had been diagnosed with CFS and met both the Centers for Disease Control and Prevention research guidelines for CFS 15 and the Canadian clinical guidelines for CFS. 16 Healthy control (HC) participants were a convenience sample of volunteers.…”

Section: Participantsmentioning

confidence: 99%

Short-Term Effect of Aerobic Exercise on Symptoms in Multiple Sclerosis and Chronic Fatigue Syndrome

Learmonth¹,

Paul²,

McFadyen³

et al. 2014

International Journal of MS Care

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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Cited by 877 publications

References 77 publications

Absence of XMRV Retrovirus and Other Murine Leukemia Virus-Related Viruses in Patients with Chronic Fatigue Syndrome

Absence of XMRV Retrovirus and Other Murine Leukemia Virus-Related Viruses in Patients with Chronic Fatigue Syndrome

Enhanced psychological flexibility and improved quality of life in chronic fatigue syndrome/myalgic encephalomyelitis

Short-Term Effect of Aerobic Exercise on Symptoms in Multiple Sclerosis and Chronic Fatigue Syndrome

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