Myasthenia gravis in current status: epidemiology, types, etiology, pathophysiology, symptoms, diagnostic tests, prevention, treatment, and complications – correspondence

Rahman, Md. Mominur; Islam, Md. Rezaul; Dhar, Puja Sutro

doi:10.1097/js9.0000000000000164

Cited by 6 publications

(4 citation statements)

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“…Many patients have probably mistaken it for a severe disease exacerbation, as epidemiological data do not indicate that myasthenic crisis is so common among MG patients (29). Crisis with a transient need of intensive care and respiratory support usually occurs in 15-20% of all MG patients and can be precipitated by infection, a stressful situation, a surgical procedure, or as a reaction to medication (8,30). Modifiable risk factors for disease exacerbation should be identified, discussed with the patient, and treated.…”

Section: Discussionmentioning

confidence: 99%

“…Over half of the study patients had their thymus resected. Anxiety about a potential thymus tumor can affect patients' wellbeing, as the incidence of thymoma is 10-15% of all MG patients (8,32,33). Surgical removal of the tumor and the good prognosis may reduce the prevalence of anxiety and depression among MG patients with thymoma (34,35).…”

Section: Discussionmentioning

confidence: 99%

“…It is the most common neuromuscular transmission disorder, primarily affecting adults (5)(6)(7). Its prevalence has increased in recent decades as detection and survival rates have improved (8,9). Although the exact cause of MG is unknown, the thymus appears to play a role (10,11).…”

Section: Introductionmentioning

confidence: 99%

“…Viral and bacterial infections have been suggested to initiate the immune response (12,13). Additionally, thyroid disease is present in 3-8% of MG patients, and tumors are found in the thymus of 10-15% of patients (8,14). A typical symptom is general muscle weakness affecting the bulbar muscles and those responsible for limb and eye movements (15-17).…”

Section: Introductionmentioning

confidence: 99%

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Diagnosis and therapy of myasthenia gravis—the patients’ perspective: a cross-sectional study

et al. 2023

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The survey aimed to explore patients’ perspectives with myasthenia gravis (MG) toward the diagnosis made and the therapy used to treat MG. The survey was conducted with a quantitative method, using the CAWI technique. A total of 321 people participated in the survey. More than half of the respondents (56.4%) had suffered from MG for less than 10 years. In three out of 10 cases (30.9%), the diagnosis of MG lasted 3 years or longer. The diagnostic delay was significantly longer in female respondents than in the males (p = 0.029). Cholinergic drugs were used in 92.9% of cases initially, and as maintenance therapy in 84.3% of cases. Corticosteroids were used in initiating therapy (45.8%) and as maintenance therapy (46.4%). One in four respondents (25.5%) reported experiencing very strong and strong side effects after using steroids. The side effects from steroid therapy very strong or strong affected overall physical health in 55.9% of respondents, very strong or strong affected self-acceptance in 52%, to a very large or large extent on mental health in 47.1%, and to a very strong or strong extent influenced the performance of daily activities in 28.2%. More than half of the respondents (57.0%) had had a thymectomy. Seven out of 10 respondents (72.0%) declared that the therapy they were on at the time of the survey allowed them (to varying degrees) to control their course of MG. Low therapy acceptance and less well controlled MG was associated with a preference for non-tablet therapies (p = 0.045). Regular follow-up and cooperation with the specialist health care system should improve MG symptoms, activities of daily living, and quality of life.

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Section: Discussionmentioning

confidence: 99%