Myasthenia Gravis and Diabetes Mellitus: -A 35-year Retrospective Study-

Wakata, Nobuo; Nemoto, Hiroshi; Konno, S.; Nakazora, Hiroshi; Nomoto, Nobuatsu; Sugimoto, Hideki; Kurihara, Toshio

doi:10.2169/internalmedicine.46.6237

Cited by 9 publications

(12 citation statements)

References 6 publications

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“…The gender prevalence of DM was higher in men in the general population (17) and patients with MG (4) and RA (12). Our MG cohort study confirmed these results, which is atypical compared with the higher MG prevalence in female patients (4,16).…”

Section: Discussionsupporting

confidence: 77%

“…This nationwide population-based cohort study demonstrated that MG was associated with risk of DM in 1520 Taiwanese patients with MG. The prevalence of DM in MG patients has varied widely from 2% to 16.7% in previous hospital-based reports (4,5,11). This variability might be related to the selection criteria of DM and the length of observation.…”

Section: Discussionmentioning

confidence: 98%

“…This variability might be related to the selection criteria of DM and the length of observation. Japanese researchers reported the prevalence of type II DM in MG as 3.4% (11 of 325 patients) (4). Canadian researchers reported the prevalence of type I DM and type II DM as 9.3% and 7.4%, respectively, in 108 patients with MG (5).…”

Section: Discussionmentioning

confidence: 99%

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Risk of diabetes mellitus among patients with myasthenia gravis

et al. 2015

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 98%

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Risk of diabetes mellitus among patients with myasthenia gravis

et al. 2015

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“…It is more frequent in men than women (29 vs 16 %). Patients with MG and DM may have positive more organ-specific antibodies (with DM type 1), or onset of DM during corticosteroid therapy (DM type 2) [ 38 ]. Doses of prednisolone higher than 30 mg/day increase the level of glycaemia in patients who already have DM, and can cause glucose intolerance or diabetes in previously normoglycaemic subjects [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Myasthenia Gravis and Associated Diseases

Tanovska¹,

Novotni²,

Sazdova-Burneska³

et al. 2018

Open Access Maced J Med Sci

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BACKGROUND:Myasthenia gravis (MG) is an autoimmune disease caused by the action of specific antibodies to the postsynaptic membrane of the neuromuscular junction, leading to impaired neuromuscular transmission. Patients with MG have an increased incidence of other autoimmune diseases.AIM:to determine the presence of other associated diseases in patients with MG.METHOD:A group of 127 patients with MG followed in 10 years period, in which the presence of other associated diseases has been analysed.RESULTS:The sex ratio is in favour of the female sex, the average age of the initial manifestation of the disease is less than 50 years, 65.4% of the patients with MG have another disease. 15.0% patients have associated another autoimmune disease. Thyroid disease is the most common associated with MG, rarely rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other autoimmune diseases. Other diseases include hypertension, heart disease, diabetes, respiratory diseases, dyslipidemia. 10.2% of the patients are diagnosed with extrathymic tumours of various origins.CONCLUSION:Associated diseases are common in patients with MG, drawing attention to the possible common basis for their coexistence, as well as their impact on the intensity and treatment of the disease.

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“…Among refractory MG patients, 22 patients (28.94%) have diabetes mellitus. Detailed prevalence reports of association of diabetes mellitus with MG are lacking, but it is estimated to be 2–3% [ 32 ], [ 33 ]. According to a Taiwanese study, MG cohort had a 1.26-fold increased risk of developing DM compared with the comparison cohort [ 34 ].…”

Section: Discussionmentioning

confidence: 99%